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Protein

Beta-glucuronidase

Gene

GUSB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the degradation of dermatan and keratan sulfates.By similarity

Catalytic activityi

A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.

Enzyme regulationi

Inhibited by L-aspartic acid.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei451Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-SSC-2024096 HS-GAG degradation
R-SSC-2160916 Hyaluronan uptake and degradation
R-SSC-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucuronidase (EC:3.2.1.31)
Gene namesi
Name:GUSB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000023159923 – 652Beta-glucuronidaseAdd BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4FAT7
PeptideAtlasiQ4FAT7
PRIDEiQ4FAT7

Expressioni

Gene expression databases

BgeeiENSSSCG00000007739
GenevisibleiQ4FAT7 SS

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008265

Structurei

3D structure databases

ProteinModelPortaliQ4FAT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2024 Eukaryota
COG3250 LUCA
HOGENOMiHOG000120896
HOVERGENiHBG004843
InParanoidiQ4FAT7
KOiK01195
OMAiQRWTQDL
OrthoDBiEOG091G02MO
TreeFamiTF300685

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SUPFAMiSSF49303 SSF49303, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4FAT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRGPAGAWA VLGPLLWGCG LALLQGGMLY PQESRSRERK ELNGLWSFRA
60 70 80 90 100
DFSDNRRQGF EQQWYRKPLR ESGPTLDMPV PSSFNDISQD GRLRSFIGWV
110 120 130 140 150
WYEREAILPQ RWTQDLGTRV VLRISSAHYY AIVWVNGVHV TEHEGGHLPF
160 170 180 190 200
EADISKLVQT GPLSSCRITI AINNTLSPHT LPPGTILYKT DTSKYPKGYF
210 220 230 240 250
VQNTNFDFFN YAGLHRPVLL YTTPTAYIDD ITVTTDVDQD TGLVNYQIFV
260 270 280 290 300
QGSDHFQLEV HLLDEEGRVV AKGTGGQGQL QVPSAHLWWP YLMHERPAYL
310 320 330 340 350
YSLEVKLTAQ TSAGPLSDFY TLPVGIRTVA VTERQFLING KPFYFHGVNK
360 370 380 390 400
HEDADIRGKG FDWSLLVKDF NLLRWLGANA FRTSHYPYAE EVMQLCDRYG
410 420 430 440 450
IVVIDESPGV GIVLAQSFSN ASLQHHLEVM EEMVRRDKNH PAVVMWSVAN
460 470 480 490 500
EPSSFLEQAA YYFKMLIGHT KALDPSRPVT FVTSSSYEKD LGVPYVDVIC
510 520 530 540 550
VNSYYSWYHD YGHMEVIQLQ LATQFERWHE AYQKPIIQSE YGAETIIGFH
560 570 580 590 600
EDPPLMFSEE YQKGLLQQYH VILDQKRKEY VVGELIWNFA DFMTDQSPQR
610 620 630 640 650
AIGNRKGIFT RQRQPKSAAF LLRERYWKLA NETRYLQSAV MSQCVGNSPF

TV
Length:652
Mass (Da):74,710
Last modified:August 30, 2005 - v1
Checksum:i7B9386564DFF2CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ095863 Genomic DNA Translation: AAZ03639.1
RefSeqiNP_001116593.1, NM_001123121.1
UniGeneiSsc.18585

Genome annotation databases

GeneIDi100144519
KEGGissc:100144519

Similar proteinsi

Entry informationi

Entry nameiBGLR_PIG
AccessioniPrimary (citable) accession number: Q4FAT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 30, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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