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Q4FAT7 (BGLR_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-glucuronidase

EC=3.2.1.31
Gene names
Name:GUSB
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length652 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in the degradation of dermatan and keratan sulfates By similarity.

Catalytic activity

A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.

Enzyme regulation

Inhibited by L-aspartic acid By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 2 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-glucuronidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 652630Beta-glucuronidase
PRO_0000231599

Sites

Active site4511Proton donor By similarity

Amino acid modifications

Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation4201N-linked (GlcNAc...) Potential
Glycosylation6311N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q4FAT7 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: 7B9386564DFF2CA7

FASTA65274,710
        10         20         30         40         50         60 
MVRGPAGAWA VLGPLLWGCG LALLQGGMLY PQESRSRERK ELNGLWSFRA DFSDNRRQGF 

        70         80         90        100        110        120 
EQQWYRKPLR ESGPTLDMPV PSSFNDISQD GRLRSFIGWV WYEREAILPQ RWTQDLGTRV 

       130        140        150        160        170        180 
VLRISSAHYY AIVWVNGVHV TEHEGGHLPF EADISKLVQT GPLSSCRITI AINNTLSPHT 

       190        200        210        220        230        240 
LPPGTILYKT DTSKYPKGYF VQNTNFDFFN YAGLHRPVLL YTTPTAYIDD ITVTTDVDQD 

       250        260        270        280        290        300 
TGLVNYQIFV QGSDHFQLEV HLLDEEGRVV AKGTGGQGQL QVPSAHLWWP YLMHERPAYL 

       310        320        330        340        350        360 
YSLEVKLTAQ TSAGPLSDFY TLPVGIRTVA VTERQFLING KPFYFHGVNK HEDADIRGKG 

       370        380        390        400        410        420 
FDWSLLVKDF NLLRWLGANA FRTSHYPYAE EVMQLCDRYG IVVIDESPGV GIVLAQSFSN 

       430        440        450        460        470        480 
ASLQHHLEVM EEMVRRDKNH PAVVMWSVAN EPSSFLEQAA YYFKMLIGHT KALDPSRPVT 

       490        500        510        520        530        540 
FVTSSSYEKD LGVPYVDVIC VNSYYSWYHD YGHMEVIQLQ LATQFERWHE AYQKPIIQSE 

       550        560        570        580        590        600 
YGAETIIGFH EDPPLMFSEE YQKGLLQQYH VILDQKRKEY VVGELIWNFA DFMTDQSPQR 

       610        620        630        640        650 
AIGNRKGIFT RQRQPKSAAF LLRERYWKLA NETRYLQSAV MSQCVGNSPF TV 

« Hide

References

[1]Beck J., Knorr C., Brenig B.
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ095863 Genomic DNA. Translation: AAZ03639.1.
RefSeqNP_001116593.1. NM_001123121.1.
UniGeneSsc.18585.

3D structure databases

ProteinModelPortalQ4FAT7.
SMRQ4FAT7. Positions 24-632.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000008265.

Protein family/group databases

CAZyGH2. Glycoside Hydrolase Family 2.

Proteomic databases

PaxDbQ4FAT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000008484; ENSSSCP00000008265; ENSSSCG00000007739.
GeneID100144519.
KEGGssc:100144519.

Organism-specific databases

CTD2990.

Phylogenomic databases

eggNOGCOG3250.
GeneTreeENSGT00390000001752.
HOGENOMHOG000120896.
HOVERGENHBG004843.
KOK01195.
OMAYGHMEVI.
OrthoDBEOG7288QR.
TreeFamTF300685.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProIPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSPR00132. GLHYDRLASE2.
SUPFAMSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGLR_PIG
AccessionPrimary (citable) accession number: Q4FAT7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 30, 2005
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries