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Q4FCZ5 (SSN3_GIBMO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8, FCK1
OrganismGibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium verticillioides)
Taxonomic identifier117187 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium fujikuroi species complex

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity. Required for normal growth and secondary metabolism. Ref.1

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity. Interacts with SSN8/FCC1. Ref.1

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Serine/threonine-protein kinase SSN3
PRO_0000312945

Regions

Domain40 – 393354Protein kinase
Nucleotide binding46 – 549ATP By similarity
Compositional bias310 – 32516His-rich

Sites

Active site1731Proton acceptor By similarity
Binding site711ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4FCZ5 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 0DDBF7B8C07F2334

FASTA45050,892
        10         20         30         40         50         60 
MPLRPHIGLG FPAHAYQKRH VEPHDRSTGY QPKVRITDRY RIIGFISSGT YGRVYKAVGR 

        70         80         90        100        110        120 
NGKPVGEFAI KKFKPDKEGE QISYTGISQS AIREMSLCSE LHHINVIRLC EIVLEDKCIF 

       130        140        150        160        170        180 
MVFEYAEHDL LQIIHHHTQQ PRHPIPPATI KSIMFQLLNG CQYLHINWVL HRDLKPANIM 

       190        200        210        220        230        240 
VTSSGEVKIG DLGLARRFDK PLHSLFSGDK VVVTIWYRAP ELILGSYHYT PAIDMWAVGC 

       250        260        270        280        290        300 
IFAELLSLRP IFKGEEAKMD SKKTVPFRRN QMQKIIEIMG VPTKDKWPLL STMPEYNQLN 

       310        320        330        340        350        360 
TLANSMASSH HNHHSHHHPH HHHGHYGSRN PPPPGGSNLE KWYYSTINHT SAPGGTPPLA 

       370        380        390        400        410        420 
SLGSEGYKLL AGLLEYDPSK RLTAAQALQS PFFSTGDRVS ANCFEGCKNE YPCRRVSQDD 

       430        440        450 
NDIRTSSLPG TKRSGLPDDS LIRPAKRQKE 

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References

[1]"Fck1, a C-type cyclin-dependent kinase, interacts with Fcc1 to regulate development and secondary metabolism in Fusarium verticillioides."
Bluhm B.H., Woloshuk C.P.
Fungal Genet. Biol. 43:146-154(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH SSN8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ091181 Genomic DNA. Translation: AAY99646.1.

3D structure databases

ProteinModelPortalQ4FCZ5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_GIBMO
AccessionPrimary (citable) accession number: Q4FCZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families