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Protein

Beta-glucuronidase

Gene

GUSB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the degradation of dermatan and keratan sulfates.By similarity

Catalytic activityi

A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.

Enzyme regulationi

Inhibited by L-aspartic acid.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei451Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-SSC-2024096. HS-GAG degradation.
R-SSC-2160916. Hyaluronan uptake and degradation.
R-SSC-6798695. Neutrophil degranulation.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucuronidase (EC:3.2.1.31)
Gene namesi
Name:GUSB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000023159923 – 652Beta-glucuronidaseAdd BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4FAT7.
PeptideAtlasiQ4FAT7.
PRIDEiQ4FAT7.

Expressioni

Gene expression databases

BgeeiENSSSCG00000007739.
GenevisibleiQ4FAT7. SS.

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008265.

Structurei

3D structure databases

ProteinModelPortaliQ4FAT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2024. Eukaryota.
COG3250. LUCA.
GeneTreeiENSGT00390000001752.
HOGENOMiHOG000120896.
HOVERGENiHBG004843.
InParanoidiQ4FAT7.
KOiK01195.
OMAiQRWTQDL.
OrthoDBiEOG091G02MO.
TreeFamiTF300685.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR023232. Glyco_hydro_2_AS.
IPR006103. Glyco_hydro_2_cat.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
PfamiView protein in Pfam
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
PRINTSiPR00132. GLHYDRLASE2.
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4FAT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRGPAGAWA VLGPLLWGCG LALLQGGMLY PQESRSRERK ELNGLWSFRA
60 70 80 90 100
DFSDNRRQGF EQQWYRKPLR ESGPTLDMPV PSSFNDISQD GRLRSFIGWV
110 120 130 140 150
WYEREAILPQ RWTQDLGTRV VLRISSAHYY AIVWVNGVHV TEHEGGHLPF
160 170 180 190 200
EADISKLVQT GPLSSCRITI AINNTLSPHT LPPGTILYKT DTSKYPKGYF
210 220 230 240 250
VQNTNFDFFN YAGLHRPVLL YTTPTAYIDD ITVTTDVDQD TGLVNYQIFV
260 270 280 290 300
QGSDHFQLEV HLLDEEGRVV AKGTGGQGQL QVPSAHLWWP YLMHERPAYL
310 320 330 340 350
YSLEVKLTAQ TSAGPLSDFY TLPVGIRTVA VTERQFLING KPFYFHGVNK
360 370 380 390 400
HEDADIRGKG FDWSLLVKDF NLLRWLGANA FRTSHYPYAE EVMQLCDRYG
410 420 430 440 450
IVVIDESPGV GIVLAQSFSN ASLQHHLEVM EEMVRRDKNH PAVVMWSVAN
460 470 480 490 500
EPSSFLEQAA YYFKMLIGHT KALDPSRPVT FVTSSSYEKD LGVPYVDVIC
510 520 530 540 550
VNSYYSWYHD YGHMEVIQLQ LATQFERWHE AYQKPIIQSE YGAETIIGFH
560 570 580 590 600
EDPPLMFSEE YQKGLLQQYH VILDQKRKEY VVGELIWNFA DFMTDQSPQR
610 620 630 640 650
AIGNRKGIFT RQRQPKSAAF LLRERYWKLA NETRYLQSAV MSQCVGNSPF

TV
Length:652
Mass (Da):74,710
Last modified:August 30, 2005 - v1
Checksum:i7B9386564DFF2CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ095863 Genomic DNA. Translation: AAZ03639.1.
RefSeqiNP_001116593.1. NM_001123121.1.
UniGeneiSsc.18585.

Genome annotation databases

EnsembliENSSSCT00000008484; ENSSSCP00000008265; ENSSSCG00000007739.
GeneIDi100144519.
KEGGissc:100144519.

Similar proteinsi

Entry informationi

Entry nameiBGLR_PIG
AccessioniPrimary (citable) accession number: Q4FAT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 30, 2005
Last modified: August 30, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families