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Q4FL49

- FTHS_PELUB

UniProt

Q4FL49 - FTHS_PELUB

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 778ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPEL335992:GH3Z-1300-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SAR11_1285
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000002528: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Formate--tetrahydrofolate ligasePRO_0000199366Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335992.SAR11_1285.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FL49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEVKSDIQI AREAKMQPIN DILAKINVPD ESSAFSPMGR HIAKINLEYL
60 70 80 90 100
DTLKDKPNGK LVLVTAITPT PAGEGKTTTS VGLNDGLNKI GKKSIVCLRE
110 120 130 140 150
PSLGPSFGMK GGAAGGGYAQ VVPMEQINLH FTGDFHAITS AHNLLSALID
160 170 180 190 200
NHIYWGNKLD IDVRRIVWKR VMDMNDRSLR SININLGGVA NGFPREDGFD
210 220 230 240 250
ITVASEIMAI FCLSNDLEDL EKRIGNITIA YTRDKKPVYA KDLKAQGPMT
260 270 280 290 300
VLLKDAIRPN VTQTLENNPA IIHGGPFANI AHGCNSVIAT KTGLKLADYV
310 320 330 340 350
VTEAGFGADL GAEKFLDIKC RKSDLKPSCV VIVATIRALK MHGGVAKDDL
360 370 380 390 400
KTENVEALKK GLVNLQRHVE NVKKFGLPVA VAVNHFIKDT ENEVKALIEF
410 420 430 440 450
CDTIGVKASL CTHWANGGEG TKELASHVAE LCEKNEDKFK FLYESKTPLF
460 470 480 490 500
KKIETIAKEI YRADEVIADT KIRDQLKSFE DAGYGDFPIC IAKTQYSFST
510 520 530 540 550
DPSLKGAPTG HSLPIREIKL SSGAEFIVVI CGAVMTMPGL PRVPAADSIK
560
LNKDGEIEGL F
Length:561
Mass (Da):61,012
Last modified:August 30, 2005 - v1
Checksum:i001C108301484770
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ22089.1.
RefSeqiWP_011282279.1. NC_007205.1.
YP_266693.1. NC_007205.1.

Genome annotation databases

EnsemblBacteriaiAAZ22089; AAZ22089; SAR11_1285.
GeneIDi3517322.
KEGGipub:SAR11_1285.
PATRICi31992073. VBICanPel5618_1275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ22089.1 .
RefSeqi WP_011282279.1. NC_007205.1.
YP_266693.1. NC_007205.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335992.SAR11_1285.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ22089 ; AAZ22089 ; SAR11_1285 .
GeneIDi 3517322.
KEGGi pub:SAR11_1285.
PATRICi 31992073. VBICanPel5618_1275.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CPEL335992:GH3Z-1300-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC1062.

Entry informationi

Entry nameiFTHS_PELUB
AccessioniPrimary (citable) accession number: Q4FL49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3