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Protein
Submitted name:

Tgfbr1 protein

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: MGI
  2. I-SMAD binding Source: MGI
  3. protein kinase activity Source: MGI
  4. protein serine/threonine kinase activity Source: MGI
  5. receptor signaling protein activity Source: AgBase
  6. receptor signaling protein serine/threonine kinase activity Source: InterPro
  7. SMAD binding Source: MGI
  8. transforming growth factor beta-activated receptor activity Source: MGI
  9. transforming growth factor beta binding Source: MGI
  10. transforming growth factor beta receptor activity, type I Source: AgBase
  11. type II transforming growth factor beta receptor binding Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: MGI
  2. activin receptor signaling pathway Source: AgBase
  3. angiogenesis Source: MGI
  4. anterior/posterior pattern specification Source: MGI
  5. artery morphogenesis Source: MGI
  6. blastocyst development Source: MGI
  7. cardiac epithelial to mesenchymal transition Source: AgBase
  8. cell motility Source: MGI
  9. cellular response to transforming growth factor beta stimulus Source: MGI
  10. collagen fibril organization Source: MGI
  11. embryonic cranial skeleton morphogenesis Source: MGI
  12. endothelial cell activation Source: AgBase
  13. endothelial cell migration Source: MGI
  14. epithelial to mesenchymal transition Source: MGI
  15. germ cell migration Source: MGI
  16. heart development Source: AgBase
  17. intracellular signal transduction Source: AgBase
  18. in utero embryonic development Source: MGI
  19. kidney development Source: MGI
  20. lens development in camera-type eye Source: MGI
  21. male gonad development Source: MGI
  22. mesenchymal cell differentiation Source: AgBase
  23. negative regulation of apoptotic process Source: MGI
  24. negative regulation of endothelial cell proliferation Source: MGI
  25. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  26. neuron fate commitment Source: MGI
  27. palate development Source: MGI
  28. parathyroid gland development Source: MGI
  29. pathway-restricted SMAD protein phosphorylation Source: MGI
  30. peptidyl-serine phosphorylation Source: MGI
  31. peptidyl-threonine phosphorylation Source: MGI
  32. pharyngeal system development Source: MGI
  33. positive regulation of apoptotic signaling pathway Source: MGI
  34. positive regulation of cell growth Source: MGI
  35. positive regulation of cell proliferation Source: MGI
  36. positive regulation of cellular component movement Source: MGI
  37. positive regulation of endothelial cell proliferation Source: AgBase
  38. positive regulation of filopodium assembly Source: MGI
  39. positive regulation of gene expression Source: AgBase
  40. positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  41. positive regulation of protein kinase B signaling Source: MGI
  42. positive regulation of SMAD protein import into nucleus Source: MGI
  43. positive regulation of transcription, DNA-templated Source: AgBase
  44. post-embryonic development Source: MGI
  45. protein phosphorylation Source: MGI
  46. regulation of epithelial to mesenchymal transition Source: AgBase
  47. regulation of gene expression Source: AgBase
  48. regulation of protein binding Source: MGI
  49. regulation of protein ubiquitination Source: MGI
  50. regulation of transcription, DNA-templated Source: MGI
  51. response to cholesterol Source: MGI
  52. signal transduction Source: MGI
  53. skeletal system development Source: MGI
  54. skeletal system morphogenesis Source: MGI
  55. thymus development Source: MGI
  56. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tgfbr1 proteinImported
Submitted name:
Transforming growth factor, beta receptor IImported
Gene namesi
Name:Tgfbr1Imported
ORF Names:mCG_7380Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: MGI
  2. cell Source: AgBase
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: AgBase
  5. membrane raft Source: MGI
  6. plasma membrane Source: MGI
  7. receptor complex Source: MGI
  8. tight junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ4FJL1.

Expressioni

Gene expression databases

BgeeiQ4FJL1.
ExpressionAtlasiQ4FJL1. baseline and differential.
GenevestigatoriQ4FJL1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007757.

Structurei

3D structure databases

ProteinModelPortaliQ4FJL1.
SMRiQ4FJL1. Positions 27-110, 175-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG054502.
KOiK04674.
OMAiLYICHNR.
PhylomeDBiQ4FJL1.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FJL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAAAAPRR PQLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC
60 70 80 90 100
FVSVTETTDK VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTTTYCCNQD
110 120 130 140 150
HCNKIELPTT GPFSEKQSAG LGPVELAAVI AGPVCFVCIA LMLMVYICHN
160 170 180 190 200
RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT
210 220 230 240 250
IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ
260 270 280 290 300
TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE
310 320 330 340 350
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA
360 370 380 390 400
DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD
410 420 430 440 450
IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL
460 470 480 490 500
RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG

IKM
Length:503
Mass (Da):56,179
Last modified:August 29, 2005 - v1
Checksum:iBB8BB6D2261793AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010393 mRNA. Translation: CAJ18600.1.
CH466565 Genomic DNA. Translation: EDL02353.1.
RefSeqiNP_033396.1. NM_009370.2.
UniGeneiMm.197552.

Genome annotation databases

GeneIDi21812.
KEGGimmu:21812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010393 mRNA. Translation: CAJ18600.1.
CH466565 Genomic DNA. Translation: EDL02353.1.
RefSeqiNP_033396.1. NM_009370.2.
UniGeneiMm.197552.

3D structure databases

ProteinModelPortaliQ4FJL1.
SMRiQ4FJL1. Positions 27-110, 175-500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007757.

Chemistry

BindingDBiQ4FJL1.

Proteomic databases

PRIDEiQ4FJL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21812.
KEGGimmu:21812.

Organism-specific databases

CTDi7046.
MGIiMGI:98728. Tgfbr1.

Phylogenomic databases

HOVERGENiHBG054502.
KOiK04674.
OMAiLYICHNR.
PhylomeDBiQ4FJL1.

Miscellaneous databases

ChiTaRSiTgfbr1. mouse.
NextBioi301202.
SOURCEiSearch...

Gene expression databases

BgeeiQ4FJL1.
ExpressionAtlasiQ4FJL1. baseline and differential.
GenevestigatoriQ4FJL1.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ4FJL1_MOUSE
AccessioniPrimary (citable) accession number: Q4FJL1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 29, 2005
Last sequence update: August 29, 2005
Last modified: March 31, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.