Q4DX91 (Q4DX91_TRYCC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

ORF Names:

Tc00.1047053506945.80 EMBL EAN97122.1

Organism

Trypanosoma cruzi (strain CL Brener) [Complete proteome]

Taxonomic identifier

353153 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum › Trypanosoma cruzi

Protein attributes

Sequence length	699 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617 EMBL EAN97122.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4DX91 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: CFF36DE30996A575	FASTA	699	77,796
	10 20 30 40 50 60 MGAEAQEGNS VRLKRAREDF DCDKGVVDDL ALEDIFAGPT SMAKVFLKAS FDPYVNYESV 70 80 90 100 110 120 WPRPLPGVRE IVPYAAVADT LADISAESSR LECIKCLTNL FLAVIQRSPS DLVSVIYLVI 130 140 150 160 170 180 NKQGPAHEGI ELGVGDALLV KVIAECCGVT EAYIKDAYRQ TGDLAEVAQN KKRQQSTLVK 190 200 210 220 230 240 PKRLSAADVF KALRDIALMS GKEASRRRAD VMKRLLRDAV GPEVNLIVRA LQQKMRVGLA 250 260 270 280 290 300 ESSALAAIGY AFALHHIGLT EVVKFTPEQL QRELNIGSDN FARIYHEVPS FEIVVGAMLK 310 320 330 340 350 360 HGFNVIVPSS PEGRAHAAEL SIRPGIPVKP QLAHPTSGIN AILERFQGKA FTSEYKYDGE 370 380 390 400 410 420 RAQIHYSKEK GYQIFSRNAE THTGKYPDII AMLPRVFSTE AVESFIIDSE VVAVNKETGA 430 440 450 460 470 480 LQAFQVLQHR GRKNVSFESV TIPVCVFAFD ILYFNGSPQM TKPLLERRQV LYSYFTPIHA 490 500 510 520 530 540 AFQFAEHLDG TDVEEIQSFL DRSIKDGCEG LMVKTLKEEA AYTPAKRSYC WLKLKKDYMD 550 560 570 580 590 600 GVTDTLDLVP IGAYYGKGKR TGVFGGFLLA CYNSDSDEFQ SICKIGSGFL DEQLESLTQA 610 620 630 640 650 660 LQSCVLMEQP RYYRAEEKPD VWLEASNVWE VKAADLSISP VHFAAYGLVD PSKGIALRFP 670 680 690 RFVRVREDKK ANEATFATQI AAMYTAQSLS RKNYEEYDE

References

[1]

"The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease." El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anapuma A., Arner E., Aslund L. , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B. Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CL Brener.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHK01000113 Genomic DNA. Translation: EAN97122.1.
RefSeq	XP_818973.1. XM_813880.1.
3D structure databases
ProteinModelPortal	Q4DX91.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3551354.
KEGG	tcr:506945.80.
Phylogenomic databases
KO	K10747.
ProtClustDB	CLSZ2441791.
Family and domain databases
Gene3D	1.10.3260.10. 1 hit. 2.40.50.140. 1 hit.
InterPro	IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4DX91_TRYCC

Accession

Primary (citable) accession number: Q4DX91

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	March 6, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)