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Q4FL49

- FTHS_PELUB

UniProt

Q4FL49 - FTHS_PELUB

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi70 – 778ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPEL335992:GH3Z-1300-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:SAR11_1285
    OrganismiPelagibacter ubique (strain HTCC1062)
    Taxonomic identifieri335992 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
    ProteomesiUP000002528: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561Formate--tetrahydrofolate ligasePRO_0000199366Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335992.SAR11_1285.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FL49-1 [UniParc]FASTAAdd to Basket

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    MSEVKSDIQI AREAKMQPIN DILAKINVPD ESSAFSPMGR HIAKINLEYL    50
    DTLKDKPNGK LVLVTAITPT PAGEGKTTTS VGLNDGLNKI GKKSIVCLRE 100
    PSLGPSFGMK GGAAGGGYAQ VVPMEQINLH FTGDFHAITS AHNLLSALID 150
    NHIYWGNKLD IDVRRIVWKR VMDMNDRSLR SININLGGVA NGFPREDGFD 200
    ITVASEIMAI FCLSNDLEDL EKRIGNITIA YTRDKKPVYA KDLKAQGPMT 250
    VLLKDAIRPN VTQTLENNPA IIHGGPFANI AHGCNSVIAT KTGLKLADYV 300
    VTEAGFGADL GAEKFLDIKC RKSDLKPSCV VIVATIRALK MHGGVAKDDL 350
    KTENVEALKK GLVNLQRHVE NVKKFGLPVA VAVNHFIKDT ENEVKALIEF 400
    CDTIGVKASL CTHWANGGEG TKELASHVAE LCEKNEDKFK FLYESKTPLF 450
    KKIETIAKEI YRADEVIADT KIRDQLKSFE DAGYGDFPIC IAKTQYSFST 500
    DPSLKGAPTG HSLPIREIKL SSGAEFIVVI CGAVMTMPGL PRVPAADSIK 550
    LNKDGEIEGL F 561
    Length:561
    Mass (Da):61,012
    Last modified:August 30, 2005 - v1
    Checksum:i001C108301484770
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ22089.1.
    RefSeqiYP_266693.1. NC_007205.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ22089; AAZ22089; SAR11_1285.
    GeneIDi3517322.
    KEGGipub:SAR11_1285.
    PATRICi31992073. VBICanPel5618_1275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000084 Genomic DNA. Translation: AAZ22089.1 .
    RefSeqi YP_266693.1. NC_007205.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335992.SAR11_1285.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ22089 ; AAZ22089 ; SAR11_1285 .
    GeneIDi 3517322.
    KEGGi pub:SAR11_1285.
    PATRICi 31992073. VBICanPel5618_1275.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CPEL335992:GH3Z-1300-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC1062.

    Entry informationi

    Entry nameiFTHS_PELUB
    AccessioniPrimary (citable) accession number: Q4FL49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3