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Protein
Submitted name:

Thymidine kinase, putative

Gene

Tc00.1047053506855.260

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Thymidine kinase, putativeImported (EC:2.7.1.21Imported)
Gene namesi
ORF Names:Tc00.1047053506855.260Imported
OrganismiTrypanosoma cruzi (strain CL Brener)Imported
Taxonomic identifieri353153 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
Proteomesi
  • UP000002296 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 45HelicalSequence analysisAdd BLAST19
Transmembranei66 – 88HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500423743418 – 355Sequence analysisAdd BLAST338

Proteomic databases

PaxDbiQ4E1S0.

Interactioni

Protein-protein interaction databases

STRINGi353153.XP_820583.1.

Structurei

3D structure databases

ProteinModelPortaliQ4E1S0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3125. Eukaryota.
COG1435. LUCA.
KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4E1S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTLFFLFL LVWVVDCTPT HRFTLLYLIF AFPPFLFVVV VVMFASHTST
60 70 80 90 100
CTLKLRYAED QRNFRLAFGF CASSIQQLFA DISLQMMLEN ESHGHIELII
110 120 130 140 150
GPMFAGKTTE LMRRVRRELF AKRSCYVIKH SRDARYSRES VSSHDKLLLG
160 170 180 190 200
ATAAVAELRE VGDAWRPFDV VAVDEGQFFP DIVGFCNTAA DAGKTVIVSA
210 220 230 240 250
LDGDYRRQPF DGICRLIPLA ESVKKLTAVC MECHCRSASF TYRTVSSEKR
260 270 280 290 300
ELIGGADMYI AACRTCFVTK SKKRAEMEAK GSVQTVDKCS DTPAAEKQKG
310 320 330 340 350
EQREVEEDPI TPPTTIAAAE TPLSASAARK RPVDVDENVP TDAERCKSKA

RLECH
Length:355
Mass (Da):39,745
Last modified:September 13, 2005 - v1
Checksum:iE698AEE10A76400E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01000044 Genomic DNA. Translation: EAN98732.1.
RefSeqiXP_820583.1. XM_815490.1.

Genome annotation databases

EnsemblProtistsiEAN98732; EAN98732; Tc00.1047053506855.260.
GeneIDi3553296.
KEGGitcr:506855.260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01000044 Genomic DNA. Translation: EAN98732.1.
RefSeqiXP_820583.1. XM_815490.1.

3D structure databases

ProteinModelPortaliQ4E1S0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_820583.1.

Proteomic databases

PaxDbiQ4E1S0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAN98732; EAN98732; Tc00.1047053506855.260.
GeneIDi3553296.
KEGGitcr:506855.260.

Phylogenomic databases

eggNOGiKOG3125. Eukaryota.
COG1435. LUCA.
KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4E1S0_TRYCC
AccessioniPrimary (citable) accession number: Q4E1S0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 5, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.