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Q4DX91

- Q4DX91_TRYCC

UniProt

Q4DX91 - Q4DX91_TRYCC

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Protein

DNA ligase

Gene

Tc00.1047053506945.80

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Tc00.1047053506945.80Imported
OrganismiTrypanosoma cruzi (strain CL Brener)Imported
Taxonomic identifieri353153 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
ProteomesiUP000002296: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliQ4DX91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4DX91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAEAQEGNS VRLKRAREDF DCDKGVVDDL ALEDIFAGPT SMAKVFLKAS
60 70 80 90 100
FDPYVNYESV WPRPLPGVRE IVPYAAVADT LADISAESSR LECIKCLTNL
110 120 130 140 150
FLAVIQRSPS DLVSVIYLVI NKQGPAHEGI ELGVGDALLV KVIAECCGVT
160 170 180 190 200
EAYIKDAYRQ TGDLAEVAQN KKRQQSTLVK PKRLSAADVF KALRDIALMS
210 220 230 240 250
GKEASRRRAD VMKRLLRDAV GPEVNLIVRA LQQKMRVGLA ESSALAAIGY
260 270 280 290 300
AFALHHIGLT EVVKFTPEQL QRELNIGSDN FARIYHEVPS FEIVVGAMLK
310 320 330 340 350
HGFNVIVPSS PEGRAHAAEL SIRPGIPVKP QLAHPTSGIN AILERFQGKA
360 370 380 390 400
FTSEYKYDGE RAQIHYSKEK GYQIFSRNAE THTGKYPDII AMLPRVFSTE
410 420 430 440 450
AVESFIIDSE VVAVNKETGA LQAFQVLQHR GRKNVSFESV TIPVCVFAFD
460 470 480 490 500
ILYFNGSPQM TKPLLERRQV LYSYFTPIHA AFQFAEHLDG TDVEEIQSFL
510 520 530 540 550
DRSIKDGCEG LMVKTLKEEA AYTPAKRSYC WLKLKKDYMD GVTDTLDLVP
560 570 580 590 600
IGAYYGKGKR TGVFGGFLLA CYNSDSDEFQ SICKIGSGFL DEQLESLTQA
610 620 630 640 650
LQSCVLMEQP RYYRAEEKPD VWLEASNVWE VKAADLSISP VHFAAYGLVD
660 670 680 690
PSKGIALRFP RFVRVREDKK ANEATFATQI AAMYTAQSLS RKNYEEYDE
Length:699
Mass (Da):77,796
Last modified:September 13, 2005 - v1
Checksum:iCFF36DE30996A575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01000113 Genomic DNA. Translation: EAN97122.1.
RefSeqiXP_818973.1. XM_813880.1.

Genome annotation databases

GeneIDi3551354.
KEGGitcr:506945.80.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01000113 Genomic DNA. Translation: EAN97122.1 .
RefSeqi XP_818973.1. XM_813880.1.

3D structure databases

ProteinModelPortali Q4DX91.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3551354.
KEGGi tcr:506945.80.

Phylogenomic databases

KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease."
    El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anupama A., Arner E., Aslund L.
    , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B.
    Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CL BrenerImported.

Entry informationi

Entry nameiQ4DX91_TRYCC
AccessioniPrimary (citable) accession number: Q4DX91
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3