Q4FK28 (Q4FK28_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ada protein EMBL CAJ18432.1

Submitted name:
Adenosine deaminase, isoform CRA_a EMBL EDL06351.1

Gene names

Name:	Ada MGI 87916 EMBL EDL06351.1
ORF Names:	mCG_5441 EMBL EDL06351.1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	Peyer's patch development Inferred from mutant phenotype PubMed 10720488. Source: MGI T cell activation Inferred from electronic annotation. Source: Compara adenosine catabolic process Inferred from direct assay PubMed 1618849PubMed 2015347PubMed 2387582PubMed 7592575PubMed 8663040PubMed 8894685PubMed 9272950. Source: MGI aging Inferred from electronic annotation. Source: Compara dATP catabolic process Inferred from direct assay PubMed 7592575. Source: MGI deoxyadenosine catabolic process Inferred from direct assay PubMed 7592575. Source: MGI embryonic digestive tract development Inferred from mutant phenotype PubMed 7670465. Source: MGI germinal center B cell differentiation Inferred from mutant phenotype PubMed 14607964. Source: MGI histamine secretion Inferred from electronic annotation. Source: Compara hypoxanthine salvage Inferred from Biological aspect of Ancestor. Source: RefGenome inosine biosynthetic process Inferred from direct assay PubMed 1618849PubMed 2015347PubMed 7592575PubMed 8663040PubMed 8894685PubMed 9272950. Source: MGI liver development Inferred from mutant phenotype PubMed 7670465PubMed 7731963. Source: MGI lung alveolus development Inferred from mutant phenotype PubMed 10899903. Source: MGI negative regulation of adenosine receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of circadian sleep/wake cycle, non-REM sleep Inferred from electronic annotation. Source: Compara negative regulation of inflammatory response Inferred from mutant phenotype PubMed 10899903PubMed 11591798PubMed 15240734PubMed 15630442PubMed 17601796. Source: MGI negative regulation of leukocyte migration Inferred from mutant phenotype PubMed 15240734PubMed 15630442. Source: MGI negative regulation of mature B cell apoptotic process Inferred from mutant phenotype PubMed 14607964. Source: MGI negative regulation of mucus secretion Inferred from mutant phenotype PubMed 15240734PubMed 15630442. Source: MGI negative regulation of penile erection Inferred from mutant phenotype PubMed 18340377. Source: MGI negative regulation of thymocyte apoptotic process Inferred from mutant phenotype PubMed 11067867PubMed 16670300. Source: MGI placenta development Inferred from mutant phenotype PubMed 9272950. Source: MGI positive regulation of B cell proliferation Inferred from mutant phenotype PubMed 14607964. Source: MGI positive regulation of T cell differentiation in thymus Inferred from mutant phenotype PubMed 11067867PubMed 11435465PubMed 12163459PubMed 16670300. Source: MGI positive regulation of T cell receptor signaling pathway Inferred from mutant phenotype PubMed 11435465. Source: MGI positive regulation of alpha-beta T cell differentiation Inferred from mutant phenotype PubMed 11067867PubMed 12163459PubMed 16670300. Source: MGI positive regulation of calcium-mediated signaling Inferred from mutant phenotype PubMed 11435465. Source: MGI positive regulation of germinal center formation Inferred from mutant phenotype PubMed 14607964. Source: MGI positive regulation of heart rate Inferred from mutant phenotype PubMed 16626672. Source: MGI positive regulation of smooth muscle contraction Inferred from mutant phenotype PubMed 18340377. Source: MGI purine nucleotide salvage Inferred from electronic annotation. Source: Compara purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro regulation of cell-cell adhesion mediated by integrin Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to morphine Inferred from electronic annotation. Source: Compara trophectodermal cell differentiation Inferred from mutant phenotype PubMed 9272950. Source: MGI xanthine biosynthetic process Inferred from mutant phenotype PubMed 10720488. Source: MGI
Cellular_component	cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome dendrite cytoplasm Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular space Inferred from electronic annotation. Source: Compara lysosome Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara
Molecular_function	adenosine deaminase activity Inferred from direct assay PubMed 1618849PubMed 1914521PubMed 2015347PubMed 2387582PubMed 7592575PubMed 8492116PubMed 8663040PubMed 8894685PubMed 9272950. Source: MGI purine nucleoside binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4FK28 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: E53A8A1FABA148CD	FASTA	352	39,992
	10 20 30 40 50 60 MAQTPAFNKP KVELHVHLDG AIKPETILYF GKKRGIALPA DTVEELRNII GMDKPLSLPG 70 80 90 100 110 120 FLAKFDYYMP VIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVDPMPWNQT 130 140 150 160 170 180 EGDVTPDDVV DLVNQGLQEG EQAFGIKVRS ILCCMRHQPS WSLEVLELCK KYNQKTVVAM 190 200 210 220 230 240 DLAGDETIEG SSLFPGHVEA YEGAVKNGIH RTVHAGEVGS PEVVREAVDI LKTERVGHGY 250 260 270 280 290 300 HTIEDEALYN RLLKENMHFE VCPWSSYLTG AWDPKTTHAV VRFKNDKANY SLNTDDPLIF 310 320 330 340 350 KSTLDTDYQM TKKDMGFTEE EFKRLNINAA KSSFLPEEEK KELLERLYRE YQ

References

[1]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL06351.1.
[2]	"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)." Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL06351.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT010224 mRNA. Translation: CAJ18432.1. CH466551 Genomic DNA. Translation: EDL06351.1. CH466551 Genomic DNA. Translation: EDL06352.1.
IPI	IPI00261467.
RefSeq	NP_001258981.1. NM_001272052.1. NP_031424.1. NM_007398.4.
UniGene	Mm.388.
3D structure databases
SMR	Q4FK28. Positions 4-352.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000017841.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	11486.
KEGG	mmu:11486.
UCSC	uc008ntl.1. mouse.
Organism-specific databases
CTD	100.
MGI	MGI:87916. Ada.
Phylogenomic databases
GeneTree	ENSGT00640000091458.
HOVERGEN	HBG001718.
InParanoid	Q4FK28.
KO	K01488.
OMA	MPAIAGC.
Gene expression databases
Genevestigator	Q4FK28.
Family and domain databases
HAMAP	MF_00540. A_deaminase.
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase_dom. IPR006330. Ado/ade_deaminase. [Graphical view]
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ADA. mouse.
NextBio	278844.
SOURCE	Search...

Entry information

Entry name

Q4FK28_MOUSE

Accession

Primary (citable) accession number: Q4FK28

Entry history

Integrated into UniProtKB/TrEMBL:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)