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Protein

Superoxide dismutase

Gene

Sod2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50Divalent metal cationUniRule annotation1
Metal bindingi98Divalent metal cationUniRule annotation1
Metal bindingi183Divalent metal cationUniRule annotation1
Metal bindingi187Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:Sod2Imported
ORF Names:mCG_16695Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98352. Sod2.

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSMUSG00000006818.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 106Sod_Fe_NInterPro annotationAdd BLAST82
Domaini113 – 216Sod_Fe_CInterPro annotationAdd BLAST104

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0876. Eukaryota.
COG0605. LUCA.
HOVERGENiHBG004451.
KOiK04564.
OMAiKWGSFDK.
OrthoDBiEOG091G0MVL.

Family and domain databases

InterProiView protein in InterPro
IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
PfamiView protein in Pfam
PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiView protein in PROSITE
PS00088. SOD_MN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4FJX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCRAACSTG RRLGPVAGAA GSRHKHSLPD LPYDYGALEP HINAQIMQLH
60 70 80 90 100
HSKHHAAYVN NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI
110 120 130 140 150
FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL
160 170 180 190 200
GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY
210 220
LKAIWNVINW ENVTERYTAC KK
Length:222
Mass (Da):24,603
Last modified:August 30, 2005 - v1
Checksum:i9AE804C55A8357D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135435 mRNA. Translation: BAE22531.1.
AK168082 mRNA. Translation: BAE40055.1.
AK168591 mRNA. Translation: BAE40460.1.
CT010273 mRNA. Translation: CAJ18481.1.
CH466619 Genomic DNA. Translation: EDL02018.1.
RefSeqiNP_038699.2. NM_013671.3.
UniGeneiMm.290876.

Genome annotation databases

GeneIDi20656.
KEGGimmu:20656.

Similar proteinsi

Entry informationi

Entry nameiQ4FJX9_MOUSE
AccessioniPrimary (citable) accession number: Q4FJX9
Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: August 30, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)