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Protein
Submitted name:

Sirt3 protein

Gene

Sirt3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. NAD+ binding Source: InterPro
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: MGI
  3. zinc ion binding Source: MGI

GO - Biological processi

  1. aerobic respiration Source: MGI
  2. aging Source: Ensembl
  3. histone H3 deacetylation Source: GOC
  4. negative regulation of peptidyl-lysine acetylation Source: MGI
  5. peptidyl-lysine deacetylation Source: MGI
  6. protein deacetylation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Sirt3 proteinImported
Submitted name:
Sirtuin 3 (Silent mating type information regulation 2, homolog) 3 (S. cerevisiae), isoform CRA_aImported
Gene namesi
Name:Sirt3Imported
ORF Names:mCG_22591Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1927665. Sirt3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. membrane Source: MGI
  3. mitochondrial matrix Source: MGI
  4. mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ4FJK3.

Expressioni

Gene expression databases

BgeeiQ4FJK3.
ExpressionAtlasiQ4FJK3. baseline and differential.
GenevestigatoriQ4FJK3.

Structurei

3D structure databases

ProteinModelPortaliQ4FJK3.
SMRiQ4FJK3. Positions 1-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG057095.
KOiK11413.
OMAiWETHMEC.

Family and domain databases

Gene3Di3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR017328. Sirtuin_class_I.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
PIRSFiPIRSF037938. SIR2_euk. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4FJK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGAGISTPS GIPDFRSPGS GLYSNLQQYD IPYPEAIFEL GFFFHNPKPF
60 70 80 90 100
FMLAKELYPG HYRPNVTHYF LRLLHDKELL LRLYTQNIDG LERASGIPAS
110 120 130 140 150
KLVEAHGTFV TATCTVCRRS FPGEDIWADV MADRVPRCPV CTGVVKPDIV
160 170 180 190 200
FFGEQLPARF LLHMADFALA DLLLILGTSL EVEPFASLSE AVQKSVPRLL
210 220 230 240 250
INRDLVGPFV LSPRRKDVVQ LGDVVHGVER LVDLLGWTQE LLDLMQRERG

KLDGQDR
Length:257
Mass (Da):28,822
Last modified:August 29, 2005 - v1
Checksum:iF756041FBC9B985E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010402 mRNA. Translation: CAJ18608.1.
CH466531 Genomic DNA. Translation: EDL17961.1.
CH466531 Genomic DNA. Translation: EDL17963.1.
RefSeqiNP_001120823.1. NM_001127351.1.
NP_071878.2. NM_022433.2.
UniGeneiMm.244216.

Genome annotation databases

GeneIDi64384.
KEGGimmu:64384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010402 mRNA. Translation: CAJ18608.1.
CH466531 Genomic DNA. Translation: EDL17961.1.
CH466531 Genomic DNA. Translation: EDL17963.1.
RefSeqiNP_001120823.1. NM_001127351.1.
NP_071878.2. NM_022433.2.
UniGeneiMm.244216.

3D structure databases

ProteinModelPortaliQ4FJK3.
SMRiQ4FJK3. Positions 1-248.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ4FJK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64384.
KEGGimmu:64384.

Organism-specific databases

CTDi23410.
MGIiMGI:1927665. Sirt3.

Phylogenomic databases

HOVERGENiHBG057095.
KOiK11413.
OMAiWETHMEC.

Miscellaneous databases

ChiTaRSiSirt3. mouse.
NextBioi320063.
SOURCEiSearch...

Gene expression databases

BgeeiQ4FJK3.
ExpressionAtlasiQ4FJK3. baseline and differential.
GenevestigatoriQ4FJK3.

Family and domain databases

Gene3Di3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR017328. Sirtuin_class_I.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
PIRSFiPIRSF037938. SIR2_euk. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ4FJK3_MOUSE
AccessioniPrimary (citable) accession number: Q4FJK3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 29, 2005
Last sequence update: August 29, 2005
Last modified: March 31, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.