Q4FL49 (FTHS_PELUB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	SAR11_1285

Organism

Pelagibacter ubique (strain HTCC1062) [Complete proteome] [HAMAP]

Taxonomic identifier

335992 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › unclassified Alphaproteobacteria › SAR11 cluster › Candidatus Pelagibacter › Pelagibacter ubique

Protein attributes

Sequence length	561 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate interconversion Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 561	561	Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543		PRO_0000199366
Regions
	Nucleotide binding	70 – 77	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4FL49 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 001C108301484770	FASTA	561	61,012
	10 20 30 40 50 60 MSEVKSDIQI AREAKMQPIN DILAKINVPD ESSAFSPMGR HIAKINLEYL DTLKDKPNGK 70 80 90 100 110 120 LVLVTAITPT PAGEGKTTTS VGLNDGLNKI GKKSIVCLRE PSLGPSFGMK GGAAGGGYAQ 130 140 150 160 170 180 VVPMEQINLH FTGDFHAITS AHNLLSALID NHIYWGNKLD IDVRRIVWKR VMDMNDRSLR 190 200 210 220 230 240 SININLGGVA NGFPREDGFD ITVASEIMAI FCLSNDLEDL EKRIGNITIA YTRDKKPVYA 250 260 270 280 290 300 KDLKAQGPMT VLLKDAIRPN VTQTLENNPA IIHGGPFANI AHGCNSVIAT KTGLKLADYV 310 320 330 340 350 360 VTEAGFGADL GAEKFLDIKC RKSDLKPSCV VIVATIRALK MHGGVAKDDL KTENVEALKK 370 380 390 400 410 420 GLVNLQRHVE NVKKFGLPVA VAVNHFIKDT ENEVKALIEF CDTIGVKASL CTHWANGGEG 430 440 450 460 470 480 TKELASHVAE LCEKNEDKFK FLYESKTPLF KKIETIAKEI YRADEVIADT KIRDQLKSFE 490 500 510 520 530 540 DAGYGDFPIC IAKTQYSFST DPSLKGAPTG HSLPIREIKL SSGAEFIVVI CGAVMTMPGL 550 560 PRVPAADSIK LNKDGEIEGL F

References

[1]

"Genome streamlining in a cosmopolitan oceanic bacterium." Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J. Science 309:1242-1245(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTCC1062.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000084 Genomic DNA. Translation: AAZ22089.1.
RefSeq	YP_266693.1. NC_007205.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	335992.SAR11_1285.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ22089; AAZ22089; SAR11_1285.
GeneID	3517322.
KEGG	pub:SAR11_1285.
PATRIC	31992073. VBICanPel5618_1275.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HOG000040280.
KO	K01938.
OMA	EIMAVLC.
Enzyme and pathway databases
BioCyc	CPEL335992:GH3Z-1265-MONOMER.
UniPathway	UPA00193.
Family and domain databases
HAMAP	MF_01543. FTHFS.
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_PELUB

Accession

Primary (citable) accession number: Q4FL49

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program