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Q4FJX9

- Q4FJX9_MOUSE

UniProt

Q4FJX9 - Q4FJX9_MOUSE

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Protein

Superoxide dismutase

Gene

Sod2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. metal ion binding Source: InterPro
  3. oxygen binding Source: Ensembl
  4. superoxide dismutase activity Source: MGI

GO - Biological processi

  1. age-dependent response to oxidative stress Source: MGI
  2. age-dependent response to reactive oxygen species Source: Ensembl
  3. apoptotic mitochondrial changes Source: MGI
  4. cellular response to ethanol Source: Ensembl
  5. detection of oxygen Source: MGI
  6. erythrophore differentiation Source: MGI
  7. glutathione metabolic process Source: MGI
  8. heart development Source: MGI
  9. hemopoiesis Source: MGI
  10. hydrogen peroxide biosynthetic process Source: Ensembl
  11. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  12. intrinsic apoptotic signaling pathway in response to oxidative stress Source: MGI
  13. iron ion homeostasis Source: MGI
  14. liver development Source: MGI
  15. locomotory behavior Source: MGI
  16. mitochondrion organization Source: MGI
  17. negative regulation of fat cell differentiation Source: MGI
  18. negative regulation of fibroblast proliferation Source: MGI
  19. negative regulation of neuron apoptotic process Source: Ensembl
  20. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
  21. neuron development Source: MGI
  22. oxygen homeostasis Source: Ensembl
  23. positive regulation of nitric oxide biosynthetic process Source: MGI
  24. post-embryonic development Source: MGI
  25. protein homotetramerization Source: Ensembl
  26. regulation of blood pressure Source: MGI
  27. regulation of catalytic activity Source: MGI
  28. regulation of mitochondrial membrane potential Source: MGI
  29. regulation of transcription from RNA polymerase II promoter Source: MGI
  30. release of cytochrome c from mitochondria Source: MGI
  31. removal of superoxide radicals Source: MGI
  32. respiratory electron transport chain Source: MGI
  33. response to activity Source: MGI
  34. response to axon injury Source: MGI
  35. response to cadmium ion Source: Ensembl
  36. response to cold Source: Ensembl
  37. response to drug Source: Ensembl
  38. response to electrical stimulus Source: Ensembl
  39. response to gamma radiation Source: MGI
  40. response to hydrogen peroxide Source: MGI
  41. response to hyperoxia Source: MGI
  42. response to hypoxia Source: Ensembl
  43. response to immobilization stress Source: Ensembl
  44. response to isolation stress Source: Ensembl
  45. response to L-ascorbic acid Source: Ensembl
  46. response to lipopolysaccharide Source: Ensembl
  47. response to magnetism Source: Ensembl
  48. response to manganese ion Source: Ensembl
  49. response to oxidative stress Source: MGI
  50. response to reactive oxygen species Source: MGI
  51. response to selenium ion Source: Ensembl
  52. response to silicon dioxide Source: Ensembl
  53. response to superoxide Source: MGI
  54. response to zinc ion Source: Ensembl
  55. superoxide anion generation Source: MGI
  56. superoxide metabolic process Source: MGI
  57. vasodilation Source: MGI
  58. vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:Sod2Imported
ORF Names:mCG_16695Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98352. Sod2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrial nucleoid Source: Ensembl
  4. mitochondrion Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ4FJX9.

Family & Domainsi

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000011877.
HOVERGENiHBG004451.
KOiK04564.
OMAiTERYTAC.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FJX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLCRAACSTG RRLGPVAGAA GSRHKHSLPD LPYDYGALEP HINAQIMQLH
60 70 80 90 100
HSKHHAAYVN NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI
110 120 130 140 150
FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL
160 170 180 190 200
GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY
210 220
LKAIWNVINW ENVTERYTAC KK
Length:222
Mass (Da):24,603
Last modified:August 30, 2005 - v1
Checksum:i9AE804C55A8357D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135435 mRNA. Translation: BAE22531.1.
AK168082 mRNA. Translation: BAE40055.1.
AK168591 mRNA. Translation: BAE40460.1.
CT010273 mRNA. Translation: CAJ18481.1.
CH466619 Genomic DNA. Translation: EDL02018.1.
RefSeqiNP_038699.2. NM_013671.3.
UniGeneiMm.290876.

Genome annotation databases

GeneIDi20656.
KEGGimmu:20656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135435 mRNA. Translation: BAE22531.1 .
AK168082 mRNA. Translation: BAE40055.1 .
AK168591 mRNA. Translation: BAE40460.1 .
CT010273 mRNA. Translation: CAJ18481.1 .
CH466619 Genomic DNA. Translation: EDL02018.1 .
RefSeqi NP_038699.2. NM_013671.3.
UniGenei Mm.290876.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20656.
KEGGi mmu:20656.

Organism-specific databases

CTDi 6648.
MGIi MGI:98352. Sod2.

Phylogenomic databases

GeneTreei ENSGT00390000011877.
HOVERGENi HBG004451.
KOi K04564.
OMAi TERYTAC.

Miscellaneous databases

ChiTaRSi Sod2. mouse.
NextBioi 299085.
SOURCEi Search...

Gene expression databases

Genevestigatori Q4FJX9.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Mullerian duct includes surrounding regionImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported.
  9. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: HeartImported and Mullerian duct includes surrounding regionImported.
  11. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ4FJX9_MOUSE
AccessioniPrimary (citable) accession number: Q4FJX9
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)