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Protein
Submitted name:

Brain adenylate cyclase 8

Gene

ADCY8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Brain adenylate cyclase 8Imported
Gene namesi
Name:ADCY8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei183 – 20220HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23219HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26724HelicalSequence analysisAdd
BLAST
Transmembranei287 – 30923HelicalSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Transmembranei704 – 72219HelicalSequence analysisAdd
BLAST
Transmembranei729 – 74921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29.

PTM / Processingi

Proteomic databases

PaxDbiQ4F7X0.
PRIDEiQ4F7X0.

Expressioni

Gene expression databases

GenevisibleiQ4F7X0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000286355.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini414 – 541128Guanylate cyclaseInterPro annotationAdd
BLAST
Domaini851 – 991141Guanylate cyclaseInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili799 – 82224Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08048.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4F7X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSDVRCLT GSEELYTIHP TPPAGDGRSA SRPQRLLWQT AVRHITEQRF
60 70 80 90 100
IHGHRGGSGS GSGGSGKASD PAGGGPNHHA PQLSGDSALP LYSLGPGERA
110 120 130 140 150
HSTCGTKVFP ERSGSGSASG SGGGGDLGFL HLDCAPSNSD FFLNGGYSYR
160 170 180 190 200
GVIFPTLRNS FKSRDLERLY QRYFLGQRRK SEVVMNVLDV LTKLTLLVLH
210 220 230 240 250
LSLASAPMDP LKGILLGFFT GIEVVICALV VVRKDTTSHT YLQYSGVVTW
260 270 280 290 300
VAMTTQILAA GLGYGLLGDG IGYVLFTLFA TYGMLPLPLT WAILAGLGTS
310 320 330 340 350
LLQVILQVVI PRLAVISINR VVAQAVLFMC MNTAGIFISY LSDRAQRQAF
360 370 380 390 400
LETRRCVEAR LRLETENQRQ ERLVLSVLPR FVVLEMINDM TNVEDGHLQH
410 420 430 440 450
QFHRIYIHRY ENVSILFADV KGFTNLSATL SAQELVRMLN ELFARFDRLV
460 470 480 490 500
HEHHCLRIKI LGDCYYCVSG LPEPRQDHAH CCVEMGLSMI KTIRYVRSRT
510 520 530 540 550
KHDVDMRIGI HSGSVLCGVL GLRKWQFDVW SWDVDIANKL ESGGIPGRIH
560 570 580 590 600
ISEATLDCLN GDYNVEEGHG KERNEFLGKH NIETYLIKQP EDSLLSLPED
610 620 630 640 650
IVKESVSSSD RRNSGATFTE GSWSPELPFD NIVGKQNTLA ALTRNSINLL
660 670 680 690 700
PNHLAQALHV QSGPEEINKR IEHTIDLRSG DKLRREHIKP FSLMFKDSSL
710 720 730 740 750
EHKYFVFTGV LAMVTCAVFL RLNSVLKLAV LLIMIAIYAP LTETVYAGLF
760 770 780 790 800
LRYDNLNHSG EDFLGTKEVS LLLMAMFLLA VFYHGQQLEY TARLDFLWRV
810 820 830 840 850
QAKEEINEMK ELREHNENML RNILPSHVAR HFLEKDQDNE ELYSQSYDAV
860 870 880 890 900
GVMFASIPGF ADFYSQTEMN NQGVECLRLL NEIIADFDEL LGEDRFQDIE
910 920 930 940 950
KIKTIGSTYM AVSGPSPEKQ QCEDKWGHLC ALADFSLALT ESIQEINKHS
960 970 980 990 1000
FNNFELRIGI SHGSVVAGVI GAKKPQYDIW GKTVNLASRM DSTGVSGRIQ
1010 1020 1030 1040 1050
VPEETYLILK DQGFAFDYRG EIYVKGISEQ EGKIKTYFLL GRVQPNPFIL
1060 1070 1080 1090 1100
PPRILPGQYS LAAVVLGLVQ SLNRQGQKQL LNENNNTGII KGHYNRRTLL
1110 1120
SPSGTEPGAQ AEGTDKSDLP
Length:1,120
Mass (Da):124,842
Last modified:August 30, 2005 - v1
Checksum:i618E235C2AB002C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104739 mRNA. Translation: AAZ13596.1.
RefSeqiNP_001106.1. NM_001115.2.
UniGeneiHs.591859.

Genome annotation databases

GeneIDi114.
KEGGihsa:114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104739 mRNA. Translation: AAZ13596.1.
RefSeqiNP_001106.1. NM_001115.2.
UniGeneiHs.591859.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000286355.

Proteomic databases

PaxDbiQ4F7X0.
PRIDEiQ4F7X0.

Protocols and materials databases

DNASUi114.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114.
KEGGihsa:114.

Organism-specific databases

CTDi114.
PharmGKBiPA29.

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08048.

Miscellaneous databases

ChiTaRSiADCY8. human.
GenomeRNAii114.
NextBioi441.

Gene expression databases

GenevisibleiQ4F7X0. HS.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Lin L., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Li H., Yang S.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ4F7X0_HUMAN
AccessioniPrimary (citable) accession number: Q4F7X0
Entry historyi
Integrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.