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Q4FK28 (Q4FK28_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Adenosine deaminase, isoform CRA_a EMBL EDL06351.1
Gene names
Name:Ada MGI 87916 EMBL EDL06351.1
ORF Names:mCG_5441 EMBL EDL06351.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processPeyer's patch development

Inferred from mutant phenotype PubMed 10720488. Source: MGI

T cell activation

Inferred from electronic annotation. Source: Ensembl

adenosine catabolic process

Inferred from direct assay PubMed 1618849PubMed 2015347PubMed 2387582PubMed 7592575PubMed 8663040PubMed 8894685PubMed 9272950. Source: MGI

aging

Inferred from electronic annotation. Source: Ensembl

dATP catabolic process

Inferred from direct assay PubMed 7592575. Source: MGI

deoxyadenosine catabolic process

Inferred from direct assay PubMed 7592575. Source: MGI

embryonic digestive tract development

Inferred from mutant phenotype PubMed 7670465. Source: MGI

germinal center B cell differentiation

Inferred from mutant phenotype PubMed 14607964. Source: MGI

histamine secretion

Inferred from electronic annotation. Source: Ensembl

hypoxanthine biosynthetic process

Inferred from mutant phenotype PubMed 10720488. Source: MGI

hypoxanthine salvage

Inferred from Biological aspect of Ancestor. Source: RefGenome

in utero embryonic development

Inferred from mutant phenotype PubMed 7731963PubMed 9272950. Source: MGI

inosine biosynthetic process

Inferred from direct assay PubMed 1618849PubMed 2015347PubMed 7592575PubMed 8663040PubMed 8894685PubMed 9272950. Source: MGI

liver development

Inferred from mutant phenotype PubMed 7670465PubMed 7731963. Source: MGI

lung alveolus development

Inferred from mutant phenotype PubMed 10899903. Source: MGI

lung development

Inferred from mutant phenotype PubMed 7670465. Source: MGI

negative regulation of adenosine receptor signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 7670465PubMed 8171392. Source: MGI

negative regulation of circadian sleep/wake cycle, non-REM sleep

Inferred from electronic annotation. Source: Ensembl

negative regulation of inflammatory response

Inferred from mutant phenotype PubMed 10899903PubMed 11591798PubMed 15240734PubMed 15630442PubMed 17601796. Source: MGI

negative regulation of leukocyte migration

Inferred from mutant phenotype PubMed 15240734PubMed 15630442. Source: MGI

negative regulation of mature B cell apoptotic process

Inferred from mutant phenotype PubMed 14607964. Source: MGI

negative regulation of mucus secretion

Inferred from mutant phenotype PubMed 15240734PubMed 15630442. Source: MGI

negative regulation of penile erection

Inferred from mutant phenotype PubMed 18340377. Source: MGI

negative regulation of thymocyte apoptotic process

Inferred from mutant phenotype PubMed 11067867PubMed 16670300. Source: MGI

placenta development

Inferred from mutant phenotype PubMed 9272950. Source: MGI

positive regulation of B cell proliferation

Inferred from mutant phenotype PubMed 14607964. Source: MGI

positive regulation of T cell activation

Inferred from mutant phenotype PubMed 10845921PubMed 11435465. Source: MGI

positive regulation of T cell differentiation

Inferred from mutant phenotype PubMed 7731963PubMed 9478961. Source: MGI

positive regulation of T cell differentiation in thymus

Inferred from mutant phenotype PubMed 11067867PubMed 11435465PubMed 12163459PubMed 16670300. Source: MGI

positive regulation of T cell receptor signaling pathway

Inferred from mutant phenotype PubMed 11435465. Source: MGI

positive regulation of alpha-beta T cell differentiation

Inferred from mutant phenotype PubMed 11067867PubMed 12163459PubMed 16670300. Source: MGI

positive regulation of calcium-mediated signaling

Inferred from mutant phenotype PubMed 11435465. Source: MGI

positive regulation of germinal center formation

Inferred from mutant phenotype PubMed 14607964. Source: MGI

positive regulation of heart rate

Inferred from mutant phenotype PubMed 16626672. Source: MGI

positive regulation of smooth muscle contraction

Inferred from mutant phenotype PubMed 18340377. Source: MGI

purine nucleotide salvage

Inferred from electronic annotation. Source: Ensembl

purine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

regulation of T cell differentiation

Inferred from mutant phenotype PubMed 7670465. Source: MGI

regulation of cell-cell adhesion mediated by integrin

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to morphine

Inferred from electronic annotation. Source: Ensembl

response to vitamin E

Inferred from electronic annotation. Source: Ensembl

trophectodermal cell differentiation

Inferred from mutant phenotype PubMed 9272950. Source: MGI

xanthine biosynthetic process

Inferred from mutant phenotype PubMed 10720488. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 11940672PubMed 7691243. Source: MGI

cytosol

Inferred from Biological aspect of Ancestor. Source: RefGenome

dendrite cytoplasm

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

extracellular space

Inferred from electronic annotation. Source: Ensembl

lysosome

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionadenosine deaminase activity

Inferred from direct assay PubMed 1618849PubMed 1914521PubMed 2015347PubMed 2387582PubMed 7592575PubMed 8492116PubMed 8663040PubMed 8894685PubMed 9272950. Source: MGI

purine nucleoside binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q4FK28 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: E53A8A1FABA148CD

FASTA35239,992
        10         20         30         40         50         60 
MAQTPAFNKP KVELHVHLDG AIKPETILYF GKKRGIALPA DTVEELRNII GMDKPLSLPG 

        70         80         90        100        110        120 
FLAKFDYYMP VIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVDPMPWNQT 

       130        140        150        160        170        180 
EGDVTPDDVV DLVNQGLQEG EQAFGIKVRS ILCCMRHQPS WSLEVLELCK KYNQKTVVAM 

       190        200        210        220        230        240 
DLAGDETIEG SSLFPGHVEA YEGAVKNGIH RTVHAGEVGS PEVVREAVDI LKTERVGHGY 

       250        260        270        280        290        300 
HTIEDEALYN RLLKENMHFE VCPWSSYLTG AWDPKTTHAV VRFKNDKANY SLNTDDPLIF 

       310        320        330        340        350 
KSTLDTDYQM TKKDMGFTEE EFKRLNINAA KSSFLPEEEK KELLERLYRE YQ 

« Hide

References

[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL06351.1.
[2]"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL06351.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT010224 mRNA. Translation: CAJ18432.1.
CH466551 Genomic DNA. Translation: EDL06351.1.
CH466551 Genomic DNA. Translation: EDL06352.1.
RefSeqNP_001258981.1. NM_001272052.1.
NP_031424.1. NM_007398.4.
UniGeneMm.388.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000017841.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11486.
KEGGmmu:11486.

Organism-specific databases

CTD100.
MGIMGI:87916. Ada.

Phylogenomic databases

GeneTreeENSGT00730000111151.
HOVERGENHBG001718.
InParanoidQ4FK28.
KOK01488.
OMADWMVAVL.

Gene expression databases

GenevestigatorQ4FK28.

Family and domain databases

HAMAPMF_00540. A_deaminase.
InterProIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
[Graphical view]
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSADA. mouse.
NextBio278844.
SOURCESearch...

Entry information

Entry nameQ4FK28_MOUSE
AccessionPrimary (citable) accession number: Q4FK28
Entry history
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)