ID   Q4DQE8_TRYCC            Unreviewed;       583 AA.
AC   Q4DQE8;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=DNA ligase, putative {ECO:0000313|EMBL:EAN94758.1};
DE            EC=6.5.1.1 {ECO:0000313|EMBL:EAN94758.1};
GN   ORFNames=Tc00.1047053506773.140 {ECO:0000313|EMBL:EAN94758.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN94758.1, ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN94758.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN94758.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAN94758.1}.
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DR   EMBL; AAHK01000254; EAN94758.1; -; Genomic_DNA.
DR   RefSeq; XP_816609.1; XM_811516.1.
DR   AlphaFoldDB; Q4DQE8; -.
DR   PaxDb; 353153-Q4DQE8; -.
DR   EnsemblProtists; EAN94758; EAN94758; Tc00.1047053506773.140.
DR   GeneID; 3548516; -.
DR   KEGG; tcr:506773.140; -.
DR   eggNOG; ENOG502R16X; Eukaryota.
DR   InParanoid; Q4DQE8; -.
DR   OMA; LFWIEEE; -.
DR   OrthoDB; 124958at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF5; LIGASE, PUTATIVE-RELATED; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000313|EMBL:EAN94758.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296}.
SQ   SEQUENCE   583 AA;  64491 MW;  CB3E8F8951F9D38F CRC64;
     MMKLHRILRS LPFVPMALST FDTIERSAAS STATDSTSHS FVSDGPPYFI SPKHDGVRIL
     SYVSEHAESL KSTCFSRFGR PVHGMFWIEE ELRLLRWLCG DPRLVLDGEL YVHKEPHARS
     TGDDGARTGF FSVSALVHRL RGPKSACSSE EEVLSYVASL PRLCVFDIVS FQPSDKTNLS
     EESSGRGLSR IEKERVSLLR EVMKANGVRD LEMLRVIPNY SVFSQRLKAM HFLMCVLHRA
     RASSILFPGR AVSVTTSKKH EMKRRNGNSS DMAVGVTNVG GEYLQLVKYS LLHSLDDAKK
     VYLKKYLSCG YEGAVIRSAS NVYELKEKER GVLLGLLDPL ISVGERPFVN KQAACWPKRS
     LLVAEAPPLL RTYAKNGLLA SMGSGEYDWT DFVADENEAE EANHQAVVGA AVRRAKQNAR
     RSTTAVKLLP FCDREYAILK PLLKIPSANP RARKLVSVPL KLLHGGRDAI SVPRTAFGKA
     ASKKNEKSKV AVFYGLQCLS ETGRVFNVSL PKMDVAKQRA LLDHLLEVTG GSRKMGGKRN
     TGGVGCRSLT GLYATVKYSS LTEYGIPRFG QVKAIRGGKG WFL
//