SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4FL49

- FTHS_PELUB

UniProt

Q4FL49 - FTHS_PELUB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Formate--tetrahydrofolate ligase
Gene
fhs, SAR11_1285
Organism
Pelagibacter ubique (strain HTCC1062)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 778ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPEL335992:GH3Z-1300-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:SAR11_1285
OrganismiPelagibacter ubique (strain HTCC1062)
Taxonomic identifieri335992 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 clusterCandidatus Pelagibacter
ProteomesiUP000002528: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199366Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335992.SAR11_1285.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FL49-1 [UniParc]FASTAAdd to Basket

« Hide

MSEVKSDIQI AREAKMQPIN DILAKINVPD ESSAFSPMGR HIAKINLEYL    50
DTLKDKPNGK LVLVTAITPT PAGEGKTTTS VGLNDGLNKI GKKSIVCLRE 100
PSLGPSFGMK GGAAGGGYAQ VVPMEQINLH FTGDFHAITS AHNLLSALID 150
NHIYWGNKLD IDVRRIVWKR VMDMNDRSLR SININLGGVA NGFPREDGFD 200
ITVASEIMAI FCLSNDLEDL EKRIGNITIA YTRDKKPVYA KDLKAQGPMT 250
VLLKDAIRPN VTQTLENNPA IIHGGPFANI AHGCNSVIAT KTGLKLADYV 300
VTEAGFGADL GAEKFLDIKC RKSDLKPSCV VIVATIRALK MHGGVAKDDL 350
KTENVEALKK GLVNLQRHVE NVKKFGLPVA VAVNHFIKDT ENEVKALIEF 400
CDTIGVKASL CTHWANGGEG TKELASHVAE LCEKNEDKFK FLYESKTPLF 450
KKIETIAKEI YRADEVIADT KIRDQLKSFE DAGYGDFPIC IAKTQYSFST 500
DPSLKGAPTG HSLPIREIKL SSGAEFIVVI CGAVMTMPGL PRVPAADSIK 550
LNKDGEIEGL F 561
Length:561
Mass (Da):61,012
Last modified:August 30, 2005 - v1
Checksum:i001C108301484770
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ22089.1.
RefSeqiYP_266693.1. NC_007205.1.

Genome annotation databases

EnsemblBacteriaiAAZ22089; AAZ22089; SAR11_1285.
GeneIDi3517322.
KEGGipub:SAR11_1285.
PATRICi31992073. VBICanPel5618_1275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000084 Genomic DNA. Translation: AAZ22089.1 .
RefSeqi YP_266693.1. NC_007205.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 335992.SAR11_1285.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ22089 ; AAZ22089 ; SAR11_1285 .
GeneIDi 3517322.
KEGGi pub:SAR11_1285.
PATRICi 31992073. VBICanPel5618_1275.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CPEL335992:GH3Z-1300-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC1062.

Entry informationi

Entry nameiFTHS_PELUB
AccessioniPrimary (citable) accession number: Q4FL49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi