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Q4F8I0 (ACDH1_PSEPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 1

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene names
Name:salG
OrganismPseudomonas pseudoalcaligenes
Taxonomic identifier330 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas oleovorans/pseudoalcaligenes group

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657
PRO_0000387706

Regions

Nucleotide binding162 – 1709NAD By similarity

Sites

Active site1311Acyl-thioester intermediate By similarity
Binding site2731NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4F8I0 [UniParc].

Last modified August 30, 2005. Version 1.
Checksum: F7EB363599B76C6A

FASTA30733,899
        10         20         30         40         50         60 
MSKKLKAAII GPGNIGTDLV MKMLRSEWIE PVWMVGIDPE SDGLKRARRF GLKTTAEGVD 

        70         80         90        100        110        120 
GLLPHVLEDD IRIAFDATSA YVHAENSRKL NEWGVLMVDL TPAAIGRYCV LRVNIKQNVG 

       130        140        150        160        170        180 
KLEMNVNMVT CGGQATSPMV AGVSRVQPVG YGKIVAKVFS RSIGPGTRKN IEEFNRTNAG 

       190        200        210        220        230        240 
AIEKVGGGKE GNAIIVLNTA HASFMICYTI HFFIKTEPDE NPIIPSVHPI IAELQNYFPG 

       250        260        270        280        290        300 
YRLKNRPLFY RNPFSIFIEF EPLADYLXNY PGNLDIMTPP ALPTLDIFPD KIAIATIQLP 


CLEPHLP 

« Hide

References

[1]"Cross-regulation of biphenyl- and salicylate-catabolic genes by two regulatory systems in Pseudomonas pseudoalcaligenes KF707."
Fujihara H., Yoshida H., Matsunaga T., Goto M., Furukawa K.
J. Bacteriol. 188:4690-4697(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: KF707.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ100350 Genomic DNA. Translation: AAZ08070.1.

3D structure databases

ProteinModelPortalQ4F8I0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH1_PSEPS
AccessionPrimary (citable) accession number: Q4F8I0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: August 30, 2005
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families