Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4FAT7

- BGLR_PIG

UniProt

Q4FAT7 - BGLR_PIG

Protein

Beta-glucuronidase

Gene

GUSB

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays an important role in the degradation of dermatan and keratan sulfates.By similarity

    Catalytic activityi

    A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.

    Enzyme regulationi

    Inhibited by L-aspartic acid.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei451 – 4511Proton donorBy similarity

    GO - Molecular functioni

    1. beta-glucuronidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_203030. HS-GAG degradation.
    REACT_221087. Hyaluronan uptake and degradation.

    Protein family/group databases

    CAZyiGH2. Glycoside Hydrolase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-glucuronidase (EC:3.2.1.31)
    Gene namesi
    Name:GUSB
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 3

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 652630Beta-glucuronidasePRO_0000231599Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi631 – 6311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ4FAT7.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000008265.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4FAT7.
    SMRiQ4FAT7. Positions 24-632.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3250.
    GeneTreeiENSGT00390000001752.
    HOGENOMiHOG000120896.
    HOVERGENiHBG004843.
    KOiK01195.
    OMAiNAHLWWP.
    OrthoDBiEOG7288QR.
    TreeFamiTF300685.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SUPFAMiSSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4FAT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRGPAGAWA VLGPLLWGCG LALLQGGMLY PQESRSRERK ELNGLWSFRA    50
    DFSDNRRQGF EQQWYRKPLR ESGPTLDMPV PSSFNDISQD GRLRSFIGWV 100
    WYEREAILPQ RWTQDLGTRV VLRISSAHYY AIVWVNGVHV TEHEGGHLPF 150
    EADISKLVQT GPLSSCRITI AINNTLSPHT LPPGTILYKT DTSKYPKGYF 200
    VQNTNFDFFN YAGLHRPVLL YTTPTAYIDD ITVTTDVDQD TGLVNYQIFV 250
    QGSDHFQLEV HLLDEEGRVV AKGTGGQGQL QVPSAHLWWP YLMHERPAYL 300
    YSLEVKLTAQ TSAGPLSDFY TLPVGIRTVA VTERQFLING KPFYFHGVNK 350
    HEDADIRGKG FDWSLLVKDF NLLRWLGANA FRTSHYPYAE EVMQLCDRYG 400
    IVVIDESPGV GIVLAQSFSN ASLQHHLEVM EEMVRRDKNH PAVVMWSVAN 450
    EPSSFLEQAA YYFKMLIGHT KALDPSRPVT FVTSSSYEKD LGVPYVDVIC 500
    VNSYYSWYHD YGHMEVIQLQ LATQFERWHE AYQKPIIQSE YGAETIIGFH 550
    EDPPLMFSEE YQKGLLQQYH VILDQKRKEY VVGELIWNFA DFMTDQSPQR 600
    AIGNRKGIFT RQRQPKSAAF LLRERYWKLA NETRYLQSAV MSQCVGNSPF 650
    TV 652
    Length:652
    Mass (Da):74,710
    Last modified:August 30, 2005 - v1
    Checksum:i7B9386564DFF2CA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ095863 Genomic DNA. Translation: AAZ03639.1.
    RefSeqiNP_001116593.1. NM_001123121.1.
    UniGeneiSsc.18585.

    Genome annotation databases

    EnsembliENSSSCT00000008484; ENSSSCP00000008265; ENSSSCG00000007739.
    GeneIDi100144519.
    KEGGissc:100144519.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ095863 Genomic DNA. Translation: AAZ03639.1 .
    RefSeqi NP_001116593.1. NM_001123121.1.
    UniGenei Ssc.18585.

    3D structure databases

    ProteinModelPortali Q4FAT7.
    SMRi Q4FAT7. Positions 24-632.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000008265.

    Protein family/group databases

    CAZyi GH2. Glycoside Hydrolase Family 2.

    Proteomic databases

    PaxDbi Q4FAT7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000008484 ; ENSSSCP00000008265 ; ENSSSCG00000007739 .
    GeneIDi 100144519.
    KEGGi ssc:100144519.

    Organism-specific databases

    CTDi 2990.

    Phylogenomic databases

    eggNOGi COG3250.
    GeneTreei ENSGT00390000001752.
    HOGENOMi HOG000120896.
    HOVERGENi HBG004843.
    KOi K01195.
    OMAi NAHLWWP.
    OrthoDBi EOG7288QR.
    TreeFami TF300685.

    Enzyme and pathway databases

    Reactomei REACT_203030. HS-GAG degradation.
    REACT_221087. Hyaluronan uptake and degradation.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SUPFAMi SSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Beck J., Knorr C., Brenig B.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiBGLR_PIG
    AccessioniPrimary (citable) accession number: Q4FAT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3