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Q4FK28

- Q4FK28_MOUSE

UniProt

Q4FK28 - Q4FK28_MOUSE

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Protein
Submitted name:

Ada protein

Gene

Ada

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. adenosine deaminase activity Source: MGI
  2. purine nucleoside binding Source: Ensembl

GO - Biological processi

  1. adenosine catabolic process Source: MGI
  2. aging Source: Ensembl
  3. dATP catabolic process Source: MGI
  4. deoxyadenosine catabolic process Source: MGI
  5. embryonic digestive tract development Source: MGI
  6. germinal center B cell differentiation Source: MGI
  7. histamine secretion Source: Ensembl
  8. hypoxanthine biosynthetic process Source: MGI
  9. hypoxanthine salvage Source: RefGenome
  10. inosine biosynthetic process Source: MGI
  11. in utero embryonic development Source: MGI
  12. liver development Source: MGI
  13. lung alveolus development Source: MGI
  14. lung development Source: MGI
  15. negative regulation of adenosine receptor signaling pathway Source: RefGenome
  16. negative regulation of apoptotic process Source: MGI
  17. negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  18. negative regulation of inflammatory response Source: MGI
  19. negative regulation of leukocyte migration Source: MGI
  20. negative regulation of mature B cell apoptotic process Source: MGI
  21. negative regulation of mucus secretion Source: MGI
  22. negative regulation of penile erection Source: MGI
  23. negative regulation of thymocyte apoptotic process Source: MGI
  24. Peyer's patch development Source: MGI
  25. placenta development Source: MGI
  26. positive regulation of alpha-beta T cell differentiation Source: MGI
  27. positive regulation of B cell proliferation Source: MGI
  28. positive regulation of calcium-mediated signaling Source: MGI
  29. positive regulation of germinal center formation Source: MGI
  30. positive regulation of heart rate Source: MGI
  31. positive regulation of smooth muscle contraction Source: MGI
  32. positive regulation of T cell activation Source: MGI
  33. positive regulation of T cell differentiation Source: MGI
  34. positive regulation of T cell differentiation in thymus Source: MGI
  35. positive regulation of T cell receptor signaling pathway Source: MGI
  36. purine nucleotide salvage Source: Ensembl
  37. purine ribonucleoside monophosphate biosynthetic process Source: InterPro
  38. regulation of cell-cell adhesion mediated by integrin Source: Ensembl
  39. regulation of T cell differentiation Source: MGI
  40. response to drug Source: Ensembl
  41. response to hydrogen peroxide Source: Ensembl
  42. response to hypoxia Source: Ensembl
  43. response to morphine Source: Ensembl
  44. response to vitamin E Source: Ensembl
  45. T cell activation Source: Ensembl
  46. trophectodermal cell differentiation Source: MGI
  47. xanthine biosynthetic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ada proteinImported
Submitted name:
Adenosine deaminase, isoform CRA_aImported
Gene namesi
Name:AdaImported
ORF Names:mCG_5441Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87916. Ada.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: RefGenome
  3. dendrite cytoplasm Source: Ensembl
  4. external side of plasma membrane Source: RefGenome
  5. extracellular space Source: Ensembl
  6. lysosome Source: Ensembl
  7. neuronal cell body Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ4FK28.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017841.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00730000111151.
HOVERGENiHBG001718.
KOiK01488.
OMAiDWMVAVL.

Family and domain databases

HAMAPiMF_00540. A_deaminase.
InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FK28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQTPAFNKP KVELHVHLDG AIKPETILYF GKKRGIALPA DTVEELRNII
60 70 80 90 100
GMDKPLSLPG FLAKFDYYMP VIAGCREAIK RIAYEFVEMK AKEGVVYVEV
110 120 130 140 150
RYSPHLLANS KVDPMPWNQT EGDVTPDDVV DLVNQGLQEG EQAFGIKVRS
160 170 180 190 200
ILCCMRHQPS WSLEVLELCK KYNQKTVVAM DLAGDETIEG SSLFPGHVEA
210 220 230 240 250
YEGAVKNGIH RTVHAGEVGS PEVVREAVDI LKTERVGHGY HTIEDEALYN
260 270 280 290 300
RLLKENMHFE VCPWSSYLTG AWDPKTTHAV VRFKNDKANY SLNTDDPLIF
310 320 330 340 350
KSTLDTDYQM TKKDMGFTEE EFKRLNINAA KSSFLPEEEK KELLERLYRE

YQ
Length:352
Mass (Da):39,992
Last modified:August 30, 2005 - v1
Checksum:iE53A8A1FABA148CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010224 mRNA. Translation: CAJ18432.1.
CH466551 Genomic DNA. Translation: EDL06351.1.
CH466551 Genomic DNA. Translation: EDL06352.1.
RefSeqiNP_001258981.1. NM_001272052.1.
NP_031424.1. NM_007398.4.
UniGeneiMm.388.

Genome annotation databases

GeneIDi11486.
KEGGimmu:11486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010224 mRNA. Translation: CAJ18432.1 .
CH466551 Genomic DNA. Translation: EDL06351.1 .
CH466551 Genomic DNA. Translation: EDL06352.1 .
RefSeqi NP_001258981.1. NM_001272052.1.
NP_031424.1. NM_007398.4.
UniGenei Mm.388.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000017841.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 11486.
KEGGi mmu:11486.

Organism-specific databases

CTDi 100.
MGIi MGI:87916. Ada.

Phylogenomic databases

GeneTreei ENSGT00730000111151.
HOVERGENi HBG001718.
KOi K01488.
OMAi DWMVAVL.

Miscellaneous databases

ChiTaRSi Ada. mouse.
NextBioi 278844.
SOURCEi Search...

Gene expression databases

Genevestigatori Q4FK28.

Family and domain databases

HAMAPi MF_00540. A_deaminase.
InterProi IPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
[Graphical view ]
Pfami PF00962. A_deaminase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01430. aden_deam. 1 hit.
PROSITEi PS00485. A_DEAMINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ4FK28_MOUSE
AccessioniPrimary (citable) accession number: Q4FK28
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)