Q4FJL1 (Q4FJL1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Tgfbr1 protein EMBL CAJ18600.1

Submitted name:
Transforming growth factor, beta receptor I EMBL EDL02353.1

Gene names

Name:	Tgfbr1 EMBL EDL02353.1 MGI 98728
ORF Names:	mCG_7380 EMBL EDL02353.1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Receptor EMBL EDL02353.1 Serine/threonine-protein kinase RuleBase RU000305 Transferase
Gene Ontology (GO)
Biological_process	activation of MAPKK activity Inferred from electronic annotation. Source: Compara angiogenesis Inferred from mutant phenotype PubMed 11285230. Source: MGI anterior/posterior pattern specification Inferred from genetic interaction PubMed 16845371. Source: MGI artery morphogenesis Inferred from mutant phenotype PubMed 17078885. Source: MGI blastocyst development Inferred from direct assay PubMed 9921650. Source: MGI collagen fibril organization Inferred from mutant phenotype PubMed 15993878. Source: MGI embryonic cranial skeleton morphogenesis Inferred from mutant phenotype PubMed 16806156. Source: MGI endothelial cell migration Inferred from mutant phenotype PubMed 11285230. Source: MGI epithelial to mesenchymal transition Inferred from electronic annotation. Source: Compara germ cell migration Inferred from mutant phenotype PubMed 15993878. Source: MGI heart development Inferred from mutant phenotype PubMed 17078885. Source: MGI induction of apoptosis Inferred from mutant phenotype PubMed 16806156. Source: MGI kidney development Inferred from genetic interaction PubMed 16845371. Source: MGI lens development in camera-type eye Inferred from mutant phenotype PubMed 11641223. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 17078885. Source: MGI negative regulation of endothelial cell proliferation Inferred from genetic interaction PubMed 21832243. Source: MGI neuron fate commitment Inferred from mutant phenotype PubMed 15744664. Source: MGI palate development Inferred from mutant phenotype PubMed 16806156. Source: MGI parathyroid gland development Inferred from mutant phenotype PubMed 17078885. Source: MGI pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara pharyngeal system development Inferred from mutant phenotype PubMed 17078885. Source: MGI positive regulation of SMAD protein import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cellular component movement Inferred from electronic annotation. Source: Compara positive regulation of filopodium assembly Inferred from mutant phenotype PubMed 16806156. Source: MGI positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara post-embryonic development Inferred from mutant phenotype PubMed 16806156. Source: MGI regulation of gene expression Inferred from mutant phenotype PubMed 16806156. Source: MGI regulation of protein binding Inferred from mutant phenotype PubMed 16601693. Source: MGI regulation of protein ubiquitination Inferred from electronic annotation. Source: Compara response to cholesterol Inferred from electronic annotation. Source: Compara thymus development Inferred from mutant phenotype PubMed 17078885. Source: MGI transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 14580334PubMed 15820682. Source: MGI
Cellular_component	caveola Inferred from sequence orthology PubMed 17878231. Source: MGI receptor complex Inferred from electronic annotation. Source: Compara tight junction Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta-activated receptor activity Inferred from direct assay PubMed 15820682. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4FJL1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: BB8BB6D2261793AF	FASTA	503	56,179
	10 20 30 40 50 60 MEAAAAAPRR PQLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC FVSVTETTDK 70 80 90 100 110 120 VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTTTYCCNQD HCNKIELPTT GPFSEKQSAG 130 140 150 160 170 180 LGPVELAAVI AGPVCFVCIA LMLMVYICHN RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL 190 200 210 220 230 240 IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 250 260 270 280 290 300 SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 310 320 330 340 350 360 GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS 370 380 390 400 410 420 ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI 430 440 450 460 470 480 HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA 490 500 ARLTALRIKK TLSQLSQQEG IKM

References

[1]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL02353.1.
[2]	"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)." Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL02353.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT010393 mRNA. Translation: CAJ18600.1. CH466565 Genomic DNA. Translation: EDL02353.1.
IPI	IPI00137994.
RefSeq	NP_033396.1. NM_009370.2.
UniGene	Mm.197552.
3D structure databases
SMR	Q4FJL1. Positions 27-110, 175-500.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000007757.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	21812.
KEGG	mmu:21812.
UCSC	uc008sun.1. mouse.
Organism-specific databases
CTD	7046.
MGI	MGI:98728. Tgfbr1.
Phylogenomic databases
HOVERGEN	HBG054502.
InParanoid	Q4FJL1.
KO	K04674.
OMA	CISLMLI.
Gene expression databases
Genevestigator	Q4FJL1.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
SMART	SM00467. GS. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TGFBR1. mouse.
NextBio	301202.
SOURCE	Search...

Entry information

Entry name

Q4FJL1_MOUSE

Accession

Primary (citable) accession number: Q4FJL1

Entry history

Integrated into UniProtKB/TrEMBL:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)