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Q4FJL1

- Q4FJL1_MOUSE

UniProt

Q4FJL1 - Q4FJL1_MOUSE

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Protein
Submitted name: Tgfbr1 protein
Gene
Tgfbr1, mCG_7380
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: MGI
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transforming growth factor beta binding Source: MGI
  5. transforming growth factor beta receptor activity, type I Source: Ensembl
  6. transforming growth factor beta-activated receptor activity Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: Ensembl
  2. angiogenesis Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. artery morphogenesis Source: MGI
  5. blastocyst development Source: MGI
  6. collagen fibril organization Source: MGI
  7. embryonic cranial skeleton morphogenesis Source: MGI
  8. endothelial cell migration Source: MGI
  9. epithelial to mesenchymal transition Source: Ensembl
  10. germ cell migration Source: MGI
  11. heart development Source: MGI
  12. in utero embryonic development Source: MGI
  13. kidney development Source: MGI
  14. lens development in camera-type eye Source: MGI
  15. negative regulation of apoptotic process Source: MGI
  16. negative regulation of endothelial cell proliferation Source: MGI
  17. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  18. neuron fate commitment Source: MGI
  19. palate development Source: MGI
  20. parathyroid gland development Source: MGI
  21. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  22. peptidyl-serine phosphorylation Source: Ensembl
  23. peptidyl-threonine phosphorylation Source: Ensembl
  24. pharyngeal system development Source: MGI
  25. positive regulation of SMAD protein import into nucleus Source: Ensembl
  26. positive regulation of apoptotic signaling pathway Source: Ensembl
  27. positive regulation of cell growth Source: Ensembl
  28. positive regulation of cell proliferation Source: Ensembl
  29. positive regulation of cellular component movement Source: Ensembl
  30. positive regulation of filopodium assembly Source: MGI
  31. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  32. positive regulation of protein kinase B signaling Source: Ensembl
  33. positive regulation of transcription, DNA-templated Source: Ensembl
  34. post-embryonic development Source: MGI
  35. regulation of gene expression Source: MGI
  36. regulation of protein binding Source: MGI
  37. regulation of protein ubiquitination Source: Ensembl
  38. skeletal system development Source: MGI
  39. skeletal system morphogenesis Source: MGI
  40. thymus development Source: MGI
  41. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationsImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tgfbr1 proteinImported
Submitted name:
Transforming growth factor, beta receptor IImported
Gene namesi
Name:Tgfbr1Imported
ORF Names:mCG_7380Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: MGI
  4. receptor complex Source: Ensembl
  5. tight junction Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ4FJL1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007757.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG054502.
InParanoidiQ4FJL1.
KOiK04674.
OMAiLYICHNR.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FJL1-1 [UniParc]FASTAAdd to Basket

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MEAAAAAPRR PQLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC    50
FVSVTETTDK VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTTTYCCNQD 100
HCNKIELPTT GPFSEKQSAG LGPVELAAVI AGPVCFVCIA LMLMVYICHN 150
RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT 200
IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ 250
TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 300
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA 350
DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD 400
IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL 450
RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG 500
IKM 503
Length:503
Mass (Da):56,179
Last modified:August 30, 2005 - v1
Checksum:iBB8BB6D2261793AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT010393 mRNA. Translation: CAJ18600.1.
CH466565 Genomic DNA. Translation: EDL02353.1.
RefSeqiNP_033396.1. NM_009370.2.
UniGeneiMm.197552.

Genome annotation databases

GeneIDi21812.
KEGGimmu:21812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT010393 mRNA. Translation: CAJ18600.1 .
CH466565 Genomic DNA. Translation: EDL02353.1 .
RefSeqi NP_033396.1. NM_009370.2.
UniGenei Mm.197552.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000007757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 21812.
KEGGi mmu:21812.

Organism-specific databases

CTDi 7046.
MGIi MGI:98728. Tgfbr1.

Phylogenomic databases

HOVERGENi HBG054502.
InParanoidi Q4FJL1.
KOi K04674.
OMAi LYICHNR.

Miscellaneous databases

ChiTaRSi TGFBR1. mouse.
NextBioi 301202.
SOURCEi Search...

Gene expression databases

Genevestigatori Q4FJL1.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ4FJL1_MOUSE
AccessioniPrimary (citable) accession number: Q4FJL1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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