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Protein
Submitted name:

Ada protein

Gene

Ada

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. adenosine deaminase activity Source: MGI
  2. purine nucleoside binding Source: Ensembl
  3. zinc ion binding Source: MGI

GO - Biological processi

  1. adenosine catabolic process Source: MGI
  2. aging Source: Ensembl
  3. dATP catabolic process Source: MGI
  4. deoxyadenosine catabolic process Source: MGI
  5. embryonic digestive tract development Source: MGI
  6. germinal center B cell differentiation Source: MGI
  7. histamine secretion Source: Ensembl
  8. hypoxanthine biosynthetic process Source: MGI
  9. hypoxanthine salvage Source: GO_Central
  10. inosine biosynthetic process Source: MGI
  11. in utero embryonic development Source: MGI
  12. liver development Source: MGI
  13. lung alveolus development Source: MGI
  14. lung development Source: MGI
  15. negative regulation of adenosine receptor signaling pathway Source: MGI
  16. negative regulation of apoptotic process Source: MGI
  17. negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  18. negative regulation of inflammatory response Source: MGI
  19. negative regulation of leukocyte migration Source: MGI
  20. negative regulation of mature B cell apoptotic process Source: MGI
  21. negative regulation of mucus secretion Source: MGI
  22. negative regulation of penile erection Source: MGI
  23. negative regulation of thymocyte apoptotic process Source: MGI
  24. Peyer's patch development Source: MGI
  25. placenta development Source: MGI
  26. positive regulation of alpha-beta T cell differentiation Source: MGI
  27. positive regulation of B cell proliferation Source: MGI
  28. positive regulation of calcium-mediated signaling Source: MGI
  29. positive regulation of germinal center formation Source: MGI
  30. positive regulation of heart rate Source: MGI
  31. positive regulation of smooth muscle contraction Source: MGI
  32. positive regulation of T cell activation Source: MGI
  33. positive regulation of T cell differentiation Source: MGI
  34. positive regulation of T cell differentiation in thymus Source: MGI
  35. positive regulation of T cell receptor signaling pathway Source: MGI
  36. purine nucleotide salvage Source: MGI
  37. purine ribonucleoside monophosphate biosynthetic process Source: InterPro
  38. regulation of cell-cell adhesion mediated by integrin Source: MGI
  39. regulation of T cell differentiation Source: MGI
  40. response to drug Source: Ensembl
  41. response to hydrogen peroxide Source: Ensembl
  42. response to hypoxia Source: MGI
  43. response to morphine Source: Ensembl
  44. response to vitamin E Source: Ensembl
  45. T cell activation Source: MGI
  46. trophectodermal cell differentiation Source: MGI
  47. xanthine biosynthetic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ada proteinImported
Submitted name:
Adenosine deaminase, isoform CRA_aImported
Gene namesi
Name:AdaImported
ORF Names:mCG_5441Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87916. Ada.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. cytoplasm Source: MGI
  3. cytosol Source: GO_Central
  4. dendrite cytoplasm Source: Ensembl
  5. external side of plasma membrane Source: MGI
  6. extracellular space Source: Ensembl
  7. lysosome Source: MGI
  8. membrane Source: MGI
  9. neuronal cell body Source: Ensembl
  10. plasma membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ4FK28.

Expressioni

Gene expression databases

BgeeiQ4FK28.
ExpressionAtlasiQ4FK28. baseline and differential.
GenevestigatoriQ4FK28.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017841.

Structurei

3D structure databases

ProteinModelPortaliQ4FK28.
SMRiQ4FK28. Positions 4-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00730000111151.
HOVERGENiHBG001718.
KOiK01488.
OMAiLYKAYGM.
PhylomeDBiQ4FK28.

Family and domain databases

HAMAPiMF_00540. A_deaminase.
InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FK28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTPAFNKP KVELHVHLDG AIKPETILYF GKKRGIALPA DTVEELRNII
60 70 80 90 100
GMDKPLSLPG FLAKFDYYMP VIAGCREAIK RIAYEFVEMK AKEGVVYVEV
110 120 130 140 150
RYSPHLLANS KVDPMPWNQT EGDVTPDDVV DLVNQGLQEG EQAFGIKVRS
160 170 180 190 200
ILCCMRHQPS WSLEVLELCK KYNQKTVVAM DLAGDETIEG SSLFPGHVEA
210 220 230 240 250
YEGAVKNGIH RTVHAGEVGS PEVVREAVDI LKTERVGHGY HTIEDEALYN
260 270 280 290 300
RLLKENMHFE VCPWSSYLTG AWDPKTTHAV VRFKNDKANY SLNTDDPLIF
310 320 330 340 350
KSTLDTDYQM TKKDMGFTEE EFKRLNINAA KSSFLPEEEK KELLERLYRE

YQ
Length:352
Mass (Da):39,992
Last modified:August 30, 2005 - v1
Checksum:iE53A8A1FABA148CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010224 mRNA. Translation: CAJ18432.1.
CH466551 Genomic DNA. Translation: EDL06351.1.
CH466551 Genomic DNA. Translation: EDL06352.1.
RefSeqiNP_001258981.1. NM_001272052.1.
NP_031424.1. NM_007398.4.
UniGeneiMm.388.

Genome annotation databases

GeneIDi11486.
KEGGimmu:11486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010224 mRNA. Translation: CAJ18432.1.
CH466551 Genomic DNA. Translation: EDL06351.1.
CH466551 Genomic DNA. Translation: EDL06352.1.
RefSeqiNP_001258981.1. NM_001272052.1.
NP_031424.1. NM_007398.4.
UniGeneiMm.388.

3D structure databases

ProteinModelPortaliQ4FK28.
SMRiQ4FK28. Positions 4-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017841.

Chemistry

BindingDBiQ4FK28.

Proteomic databases

PRIDEiQ4FK28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11486.
KEGGimmu:11486.

Organism-specific databases

CTDi100.
MGIiMGI:87916. Ada.

Phylogenomic databases

GeneTreeiENSGT00730000111151.
HOVERGENiHBG001718.
KOiK01488.
OMAiLYKAYGM.
PhylomeDBiQ4FK28.

Miscellaneous databases

ChiTaRSiAda. mouse.
NextBioi278844.
SOURCEiSearch...

Gene expression databases

BgeeiQ4FK28.
ExpressionAtlasiQ4FK28. baseline and differential.
GenevestigatoriQ4FK28.

Family and domain databases

HAMAPiMF_00540. A_deaminase.
InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ4FK28_MOUSE
AccessioniPrimary (citable) accession number: Q4FK28
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: April 1, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.