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Q4FJX9

- Q4FJX9_MOUSE

UniProt

Q4FJX9 - Q4FJX9_MOUSE

Protein

Superoxide dismutase

Gene

Sod2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: Ensembl
    2. metal ion binding Source: InterPro
    3. oxygen binding Source: Ensembl
    4. superoxide dismutase activity Source: MGI

    GO - Biological processi

    1. age-dependent response to oxidative stress Source: MGI
    2. age-dependent response to reactive oxygen species Source: Ensembl
    3. apoptotic mitochondrial changes Source: MGI
    4. cellular response to ethanol Source: Ensembl
    5. detection of oxygen Source: MGI
    6. erythrophore differentiation Source: MGI
    7. glutathione metabolic process Source: MGI
    8. heart development Source: MGI
    9. hemopoiesis Source: MGI
    10. hydrogen peroxide biosynthetic process Source: Ensembl
    11. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    12. intrinsic apoptotic signaling pathway in response to oxidative stress Source: MGI
    13. iron ion homeostasis Source: MGI
    14. liver development Source: MGI
    15. locomotory behavior Source: MGI
    16. mitochondrion organization Source: MGI
    17. negative regulation of fat cell differentiation Source: MGI
    18. negative regulation of fibroblast proliferation Source: MGI
    19. negative regulation of neuron apoptotic process Source: Ensembl
    20. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
    21. neuron development Source: MGI
    22. oxygen homeostasis Source: Ensembl
    23. positive regulation of nitric oxide biosynthetic process Source: MGI
    24. post-embryonic development Source: MGI
    25. protein homotetramerization Source: Ensembl
    26. regulation of blood pressure Source: MGI
    27. regulation of catalytic activity Source: MGI
    28. regulation of mitochondrial membrane potential Source: MGI
    29. regulation of transcription from RNA polymerase II promoter Source: MGI
    30. release of cytochrome c from mitochondria Source: MGI
    31. removal of superoxide radicals Source: MGI
    32. respiratory electron transport chain Source: MGI
    33. response to activity Source: MGI
    34. response to axon injury Source: MGI
    35. response to cadmium ion Source: Ensembl
    36. response to drug Source: Ensembl
    37. response to electrical stimulus Source: Ensembl
    38. response to gamma radiation Source: MGI
    39. response to hydrogen peroxide Source: MGI
    40. response to hyperoxia Source: MGI
    41. response to hypoxia Source: Ensembl
    42. response to L-ascorbic acid Source: Ensembl
    43. response to lipopolysaccharide Source: Ensembl
    44. response to manganese ion Source: Ensembl
    45. response to oxidative stress Source: MGI
    46. response to reactive oxygen species Source: MGI
    47. response to selenium ion Source: Ensembl
    48. response to silicon dioxide Source: Ensembl
    49. response to superoxide Source: MGI
    50. response to zinc ion Source: Ensembl
    51. superoxide anion generation Source: MGI
    52. superoxide metabolic process Source: MGI
    53. vasodilation Source: MGI
    54. vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure Source: MGI

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
    Gene namesi
    Name:Sod2Imported
    ORF Names:mCG_16695Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:98352. Sod2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: MGI
    2. mitochondrial nucleoid Source: Ensembl
    3. mitochondrion Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ4FJX9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000011877.
    HOVERGENiHBG004451.
    InParanoidiQ4FJX9.
    KOiK04564.
    OMAiTERYTAC.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FJX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLCRAACSTG RRLGPVAGAA GSRHKHSLPD LPYDYGALEP HINAQIMQLH    50
    HSKHHAAYVN NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI 100
    FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL 150
    GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY 200
    LKAIWNVINW ENVTERYTAC KK 222
    Length:222
    Mass (Da):24,603
    Last modified:August 30, 2005 - v1
    Checksum:i9AE804C55A8357D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135435 mRNA. Translation: BAE22531.1.
    AK168082 mRNA. Translation: BAE40055.1.
    AK168591 mRNA. Translation: BAE40460.1.
    CT010273 mRNA. Translation: CAJ18481.1.
    CH466619 Genomic DNA. Translation: EDL02018.1.
    RefSeqiNP_038699.2. NM_013671.3.
    UniGeneiMm.290876.

    Genome annotation databases

    GeneIDi20656.
    KEGGimmu:20656.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135435 mRNA. Translation: BAE22531.1 .
    AK168082 mRNA. Translation: BAE40055.1 .
    AK168591 mRNA. Translation: BAE40460.1 .
    CT010273 mRNA. Translation: CAJ18481.1 .
    CH466619 Genomic DNA. Translation: EDL02018.1 .
    RefSeqi NP_038699.2. NM_013671.3.
    UniGenei Mm.290876.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 20656.
    KEGGi mmu:20656.

    Organism-specific databases

    CTDi 6648.
    MGIi MGI:98352. Sod2.

    Phylogenomic databases

    GeneTreei ENSGT00390000011877.
    HOVERGENi HBG004451.
    InParanoidi Q4FJX9.
    KOi K04564.
    OMAi TERYTAC.

    Miscellaneous databases

    ChiTaRSi SOD2. mouse.
    NextBioi 299085.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q4FJX9.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and DBA/2Imported.
      Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and DBA/2Imported.
      Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and DBA/2Imported.
      Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and DBA/2Imported.
      Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and DBA/2Imported.
      Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
    6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Mullerian duct includes surrounding regionImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and DBA/2Imported.
      Tissue: HeartImported.
    9. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and DBA/2Imported.
      Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
    10. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and DBA/2Imported.
      Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
    11. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ4FJX9_MOUSE
    AccessioniPrimary (citable) accession number: Q4FJX9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 30, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)