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Q4FJL1

- Q4FJL1_MOUSE

UniProt

Q4FJL1 - Q4FJL1_MOUSE

Protein
Submitted name:

Tgfbr1 protein

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. transforming growth factor beta-activated receptor activity Source: MGI
    5. transforming growth factor beta binding Source: MGI
    6. transforming growth factor beta receptor activity, type I Source: Ensembl

    GO - Biological processi

    1. activation of MAPKK activity Source: Ensembl
    2. angiogenesis Source: MGI
    3. anterior/posterior pattern specification Source: MGI
    4. artery morphogenesis Source: MGI
    5. blastocyst development Source: MGI
    6. collagen fibril organization Source: MGI
    7. embryonic cranial skeleton morphogenesis Source: MGI
    8. endothelial cell migration Source: MGI
    9. epithelial to mesenchymal transition Source: Ensembl
    10. germ cell migration Source: MGI
    11. heart development Source: MGI
    12. in utero embryonic development Source: MGI
    13. kidney development Source: MGI
    14. lens development in camera-type eye Source: MGI
    15. negative regulation of apoptotic process Source: MGI
    16. negative regulation of endothelial cell proliferation Source: MGI
    17. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    18. neuron fate commitment Source: MGI
    19. palate development Source: MGI
    20. parathyroid gland development Source: MGI
    21. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    22. peptidyl-serine phosphorylation Source: Ensembl
    23. peptidyl-threonine phosphorylation Source: Ensembl
    24. pharyngeal system development Source: MGI
    25. positive regulation of apoptotic signaling pathway Source: Ensembl
    26. positive regulation of cell growth Source: Ensembl
    27. positive regulation of cell proliferation Source: Ensembl
    28. positive regulation of cellular component movement Source: Ensembl
    29. positive regulation of filopodium assembly Source: MGI
    30. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    31. positive regulation of protein kinase B signaling Source: Ensembl
    32. positive regulation of SMAD protein import into nucleus Source: Ensembl
    33. positive regulation of transcription, DNA-templated Source: Ensembl
    34. post-embryonic development Source: MGI
    35. regulation of gene expression Source: MGI
    36. regulation of protein binding Source: MGI
    37. regulation of protein ubiquitination Source: Ensembl
    38. skeletal system development Source: MGI
    39. skeletal system morphogenesis Source: MGI
    40. thymus development Source: MGI
    41. transforming growth factor beta receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tgfbr1 proteinImported
    Submitted name:
    Transforming growth factor, beta receptor IImported
    Gene namesi
    Name:Tgfbr1Imported
    ORF Names:mCG_7380Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:98728. Tgfbr1.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: MGI
    4. receptor complex Source: Ensembl
    5. tight junction Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ4FJL1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000007757.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG054502.
    InParanoidiQ4FJL1.
    KOiK04674.
    OMAiLYICHNR.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4FJL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAAAAAPRR PQLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC    50
    FVSVTETTDK VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTTTYCCNQD 100
    HCNKIELPTT GPFSEKQSAG LGPVELAAVI AGPVCFVCIA LMLMVYICHN 150
    RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT 200
    IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ 250
    TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 300
    GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA 350
    DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD 400
    IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL 450
    RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG 500
    IKM 503
    Length:503
    Mass (Da):56,179
    Last modified:August 30, 2005 - v1
    Checksum:iBB8BB6D2261793AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010393 mRNA. Translation: CAJ18600.1.
    CH466565 Genomic DNA. Translation: EDL02353.1.
    RefSeqiNP_033396.1. NM_009370.2.
    UniGeneiMm.197552.

    Genome annotation databases

    GeneIDi21812.
    KEGGimmu:21812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010393 mRNA. Translation: CAJ18600.1 .
    CH466565 Genomic DNA. Translation: EDL02353.1 .
    RefSeqi NP_033396.1. NM_009370.2.
    UniGenei Mm.197552.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000007757.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 21812.
    KEGGi mmu:21812.

    Organism-specific databases

    CTDi 7046.
    MGIi MGI:98728. Tgfbr1.

    Phylogenomic databases

    HOVERGENi HBG054502.
    InParanoidi Q4FJL1.
    KOi K04674.
    OMAi LYICHNR.

    Miscellaneous databases

    ChiTaRSi TGFBR1. mouse.
    NextBioi 301202.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q4FJL1.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ4FJL1_MOUSE
    AccessioniPrimary (citable) accession number: Q4FJL1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 30, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)