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Protein

Adenylate cyclase

Gene

ADCY8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.UniRule annotation

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processcAMP biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclaseUniRule annotation (EC:4.6.1.1UniRule annotation)
Gene namesi
Name:ADCY8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei183 – 202HelicalSequence analysisAdd BLAST20
Transmembranei214 – 232HelicalSequence analysisAdd BLAST19
Transmembranei244 – 267HelicalSequence analysisAdd BLAST24
Transmembranei287 – 309HelicalSequence analysisAdd BLAST23
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei704 – 722HelicalSequence analysisAdd BLAST19
Transmembranei729 – 749HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ4F7X0.
PRIDEiQ4F7X0.

Expressioni

Gene expression databases

GenevisibleiQ4F7X0. HS.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini414 – 541Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini851 – 991Guanylate cyclaseInterPro annotationAdd BLAST141

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili799 – 822Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08048.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiView protein in InterPro
IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
PfamiView protein in Pfam
PF16214. AC_N. 1 hit.
PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
PIRSFiPIRSF039050. Ade_cyc. 2 hits.
SMARTiView protein in SMART
SM00044. CYCc. 2 hits.
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiView protein in PROSITE
PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q4F7X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSDVRCLT GSEELYTIHP TPPAGDGRSA SRPQRLLWQT AVRHITEQRF
60 70 80 90 100
IHGHRGGSGS GSGGSGKASD PAGGGPNHHA PQLSGDSALP LYSLGPGERA
110 120 130 140 150
HSTCGTKVFP ERSGSGSASG SGGGGDLGFL HLDCAPSNSD FFLNGGYSYR
160 170 180 190 200
GVIFPTLRNS FKSRDLERLY QRYFLGQRRK SEVVMNVLDV LTKLTLLVLH
210 220 230 240 250
LSLASAPMDP LKGILLGFFT GIEVVICALV VVRKDTTSHT YLQYSGVVTW
260 270 280 290 300
VAMTTQILAA GLGYGLLGDG IGYVLFTLFA TYGMLPLPLT WAILAGLGTS
310 320 330 340 350
LLQVILQVVI PRLAVISINR VVAQAVLFMC MNTAGIFISY LSDRAQRQAF
360 370 380 390 400
LETRRCVEAR LRLETENQRQ ERLVLSVLPR FVVLEMINDM TNVEDGHLQH
410 420 430 440 450
QFHRIYIHRY ENVSILFADV KGFTNLSATL SAQELVRMLN ELFARFDRLV
460 470 480 490 500
HEHHCLRIKI LGDCYYCVSG LPEPRQDHAH CCVEMGLSMI KTIRYVRSRT
510 520 530 540 550
KHDVDMRIGI HSGSVLCGVL GLRKWQFDVW SWDVDIANKL ESGGIPGRIH
560 570 580 590 600
ISEATLDCLN GDYNVEEGHG KERNEFLGKH NIETYLIKQP EDSLLSLPED
610 620 630 640 650
IVKESVSSSD RRNSGATFTE GSWSPELPFD NIVGKQNTLA ALTRNSINLL
660 670 680 690 700
PNHLAQALHV QSGPEEINKR IEHTIDLRSG DKLRREHIKP FSLMFKDSSL
710 720 730 740 750
EHKYFVFTGV LAMVTCAVFL RLNSVLKLAV LLIMIAIYAP LTETVYAGLF
760 770 780 790 800
LRYDNLNHSG EDFLGTKEVS LLLMAMFLLA VFYHGQQLEY TARLDFLWRV
810 820 830 840 850
QAKEEINEMK ELREHNENML RNILPSHVAR HFLEKDQDNE ELYSQSYDAV
860 870 880 890 900
GVMFASIPGF ADFYSQTEMN NQGVECLRLL NEIIADFDEL LGEDRFQDIE
910 920 930 940 950
KIKTIGSTYM AVSGPSPEKQ QCEDKWGHLC ALADFSLALT ESIQEINKHS
960 970 980 990 1000
FNNFELRIGI SHGSVVAGVI GAKKPQYDIW GKTVNLASRM DSTGVSGRIQ
1010 1020 1030 1040 1050
VPEETYLILK DQGFAFDYRG EIYVKGISEQ EGKIKTYFLL GRVQPNPFIL
1060 1070 1080 1090 1100
PPRILPGQYS LAAVVLGLVQ SLNRQGQKQL LNENNNTGII KGHYNRRTLL
1110 1120
SPSGTEPGAQ AEGTDKSDLP
Length:1,120
Mass (Da):124,842
Last modified:August 30, 2005 - v1
Checksum:i618E235C2AB002C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104739 mRNA. Translation: AAZ13596.1.
RefSeqiNP_001106.1. NM_001115.2.
UniGeneiHs.591859.

Genome annotation databases

GeneIDi114.
KEGGihsa:114.

Similar proteinsi

Entry informationi

Entry nameiQ4F7X0_HUMAN
AccessioniPrimary (citable) accession number: Q4F7X0
Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2005
Last sequence update: August 30, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.