Reviewed, UniProtKB/Swiss-Prot Q4FAT7 (BGLR_PIG)

Names and origin

Protein names

Recommended name:
    Beta-glucuronidase
    EC=3.2.1.31

Gene names

Name:

GUSB

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	652 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Plays an important role in the degradation of dermatan and keratan sulfates By similarity.
Catalytic activity	A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.
Enzyme regulation	Inhibited by L-aspartic acid By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 2 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-glucuronidase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity
	Chain	23 – 652	630	Beta-glucuronidase		PRO_0000231599
Sites
	Active site	451	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	173	1	N-linked (GlcNAc...) Potential
	Glycosylation	420	1	N-linked (GlcNAc...) Potential
	Glycosylation	631	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4FAT7-1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 7B9386564DFF2CA7	FASTA	652	74,710
	10 20 30 40 50 60 MVRGPAGAWA VLGPLLWGCG LALLQGGMLY PQESRSRERK ELNGLWSFRA DFSDNRRQGF 70 80 90 100 110 120 EQQWYRKPLR ESGPTLDMPV PSSFNDISQD GRLRSFIGWV WYEREAILPQ RWTQDLGTRV 130 140 150 160 170 180 VLRISSAHYY AIVWVNGVHV TEHEGGHLPF EADISKLVQT GPLSSCRITI AINNTLSPHT 190 200 210 220 230 240 LPPGTILYKT DTSKYPKGYF VQNTNFDFFN YAGLHRPVLL YTTPTAYIDD ITVTTDVDQD 250 260 270 280 290 300 TGLVNYQIFV QGSDHFQLEV HLLDEEGRVV AKGTGGQGQL QVPSAHLWWP YLMHERPAYL 310 320 330 340 350 360 YSLEVKLTAQ TSAGPLSDFY TLPVGIRTVA VTERQFLING KPFYFHGVNK HEDADIRGKG 370 380 390 400 410 420 FDWSLLVKDF NLLRWLGANA FRTSHYPYAE EVMQLCDRYG IVVIDESPGV GIVLAQSFSN 430 440 450 460 470 480 ASLQHHLEVM EEMVRRDKNH PAVVMWSVAN EPSSFLEQAA YYFKMLIGHT KALDPSRPVT 490 500 510 520 530 540 FVTSSSYEKD LGVPYVDVIC VNSYYSWYHD YGHMEVIQLQ LATQFERWHE AYQKPIIQSE 550 560 570 580 590 600 YGAETIIGFH EDPPLMFSEE YQKGLLQQYH VILDQKRKEY VVGELIWNFA DFMTDQSPQR 610 620 630 640 650 AIGNRKGIFT RQRQPKSAAF LLRERYWKLA NETRYLQSAV MSQCVGNSPF TV

References

[1]	Beck J., Knorr C., Brenig B. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ095863 Genomic DNA. Translation: AAZ03639.1.
RefSeq	NP_001116593.1.
UniGene	Ssc.18585
3D structure databases
SMR	Q4FAT7. Positions 24-632.
ModBase	Search...
Protein family/group databases
CAZy	GH2. Glycoside Hydrolase Family 2.
Genome annotation databases
GeneID	100144519.
KEGG	ssc:100144519.
Phylogenomic databases
HOVERGEN	Q4FAT7.
Enzyme and pathway databases
BRENDA	3.2.1.31. 249.
Family and domain databases
InterPro	IPR006101. Glyco_hydro_2. IPR013812. Glyco_hydro_2/20_Ig-like. IPR006104. Glyco_hydro_2_carb-bd. IPR006102. Glyco_hydro_2_Ig-like. IPR006103. Glyco_hydro_2_TIM. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view]
Gene3D	G3DSA:2.60.40.320. Glyco_hydro_2/20_Ig-like. 1 hit. G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF00703. Glyco_hydro_2. 1 hit. PF02836. Glyco_hydro_2_C. 1 hit. PF02837. Glyco_hydro_2_N. 1 hit. [Graphical view]
PRINTS	PR00132. GLHYDRLASE2.
PROSITE	PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit. PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BGLR_PIG

Accession

Primary (citable) accession number: Q4FAT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	August 30, 2005
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)