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Protein

NAD-dependent protein deacetylase

Gene

Sirt3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

NAD-dependent protein deacetylase.UniRule annotation

Catalytic activityi

NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.UniRule annotation

Cofactori

Zn2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106Proton acceptorUniRule annotation1
Metal bindingi114ZincUniRule annotation1
Metal bindingi117ZincUniRule annotation1
Metal bindingi138ZincUniRule annotation1
Metal bindingi141ZincUniRule annotation1
Binding sitei224NAD; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 23NADUniRule annotationAdd BLAST21
Nucleotide bindingi86 – 89NADUniRule annotation4
Nucleotide bindingi177 – 179NADUniRule annotation3
Nucleotide bindingi202 – 204NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMetal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent protein deacetylaseUniRule annotation (EC:3.5.1.-UniRule annotation)
Gene namesi
Name:Sirt3Imported
ORF Names:mCG_22591Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1927665 Sirt3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000025486

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 240Deacetylase sirtuin-typeInterPro annotationAdd BLAST240

Sequence similaritiesi

Belongs to the sirtuin family. Class I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2682 Eukaryota
COG0846 LUCA
HOVERGENiHBG057095

Family and domain databases

Gene3Di3.30.1600.10, 2 hits
InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR003000 Sirtuin
IPR026591 Sirtuin_cat_small_dom_sf
IPR017328 Sirtuin_class_I
IPR026590 Ssirtuin_cat_dom
PfamiView protein in Pfam
PF02146 SIR2, 1 hit
PIRSFiPIRSF037938 SIR2_euk, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS50305 SIRTUIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q4FJK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGAGISTPS GIPDFRSPGS GLYSNLQQYD IPYPEAIFEL GFFFHNPKPF
60 70 80 90 100
FMLAKELYPG HYRPNVTHYF LRLLHDKELL LRLYTQNIDG LERASGIPAS
110 120 130 140 150
KLVEAHGTFV TATCTVCRRS FPGEDIWADV MADRVPRCPV CTGVVKPDIV
160 170 180 190 200
FFGEQLPARF LLHMADFALA DLLLILGTSL EVEPFASLSE AVQKSVPRLL
210 220 230 240 250
INRDLVGPFV LSPRRKDVVQ LGDVVHGVER LVDLLGWTQE LLDLMQRERG

KLDGQDR
Length:257
Mass (Da):28,822
Last modified:August 30, 2005 - v1
Checksum:iF756041FBC9B985E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010402 mRNA Translation: CAJ18608.1
CH466531 Genomic DNA Translation: EDL17961.1
CH466531 Genomic DNA Translation: EDL17963.1
RefSeqiNP_001120823.1, NM_001127351.1
NP_071878.2, NM_022433.2
UniGeneiMm.244216
Mm.29760

Genome annotation databases

GeneIDi64384

Similar proteinsi

Entry informationi

Entry nameiQ4FJK3_MOUSE
AccessioniPrimary (citable) accession number: Q4FJK3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health