Q4DQR5 (Q4DQR5_TRYCC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
3-hydroxy-3-methylglutaryl-CoA reductase, putative EMBL EAN94850.1

Gene names

ORF Names:

Tc00.1047053509167.20 EMBL EAN94850.1

Organism

Trypanosoma cruzi (strain CL Brener) [Complete proteome]

Taxonomic identifier

353153 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum › Trypanosoma cruzi

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the HMG-CoA reductase family. RuleBase RU004268

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	coenzyme A metabolic process Inferred from electronic annotation. Source: InterPro isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	NADP binding Inferred from electronic annotation. Source: InterPro hydroxymethylglutaryl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4DQR5 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: FA20681B95E401AF	FASTA	452	48,011
	10 20 30 40 50 60 MCIAKGIFKR SLSGKESMFR RAILLGCSAA KTPWSECSNA QLVDAVKSRK ISFYGLEQAL 70 80 90 100 110 120 EPDYRRAIEV RREVVSEIAS QQPEAKKKQS ALHTIPFENY DWNRVVGQNC ENIIGYVPIP 130 140 150 160 170 180 LGVAGPILID GKEYPIPMAT TEGALVASTH RGARAITRSG GCKTLLLGEG MTRAPVVELP 190 200 210 220 230 240 SLEEAGRLHK YCNENFLSLK EAFESTTQYG KLNSLKCVLA GRKAYLRFRA TTGDAMGMNM 250 260 270 280 290 300 ITKGVDKALS VLQQHFPSME ILALSGNYCT DKKPSAVNWI DGRGKSVVAE ATLLAEVVED 310 320 330 340 350 360 TLKCTVDSLV SLNIDKNLVG SAMAGSVGGF NAQAANAVAA IFIATGQDPA QVVESSMCIT 370 380 390 400 410 420 TMSKVGNDLL ISVTMPSIEV GVVGGGTGLA AQRGCLELIG CGGPSKESPG TNAQLLSRVV 430 440 450 AAGVLSAELS LMSGLAAGHL LSAHMRLNRK KK

References

[1]

"The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease." El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anapuma A., Arner E., Aslund L. , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B. Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CL Brener.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHK01000248 Genomic DNA. Translation: EAN94850.1.
RefSeq	XP_816701.1. XM_811608.1.
3D structure databases
ProteinModelPortal	Q4DQR5.
SMR	Q4DQR5. Positions 30-441.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3548635.
KEGG	tcr:509167.20.
Phylogenomic databases
KO	K00021.
ProtClustDB	CLSZ2430888.
Family and domain databases
Gene3D	1.10.3270.10. 1 hit. 3.30.70.420. 1 hit. 3.90.770.10. 2 hits.
InterPro	IPR002202. HMG_CoA_Rdtase. IPR023074. HMG_CoA_Rdtase_cat. IPR023076. HMG_CoA_Rdtase_CS. IPR004554. HMG_CoA_Rdtase_eu_arc. IPR023282. HMG_CoA_Rdtase_N. IPR009023. HMG_CoA_Rdtase_NAD(P)-bd. IPR009029. HMG_CoA_Rdtase_sub-bd. [Graphical view]
PANTHER	PTHR10572. PTHR10572. 1 hit.
Pfam	PF00368. HMG-CoA_red. 1 hit. [Graphical view]
PRINTS	PR00071. HMGCOARDTASE.
SUPFAM	SSF55035. HMG_CoA_NAD_bind. 1 hit. SSF56542. HMG_CoA_sub_bind. 1 hit.
TIGRFAMs	TIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITE	PS00066. HMG_COA_REDUCTASE_1. 1 hit. PS00318. HMG_COA_REDUCTASE_2. 1 hit. PS50065. HMG_COA_REDUCTASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4DQR5_TRYCC

Accession

Primary (citable) accession number: Q4DQR5

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	March 6, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)