Q4FJX9 (Q4FJX9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Superoxide dismutase RuleBase RU000414
EC=1.15.1.1 RuleBase RU000414

Gene names

Name:	Sod2 MGI 98352 EMBL EDL02018.1
ORF Names:	mCG_16695 EMBL EDL02018.1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity. RuleBase RU000414
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2. RuleBase RU000414
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family. RuleBase RU004477

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU000414
Gene Ontology (GO)
Biological_process	age-dependent response to oxidative stress Inferred from mutant phenotype PubMed 11226230. Source: MGI age-dependent response to reactive oxygen species Inferred from electronic annotation. Source: Compara cellular response to ethanol Inferred from electronic annotation. Source: Compara detection of oxygen Inferred from mutant phenotype PubMed 11156968. Source: MGI erythrophore differentiation Inferred from mutant phenotype PubMed 15205258. Source: MGI glutathione metabolic process Inferred from mutant phenotype PubMed 10049502. Source: MGI heart development Inferred from mutant phenotype PubMed 7493016. Source: MGI hemopoiesis Inferred from mutant phenotype PubMed 16219542PubMed 8790408. Source: MGI hydrogen peroxide biosynthetic process Inferred from electronic annotation. Source: Compara iron ion homeostasis Inferred from mutant phenotype PubMed 15205258. Source: MGI liver development Inferred from mutant phenotype PubMed 17367743. Source: MGI locomotory behavior Inferred from mutant phenotype PubMed 8790408. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 15642323. Source: MGI negative regulation of fat cell differentiation Inferred from mutant phenotype PubMed 16219542. Source: MGI negative regulation of fibroblast proliferation Inferred from direct assay PubMed 18218638. Source: MGI negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara neuron development Inferred from mutant phenotype PubMed 8790408. Source: MGI oxygen homeostasis Inferred from electronic annotation. Source: Compara positive regulation of nitric oxide biosynthetic process Inferred from mutant phenotype PubMed 15637112. Source: MGI post-embryonic development Inferred from mutant phenotype PubMed 7493016PubMed 8790408. Source: MGI protein homotetramerization Inferred from electronic annotation. Source: Compara regulation of catalytic activity Inferred from mutant phenotype PubMed 9927656. Source: MGI regulation of mitochondrial membrane potential Inferred from mutant phenotype PubMed 17367743. Source: MGI regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 17670746. Source: MGI release of cytochrome c from mitochondria Inferred from mutant phenotype PubMed 10212301PubMed 15642323. Source: MGI removal of superoxide radicals Inferred from mutant phenotype PubMed 16873728. Source: MGI respiratory electron transport chain Inferred from mutant phenotype PubMed 11226230PubMed 19478076. Source: MGI response to L-ascorbic acid Inferred from electronic annotation. Source: Compara response to activity Inferred from mutant phenotype PubMed 15781740. Source: MGI response to axon injury Inferred from mutant phenotype PubMed 16677818. Source: MGI response to cadmium ion Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to electrical stimulus Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from genetic interaction PubMed 15182862. Source: MGI response to hydrogen peroxide Inferred from mutant phenotype PubMed 15642323. Source: MGI response to hyperoxia Inferred from mutant phenotype PubMed 11796207. Source: MGI response to hypoxia Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to manganese ion Inferred from electronic annotation. Source: Compara response to selenium ion Inferred from electronic annotation. Source: Compara response to silicon dioxide Inferred from electronic annotation. Source: Compara response to zinc ion Inferred from electronic annotation. Source: Compara superoxide anion generation Inferred from mutant phenotype PubMed 10212301PubMed 15781740PubMed 16677818. Source: MGI vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure Inferred from mutant phenotype PubMed 16873728. Source: MGI
Cellular_component	mitochondrial inner membrane Inferred from direct assay PubMed 12865426. Source: MGI mitochondrial nucleoid Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from electronic annotation. Source: Compara metal ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: Compara superoxide dismutase activity Inferred from direct assay PubMed 12646716PubMed 18218638PubMed 7333654PubMed 9651187. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4FJX9 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 9AE804C55A8357D9	FASTA	222	24,603
	10 20 30 40 50 60 MLCRAACSTG RRLGPVAGAA GSRHKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 70 80 90 100 110 120 NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI FWTNLSPKGG GEPKGELLEA 130 140 150 160 170 180 IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL 190 200 210 220 GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYTAC KK

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1. Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1. Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1. Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1. Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1. Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[6]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL02018.1.
[7]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22531.1. Tissue: Mullerian duct includes surrounding region EMBL BAE22531.1.
[8]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE40460.1 and DBA/2 EMBL BAE40055.1. Tissue: Heart EMBL BAE40460.1.
[9]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1. Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[10]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22531.1 and DBA/2 EMBL BAE40055.1. Tissue: Heart EMBL BAE40460.1 and Mullerian duct includes surrounding region EMBL BAE22531.1.
[11]	"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)." Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[12]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL02018.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK135435 mRNA. Translation: BAE22531.1. AK168082 mRNA. Translation: BAE40055.1. AK168591 mRNA. Translation: BAE40460.1. CT010273 mRNA. Translation: CAJ18481.1. CH466619 Genomic DNA. Translation: EDL02018.1.
IPI	IPI00109109.
RefSeq	NP_038699.2. NM_013671.3.
UniGene	Mm.290876.
3D structure databases
SMR	Q4FJX9. Positions 25-222.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	20656.
KEGG	mmu:20656.
UCSC	uc008alv.1. mouse.
Organism-specific databases
CTD	6648.
MGI	MGI:98352. Sod2.
Phylogenomic databases
GeneTree	ENSGT00390000011877.
HOVERGEN	HBG004451.
InParanoid	Q4FJX9.
KO	K04564.
OMA	MAPPGKG.
Gene expression databases
Genevestigator	Q4FJX9.
Family and domain databases
InterPro	IPR001189. Mn/Fe_SOD. IPR019833. Mn/Fe_SOD_BS. IPR019832. Mn/Fe_SOD_C. IPR019831. Mn/Fe_SOD_N. [Graphical view]
PANTHER	PTHR11404. PTHR11404. 1 hit.
Pfam	PF02777. Sod_Fe_C. 1 hit. PF00081. Sod_Fe_N. 1 hit. [Graphical view]
PIRSF	PIRSF000349. SODismutase. 1 hit.
PRINTS	PR01703. MNSODISMTASE.
SUPFAM	SSF46609. SODismutase. 1 hit. SSF54719. SODismutase. 1 hit.
PROSITE	PS00088. SOD_MN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SOD2. mouse.
NextBio	299085.
SOURCE	Search...

Entry information

Entry name

Q4FJX9_MOUSE

Accession

Primary (citable) accession number: Q4FJX9

Entry history

Integrated into UniProtKB/TrEMBL:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)