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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 778ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPEL335992:GH3Z-1300-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SAR11_1285
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000002528 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Formate--tetrahydrofolate ligasePRO_0000199366Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335992.SAR11_1285.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FL49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVKSDIQI AREAKMQPIN DILAKINVPD ESSAFSPMGR HIAKINLEYL
60 70 80 90 100
DTLKDKPNGK LVLVTAITPT PAGEGKTTTS VGLNDGLNKI GKKSIVCLRE
110 120 130 140 150
PSLGPSFGMK GGAAGGGYAQ VVPMEQINLH FTGDFHAITS AHNLLSALID
160 170 180 190 200
NHIYWGNKLD IDVRRIVWKR VMDMNDRSLR SININLGGVA NGFPREDGFD
210 220 230 240 250
ITVASEIMAI FCLSNDLEDL EKRIGNITIA YTRDKKPVYA KDLKAQGPMT
260 270 280 290 300
VLLKDAIRPN VTQTLENNPA IIHGGPFANI AHGCNSVIAT KTGLKLADYV
310 320 330 340 350
VTEAGFGADL GAEKFLDIKC RKSDLKPSCV VIVATIRALK MHGGVAKDDL
360 370 380 390 400
KTENVEALKK GLVNLQRHVE NVKKFGLPVA VAVNHFIKDT ENEVKALIEF
410 420 430 440 450
CDTIGVKASL CTHWANGGEG TKELASHVAE LCEKNEDKFK FLYESKTPLF
460 470 480 490 500
KKIETIAKEI YRADEVIADT KIRDQLKSFE DAGYGDFPIC IAKTQYSFST
510 520 530 540 550
DPSLKGAPTG HSLPIREIKL SSGAEFIVVI CGAVMTMPGL PRVPAADSIK
560
LNKDGEIEGL F
Length:561
Mass (Da):61,012
Last modified:August 30, 2005 - v1
Checksum:i001C108301484770
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000084 Genomic DNA. Translation: AAZ22089.1.
RefSeqiWP_011282279.1. NC_007205.1.
YP_266693.1. NC_007205.1.

Genome annotation databases

EnsemblBacteriaiAAZ22089; AAZ22089; SAR11_1285.
KEGGipub:SAR11_1285.
PATRICi31992073. VBICanPel5618_1275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000084 Genomic DNA. Translation: AAZ22089.1.
RefSeqiWP_011282279.1. NC_007205.1.
YP_266693.1. NC_007205.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi335992.SAR11_1285.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ22089; AAZ22089; SAR11_1285.
KEGGipub:SAR11_1285.
PATRICi31992073. VBICanPel5618_1275.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciCPEL335992:GH3Z-1300-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC1062.

Entry informationi

Entry nameiFTHS_PELUB
AccessioniPrimary (citable) accession number: Q4FL49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 30, 2005
Last modified: April 29, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.