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Protein
Submitted name:

Ada protein

Gene

Ada

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adenosine catabolic process Source: MGI
  • aging Source: Ensembl
  • dATP catabolic process Source: MGI
  • deoxyadenosine catabolic process Source: MGI
  • embryonic digestive tract development Source: MGI
  • germinal center B cell differentiation Source: MGI
  • histamine secretion Source: Ensembl
  • hypoxanthine biosynthetic process Source: MGI
  • hypoxanthine salvage Source: GO_Central
  • inosine biosynthetic process Source: MGI
  • in utero embryonic development Source: MGI
  • liver development Source: MGI
  • lung alveolus development Source: MGI
  • lung development Source: MGI
  • negative regulation of adenosine receptor signaling pathway Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of leukocyte migration Source: MGI
  • negative regulation of mature B cell apoptotic process Source: MGI
  • negative regulation of mucus secretion Source: MGI
  • negative regulation of penile erection Source: MGI
  • negative regulation of thymocyte apoptotic process Source: MGI
  • Peyer's patch development Source: MGI
  • placenta development Source: MGI
  • positive regulation of alpha-beta T cell differentiation Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of calcium-mediated signaling Source: MGI
  • positive regulation of germinal center formation Source: MGI
  • positive regulation of heart rate Source: MGI
  • positive regulation of smooth muscle contraction Source: MGI
  • positive regulation of T cell activation Source: MGI
  • positive regulation of T cell differentiation Source: MGI
  • positive regulation of T cell differentiation in thymus Source: MGI
  • positive regulation of T cell receptor signaling pathway Source: MGI
  • purine nucleotide salvage Source: MGI
  • purine ribonucleoside monophosphate biosynthetic process Source: InterPro
  • regulation of cell-cell adhesion mediated by integrin Source: MGI
  • regulation of T cell differentiation Source: MGI
  • response to drug Source: Ensembl
  • response to hydrogen peroxide Source: Ensembl
  • response to hypoxia Source: MGI
  • response to morphine Source: Ensembl
  • response to vitamin E Source: Ensembl
  • T cell activation Source: MGI
  • trophectodermal cell differentiation Source: MGI
  • xanthine biosynthetic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ada proteinImported
Submitted name:
Adenosine deaminase, isoform CRA_aImported
Gene namesi
Name:AdaImported
ORF Names:mCG_5441Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87916. Ada.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ4FK28. baseline and differential.
GenevestigatoriQ4FK28.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017841.

Structurei

3D structure databases

ProteinModelPortaliQ4FK28.
SMRiQ4FK28. Positions 4-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00730000111151.
HOVERGENiHBG001718.
KOiK01488.
OMAiLYKAYGM.
PhylomeDBiQ4FK28.

Family and domain databases

HAMAPiMF_00540. A_deaminase.
InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FK28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTPAFNKP KVELHVHLDG AIKPETILYF GKKRGIALPA DTVEELRNII
60 70 80 90 100
GMDKPLSLPG FLAKFDYYMP VIAGCREAIK RIAYEFVEMK AKEGVVYVEV
110 120 130 140 150
RYSPHLLANS KVDPMPWNQT EGDVTPDDVV DLVNQGLQEG EQAFGIKVRS
160 170 180 190 200
ILCCMRHQPS WSLEVLELCK KYNQKTVVAM DLAGDETIEG SSLFPGHVEA
210 220 230 240 250
YEGAVKNGIH RTVHAGEVGS PEVVREAVDI LKTERVGHGY HTIEDEALYN
260 270 280 290 300
RLLKENMHFE VCPWSSYLTG AWDPKTTHAV VRFKNDKANY SLNTDDPLIF
310 320 330 340 350
KSTLDTDYQM TKKDMGFTEE EFKRLNINAA KSSFLPEEEK KELLERLYRE

YQ
Length:352
Mass (Da):39,992
Last modified:August 30, 2005 - v1
Checksum:iE53A8A1FABA148CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010224 mRNA. Translation: CAJ18432.1.
CH466551 Genomic DNA. Translation: EDL06351.1.
CH466551 Genomic DNA. Translation: EDL06352.1.
RefSeqiNP_001258981.1. NM_001272052.1.
NP_031424.1. NM_007398.4.
UniGeneiMm.388.

Genome annotation databases

GeneIDi11486.
KEGGimmu:11486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010224 mRNA. Translation: CAJ18432.1.
CH466551 Genomic DNA. Translation: EDL06351.1.
CH466551 Genomic DNA. Translation: EDL06352.1.
RefSeqiNP_001258981.1. NM_001272052.1.
NP_031424.1. NM_007398.4.
UniGeneiMm.388.

3D structure databases

ProteinModelPortaliQ4FK28.
SMRiQ4FK28. Positions 4-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11486.
KEGGimmu:11486.

Organism-specific databases

CTDi100.
MGIiMGI:87916. Ada.

Phylogenomic databases

GeneTreeiENSGT00730000111151.
HOVERGENiHBG001718.
KOiK01488.
OMAiLYKAYGM.
PhylomeDBiQ4FK28.

Miscellaneous databases

ChiTaRSiAda. mouse.
NextBioi278844.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ4FK28. baseline and differential.
GenevestigatoriQ4FK28.

Family and domain databases

HAMAPiMF_00540. A_deaminase.
InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ4FK28_MOUSE
AccessioniPrimary (citable) accession number: Q4FK28
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: May 27, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.