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Q4FJX9 (Q4FJX9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase RuleBase RU000414

EC=1.15.1.1 RuleBase RU000414
Gene names
Name:Sod2 MGI 98352 EMBL EDL02018.1
ORF Names:mCG_16695 EMBL EDL02018.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity. RuleBase RU000414

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2. RuleBase RU000414

Sequence similarities

Belongs to the iron/manganese superoxide dismutase family. RuleBase RU004477

Ontologies

Keywords
   Molecular functionOxidoreductase RuleBase RU000414
Gene Ontology (GO)
   Biological_processage-dependent response to oxidative stress

Inferred from mutant phenotype PubMed 11226230. Source: MGI

age-dependent response to reactive oxygen species

Inferred from electronic annotation. Source: Ensembl

apoptotic mitochondrial changes

Inferred from mutant phenotype PubMed 11226230. Source: MGI

cellular response to ethanol

Inferred from electronic annotation. Source: Ensembl

detection of oxygen

Inferred from mutant phenotype PubMed 11156968. Source: MGI

erythrophore differentiation

Inferred from mutant phenotype PubMed 15205258. Source: MGI

glutathione metabolic process

Inferred from mutant phenotype PubMed 10049502. Source: MGI

heart development

Inferred from mutant phenotype PubMed 7493016. Source: MGI

hemopoiesis

Inferred from mutant phenotype PubMed 16219542PubMed 8790408. Source: MGI

hydrogen peroxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from mutant phenotype PubMed 15642323. Source: MGI

intrinsic apoptotic signaling pathway in response to oxidative stress

Inferred from mutant phenotype PubMed 15642323. Source: MGI

iron ion homeostasis

Inferred from mutant phenotype PubMed 15205258. Source: MGI

liver development

Inferred from mutant phenotype PubMed 17367743. Source: MGI

locomotory behavior

Inferred from mutant phenotype PubMed 8790408. Source: MGI

mitochondrion organization

Inferred from mutant phenotype PubMed 11527927PubMed 15205258PubMed 8790408. Source: MGI

negative regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 16219542. Source: MGI

negative regulation of fibroblast proliferation

Inferred from direct assay PubMed 18218638. Source: MGI

negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

neuron development

Inferred from mutant phenotype PubMed 8790408. Source: MGI

oxygen homeostasis

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Inferred from mutant phenotype PubMed 15637112. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 7493016PubMed 8790408. Source: MGI

protein homotetramerization

Inferred from electronic annotation. Source: Ensembl

regulation of blood pressure

Inferred from mutant phenotype PubMed 17023572. Source: MGI

regulation of catalytic activity

Inferred from mutant phenotype PubMed 9927656. Source: MGI

regulation of mitochondrial membrane potential

Inferred from mutant phenotype PubMed 17367743. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 17670746. Source: MGI

release of cytochrome c from mitochondria

Inferred from mutant phenotype PubMed 10212301PubMed 15642323. Source: MGI

removal of superoxide radicals

Inferred from mutant phenotype PubMed 16873728. Source: MGI

respiratory electron transport chain

Inferred from mutant phenotype PubMed 11226230PubMed 19478076. Source: MGI

response to L-ascorbic acid

Inferred from electronic annotation. Source: Ensembl

response to activity

Inferred from mutant phenotype PubMed 15781740. Source: MGI

response to axon injury

Inferred from mutant phenotype PubMed 16677818. Source: MGI

response to cadmium ion

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to electrical stimulus

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from genetic interaction PubMed 15182862. Source: MGI

response to hydrogen peroxide

Inferred from mutant phenotype PubMed 15642323. Source: MGI

response to hyperoxia

Inferred from mutant phenotype PubMed 11796207. Source: MGI

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to manganese ion

Inferred from electronic annotation. Source: Ensembl

response to oxidative stress

Inferred from mutant phenotype PubMed 15182862PubMed 19478076. Source: MGI

response to reactive oxygen species

Inferred from mutant phenotype PubMed 15205258PubMed 16219542PubMed 17145560PubMed 9462746PubMed 9927656. Source: MGI

response to selenium ion

Inferred from electronic annotation. Source: Ensembl

response to silicon dioxide

Inferred from electronic annotation. Source: Ensembl

response to superoxide

Inferred from mutant phenotype PubMed 11156968PubMed 15642323. Source: MGI

response to zinc ion

Inferred from electronic annotation. Source: Ensembl

superoxide anion generation

Inferred from mutant phenotype PubMed 10212301PubMed 15781740PubMed 16677818. Source: MGI

superoxide metabolic process

Inferred from mutant phenotype PubMed 10049502PubMed 12176043PubMed 15637112. Source: MGI

vasodilation

Inferred from mutant phenotype PubMed 15637112. Source: MGI

vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure

Inferred from mutant phenotype PubMed 16873728. Source: MGI

   Cellular_componentmitochondrial inner membrane

Inferred from direct assay PubMed 12865426. Source: MGI

mitochondrial nucleoid

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from direct assay PubMed 11583975PubMed 12931191PubMed 14651853PubMed 16103131PubMed 17597094PubMed 18614015PubMed 22474353. Source: MGI

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: InterPro

oxygen binding

Inferred from electronic annotation. Source: Ensembl

superoxide dismutase activity

Inferred from direct assay PubMed 12646716PubMed 18218638PubMed 7333654PubMed 9651187. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q4FJX9 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 9AE804C55A8357D9

FASTA22224,603
        10         20         30         40         50         60 
MLCRAACSTG RRLGPVAGAA GSRHKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 

        70         80         90        100        110        120 
NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI FWTNLSPKGG GEPKGELLEA 

       130        140        150        160        170        180 
IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL 

       190        200        210        220 
GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYTAC KK 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1.
Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1.
Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1.
Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1.
Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1.
Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[6]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL02018.1.
[7]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22531.1.
Tissue: Mullerian duct includes surrounding region EMBL BAE22531.1.
[8]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE40460.1 and DBA/2 EMBL BAE40055.1.
Tissue: Heart EMBL BAE40460.1.
[9]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1.
Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[10]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1.
Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[11]"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[12]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL02018.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK135435 mRNA. Translation: BAE22531.1.
AK168082 mRNA. Translation: BAE40055.1.
AK168591 mRNA. Translation: BAE40460.1.
CT010273 mRNA. Translation: CAJ18481.1.
CH466619 Genomic DNA. Translation: EDL02018.1.
RefSeqNP_038699.2. NM_013671.3.
UniGeneMm.290876.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID20656.
KEGGmmu:20656.

Organism-specific databases

CTD6648.
MGIMGI:98352. Sod2.

Phylogenomic databases

GeneTreeENSGT00390000011877.
HOVERGENHBG004451.
InParanoidQ4FJX9.
KOK04564.
OMATERYTAC.

Gene expression databases

GenevestigatorQ4FJX9.

Family and domain databases

InterProIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERPTHR11404. PTHR11404. 1 hit.
PfamPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFPIRSF000349. SODismutase. 1 hit.
PRINTSPR01703. MNSODISMTASE.
SUPFAMSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSOD2. mouse.
NextBio299085.
SOURCESearch...

Entry information

Entry nameQ4FJX9_MOUSE
AccessionPrimary (citable) accession number: Q4FJX9
Entry history
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)