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Q4DX91

- Q4DX91_TRYCC

UniProt

Q4DX91 - Q4DX91_TRYCC

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Protein
DNA ligase
Gene
Tc00.1047053506945.80
Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Tc00.1047053506945.80Imported
OrganismiTrypanosoma cruzi (strain CL Brener)
Taxonomic identifieri353153 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
ProteomesiUP000002296: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliQ4DX91.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4DX91-1 [UniParc]FASTAAdd to Basket

« Hide

MGAEAQEGNS VRLKRAREDF DCDKGVVDDL ALEDIFAGPT SMAKVFLKAS    50
FDPYVNYESV WPRPLPGVRE IVPYAAVADT LADISAESSR LECIKCLTNL 100
FLAVIQRSPS DLVSVIYLVI NKQGPAHEGI ELGVGDALLV KVIAECCGVT 150
EAYIKDAYRQ TGDLAEVAQN KKRQQSTLVK PKRLSAADVF KALRDIALMS 200
GKEASRRRAD VMKRLLRDAV GPEVNLIVRA LQQKMRVGLA ESSALAAIGY 250
AFALHHIGLT EVVKFTPEQL QRELNIGSDN FARIYHEVPS FEIVVGAMLK 300
HGFNVIVPSS PEGRAHAAEL SIRPGIPVKP QLAHPTSGIN AILERFQGKA 350
FTSEYKYDGE RAQIHYSKEK GYQIFSRNAE THTGKYPDII AMLPRVFSTE 400
AVESFIIDSE VVAVNKETGA LQAFQVLQHR GRKNVSFESV TIPVCVFAFD 450
ILYFNGSPQM TKPLLERRQV LYSYFTPIHA AFQFAEHLDG TDVEEIQSFL 500
DRSIKDGCEG LMVKTLKEEA AYTPAKRSYC WLKLKKDYMD GVTDTLDLVP 550
IGAYYGKGKR TGVFGGFLLA CYNSDSDEFQ SICKIGSGFL DEQLESLTQA 600
LQSCVLMEQP RYYRAEEKPD VWLEASNVWE VKAADLSISP VHFAAYGLVD 650
PSKGIALRFP RFVRVREDKK ANEATFATQI AAMYTAQSLS RKNYEEYDE 699
Length:699
Mass (Da):77,796
Last modified:September 13, 2005 - v1
Checksum:iCFF36DE30996A575
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHK01000113 Genomic DNA. Translation: EAN97122.1.
RefSeqiXP_818973.1. XM_813880.1.

Genome annotation databases

GeneIDi3551354.
KEGGitcr:506945.80.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHK01000113 Genomic DNA. Translation: EAN97122.1 .
RefSeqi XP_818973.1. XM_813880.1.

3D structure databases

ProteinModelPortali Q4DX91.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3551354.
KEGGi tcr:506945.80.

Phylogenomic databases

KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease."
    El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anupama A., Arner E., Aslund L.
    , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B.
    Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CL BrenerImported.

Entry informationi

Entry nameiQ4DX91_TRYCC
AccessioniPrimary (citable) accession number: Q4DX91
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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