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Unreviewed, UniProtKB/TrEMBL Q4FK45 (Q4FK45_MOUSE)

Last modified February 9, 2010. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesSubmitted name:
    Ccnd2 protein EMBL CAJ18415.1
Submitted name:
    Putative uncharacterized protein EMBL BAE40760.1
    Cyclin D2 EMBL EDK99856.1
Gene names
Name: Ccnd2 MGI 88314
ORF Names: mCG_129731 EMBL EDK99856.1
OrganismMus musculus (Mouse) EMBL CAJ18415.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the cyclin family.

Ontologies

Keywords
   Biological processCell cycle
Cell division RuleBase RU003481V0
   Molecular functionCyclin RuleBase RU000383V1 EMBL EDK99856.1
Gene Ontology (GO)
   Biological processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to insulin stimulus

Inferred from electronic annotation. Source: Compara

liver development

Inferred from electronic annotation. Source: Compara

ovarian follicle development

Inferred from electronic annotation. Source: Compara

positive regulation of cyclin-dependent protein kinase activity

Inferred from electronic annotation. Source: Compara

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of protein amino acid phosphorylation

Inferred from electronic annotation. Source: Compara

regulation of neuron differentiation

Inferred from electronic annotation. Source: Compara

response to cAMP

Inferred from electronic annotation. Source: Compara

response to estradiol stimulus

Inferred from electronic annotation. Source: Compara

response to ethanol

Inferred from electronic annotation. Source: Compara

response to organic cyclic substance

Inferred from electronic annotation. Source: Compara

response to testosterone stimulus

Inferred from electronic annotation. Source: Compara

spermatogenesis

Inferred from electronic annotation. Source: Compara

   Cellular componentcyclin-dependent protein kinase holoenzyme complex

Inferred from electronic annotation. Source: Compara

nucleus

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein kinase binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q4FK45-1 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 58F322771DD1DA3D

FASTA28932,897
        10         20         30         40         50         60 
MELLCCEVDP VRRAVPDRNL LEDRVLQNLL TIEERYLPQC SYFKCVQKDI QPYMRRMVAT 

        70         80         90        100        110        120 
WMLEVCEEQK CEEEVFPLAM NYLDRFLAGV PTPKTHLQLL GAVCMFLASK LKETIPLTAE 

       130        140        150        160        170        180 
KLCIYTDNSV KPQELLEWEL VVLGKLKWNL AAVTPHDFIE HILRKLPQQK EKLSLIRKHA 

       190        200        210        220        230        240 
QTFIALCATD FKFAMYPPSM IATGSVGAAI CGLQQDDEVN TLTCDALTEL LAKITHTDVD 

       250        260        270        280 
CLKACQEQIE ALLLNSLQQF RQEQHNAGSK SVEDPDQATT PTDVRDVDL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDK99856.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDK99856.1.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAE40760.1.
Tissue: Stomach EMBL BAE40760.1 and Head EMBL BAE35987.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK147345 mRNA. Translation: BAE27858.1.
AK160751 mRNA. Translation: BAE35987.1.
AK168954 mRNA. Translation: BAE40760.1.
CT010207 mRNA. Translation: CAJ18415.1.
CH466523 Genomic DNA. Translation: EDK99856.1.
IPIIPI00128318.
RefSeqNP_033959.1.
UniGeneMm.333406

3D structure databases

SMRQ4FK45. Positions 20-253.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4FK45.

Proteomic databases

PRIDEQ4FK45.

Genome annotation databases

EnsemblENSMUST00000000188; ENSMUSP00000000188; ENSMUSG00000000184; Mus musculus. [Genome view]
GeneID12444.
KEGGmmu:12444.
NMPDRfig|10090.3.peg.15296.

Organism-specific databases

CTD12444.
MGIMGI:88314. Ccnd2.

Phylogenomic databases

HOVERGENQ4FK45.
InParanoidQ4FK45.
OMAFMRRMVA.
PhylomeDBQ4FK45.

Gene expression databases

ArrayExpressQ4FK45.
BgeeQ4FK45.
GenevestigatorQ4FK45.

Family and domain databases

InterProIPR015451. CycD.
IPR006670. Cyclin.
IPR011028. Cyclin-like.
IPR014400. Cyclin_A_B_D_E.
IPR004367. Cyclin_C.
IPR006671. Cyclin_N.
IPR013763. Cyclin_related.
[Graphical view]
Gene3DG3DSA:1.10.472.10. Cyclin_related. 1 hit.
PANTHERPTHR10177:SF12. CycD. 1 hit.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio281258.
SOURCESearch...

Entry information

Entry nameQ4FK45_MOUSE
AccessionPrimary (citable) accession number: Q4FK45
Entry history
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information