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Q4FK28

- Q4FK28_MOUSE

UniProt

Q4FK28 - Q4FK28_MOUSE

Protein
Submitted name:

Ada protein

Gene

Ada

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. adenosine deaminase activity Source: MGI
    2. purine nucleoside binding Source: Ensembl

    GO - Biological processi

    1. adenosine catabolic process Source: MGI
    2. aging Source: Ensembl
    3. dATP catabolic process Source: MGI
    4. deoxyadenosine catabolic process Source: MGI
    5. embryonic digestive tract development Source: MGI
    6. germinal center B cell differentiation Source: MGI
    7. histamine secretion Source: Ensembl
    8. hypoxanthine biosynthetic process Source: MGI
    9. hypoxanthine salvage Source: RefGenome
    10. inosine biosynthetic process Source: MGI
    11. in utero embryonic development Source: MGI
    12. liver development Source: MGI
    13. lung alveolus development Source: MGI
    14. lung development Source: MGI
    15. negative regulation of adenosine receptor signaling pathway Source: RefGenome
    16. negative regulation of apoptotic process Source: MGI
    17. negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
    18. negative regulation of inflammatory response Source: MGI
    19. negative regulation of leukocyte migration Source: MGI
    20. negative regulation of mature B cell apoptotic process Source: MGI
    21. negative regulation of mucus secretion Source: MGI
    22. negative regulation of penile erection Source: MGI
    23. negative regulation of thymocyte apoptotic process Source: MGI
    24. Peyer's patch development Source: MGI
    25. placenta development Source: MGI
    26. positive regulation of alpha-beta T cell differentiation Source: MGI
    27. positive regulation of B cell proliferation Source: MGI
    28. positive regulation of calcium-mediated signaling Source: MGI
    29. positive regulation of germinal center formation Source: MGI
    30. positive regulation of heart rate Source: MGI
    31. positive regulation of smooth muscle contraction Source: MGI
    32. positive regulation of T cell activation Source: MGI
    33. positive regulation of T cell differentiation Source: MGI
    34. positive regulation of T cell differentiation in thymus Source: MGI
    35. positive regulation of T cell receptor signaling pathway Source: MGI
    36. purine nucleotide salvage Source: Ensembl
    37. purine ribonucleoside monophosphate biosynthetic process Source: InterPro
    38. regulation of cell-cell adhesion mediated by integrin Source: Ensembl
    39. regulation of T cell differentiation Source: MGI
    40. response to drug Source: Ensembl
    41. response to hydrogen peroxide Source: Ensembl
    42. response to hypoxia Source: Ensembl
    43. response to morphine Source: Ensembl
    44. response to vitamin E Source: Ensembl
    45. T cell activation Source: Ensembl
    46. trophectodermal cell differentiation Source: MGI
    47. xanthine biosynthetic process Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ada proteinImported
    Submitted name:
    Adenosine deaminase, isoform CRA_aImported
    Gene namesi
    Name:AdaImported
    ORF Names:mCG_5441Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:87916. Ada.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: RefGenome
    3. dendrite cytoplasm Source: Ensembl
    4. external side of plasma membrane Source: RefGenome
    5. extracellular space Source: Ensembl
    6. lysosome Source: Ensembl
    7. neuronal cell body Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ4FK28.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000017841.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00730000111151.
    HOVERGENiHBG001718.
    InParanoidiQ4FK28.
    KOiK01488.
    OMAiDWMVAVL.

    Family and domain databases

    HAMAPiMF_00540. A_deaminase.
    InterProiIPR006650. A/AMP_deam_AS.
    IPR001365. A/AMP_deaminase_dom.
    IPR028893. A_deaminase.
    IPR006330. Ado/ade_deaminase.
    [Graphical view]
    PfamiPF00962. A_deaminase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01430. aden_deam. 1 hit.
    PROSITEiPS00485. A_DEAMINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FK28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQTPAFNKP KVELHVHLDG AIKPETILYF GKKRGIALPA DTVEELRNII    50
    GMDKPLSLPG FLAKFDYYMP VIAGCREAIK RIAYEFVEMK AKEGVVYVEV 100
    RYSPHLLANS KVDPMPWNQT EGDVTPDDVV DLVNQGLQEG EQAFGIKVRS 150
    ILCCMRHQPS WSLEVLELCK KYNQKTVVAM DLAGDETIEG SSLFPGHVEA 200
    YEGAVKNGIH RTVHAGEVGS PEVVREAVDI LKTERVGHGY HTIEDEALYN 250
    RLLKENMHFE VCPWSSYLTG AWDPKTTHAV VRFKNDKANY SLNTDDPLIF 300
    KSTLDTDYQM TKKDMGFTEE EFKRLNINAA KSSFLPEEEK KELLERLYRE 350
    YQ 352
    Length:352
    Mass (Da):39,992
    Last modified:August 30, 2005 - v1
    Checksum:iE53A8A1FABA148CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010224 mRNA. Translation: CAJ18432.1.
    CH466551 Genomic DNA. Translation: EDL06351.1.
    CH466551 Genomic DNA. Translation: EDL06352.1.
    RefSeqiNP_001258981.1. NM_001272052.1.
    NP_031424.1. NM_007398.4.
    UniGeneiMm.388.

    Genome annotation databases

    GeneIDi11486.
    KEGGimmu:11486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010224 mRNA. Translation: CAJ18432.1 .
    CH466551 Genomic DNA. Translation: EDL06351.1 .
    CH466551 Genomic DNA. Translation: EDL06352.1 .
    RefSeqi NP_001258981.1. NM_001272052.1.
    NP_031424.1. NM_007398.4.
    UniGenei Mm.388.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000017841.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11486.
    KEGGi mmu:11486.

    Organism-specific databases

    CTDi 100.
    MGIi MGI:87916. Ada.

    Phylogenomic databases

    GeneTreei ENSGT00730000111151.
    HOVERGENi HBG001718.
    InParanoidi Q4FK28.
    KOi K01488.
    OMAi DWMVAVL.

    Miscellaneous databases

    ChiTaRSi ADA. mouse.
    NextBioi 278844.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q4FK28.

    Family and domain databases

    HAMAPi MF_00540. A_deaminase.
    InterProi IPR006650. A/AMP_deam_AS.
    IPR001365. A/AMP_deaminase_dom.
    IPR028893. A_deaminase.
    IPR006330. Ado/ade_deaminase.
    [Graphical view ]
    Pfami PF00962. A_deaminase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01430. aden_deam. 1 hit.
    PROSITEi PS00485. A_DEAMINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ4FK28_MOUSE
    AccessioniPrimary (citable) accession number: Q4FK28
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 30, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)