Reviewed, UniProtKB/Swiss-Prot Q4F867 (OXLA_DABRU)

Names and origin

Protein names	Recommended name:     L-amino-acid oxidase       Short name=LAAO       Short name=LAO     EC=1.4.3.2
Organism	Daboia russelli siamensis (Eastern Russell's viper) (Daboia russelli formensis)
Taxonomic identifier	343250 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Viperidae › Viperinae › Daboia

Protein attributes

Sequence length	392 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids. Inhibits platelet aggregation. Has an ability to induce apoptosis and hemorrhage. Has an antibacterial activity By similarity.
Catalytic activity	An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.
Cofactor	FAD By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Post-translational modification	Glycosylated By similarity.
Sequence similarities	Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Ontologies

Keywords
Biological process	Apoptosis Blood coagulation
Cellular component	Secreted
Ligand	FAD Flavoprotein
Molecular function	Antibiotic Antimicrobial Oxidoreductase Toxin
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-amino-acid oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 392	›392	L-amino-acid oxidase		PRO_0000315372
Regions
	Nucleotide binding	372 – 375	4	FAD By similarity
Sites
	Binding site	167	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	278	1	Substrate By similarity
	Binding site	363	1	FAD By similarity
Amino acid modifications
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Disulfide bond	237 ↔ 318		By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q4F867-1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 665DCF84C5837AAD	FASTA	392	44,594
	10 20 30 40 50 60 HRIVREYIRK FGLKLNEFVQ ETENGWYFIK NIRKRVGEVK KDPGLLKYPV KPSEAGKSAG 70 80 90 100 110 120 QLYQESLGKA VEELKRTNCS YILNKYDTYS TKEYLIKEGN LSPGAVDMIG DLLNEDSGYY 130 140 150 160 170 180 VSFIESLKHD DIFAYEKRFD EIVGGMDQLP TSMYRAIEES VRFKARVIKI QQNAEKVTVT 190 200 210 220 230 240 YQTTQKNLLL ETVDYVIVCT TSRAARRITF KPPLPPKKAH ALRSVHYRSG TKIFLTCTKK 250 260 270 280 290 300 FWEDDGIQGG KSTTDLPSRF IYYPNHNFTT GVGVIIAYGI GDDANFFQAL NLNECADIVF 310 320 330 340 350 360 NDLSSIHQLP KKDLQTFCYP SIIQKWSLDK YAMGAITTFT PYQFQHFSEA LTAPVGRIFF 370 380 390 AGEYTANAHG WIDSTIKSGL TAARDVNRAS EL

References

[1]	"Purification and characterization of an L-amino acid oxidase from Daboia russellii siamensis venom." Zhong S., Jin Y., Wu J., Jia Y., Xu G., Wang G., Li R., Wang W., Xiong Y. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ104365 mRNA. Translation: AAZ08620.1.
3D structure databases
SMR	Q4F867. Positions 1-391.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4F867.
Family and domain databases
InterPro	IPR002937. Amino_oxidase. [Graphical view]
Pfam	PF01593. Amino_oxidase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OXLA_DABRU

Accession

Primary (citable) accession number: Q4F867

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 30, 2005
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)