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Protein

Hexokinase

Gene

Tc00.1047053510121.20

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKQ4DQ27.

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
ORF Names:Tc00.1047053510121.20Imported
OrganismiTrypanosoma cruzi (strain CL Brener)Imported
Taxonomic identifieri353153 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
ProteomesiUP000002296: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliQ4DQ27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4DQ27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARLNNLLQ HIAVKDKDSD TMRHLKQRMA LASLANQFTV GKDHLKQLML
60 70 80 90 100
YMVHEMIEGL EGRESTLRML PSYVYKTDPS KATGVFYALD LGGTNFRVLR
110 120 130 140 150
VTCKEGRVAD RVDAKFVIPQ QALQGTAEDL FGFIAQSVKK MMEQKAPEDL
160 170 180 190 200
NRTVPLGFTF SFPTEQKGVD HGFLIKWTKG FSTRGVEGKD VVELLQKALK
210 220 230 240 250
RMEVKVKVVA LCNDTVGTLI TNYFFDPDTQ VGVIIGTGSN ACYFEDAYAV
260 270 280 290 300
TKEPSVAARG TTQTPINMEC GNFDSKYKFV LPVTAYDEAM DAVTPNRNYQ
310 320 330 340 350
TQEKMVSGMY LGEISRRMIA HLAELHCLPS ALASKMAKPW SFETKFMGMI
360 370 380 390 400
SADRMPGLQF TRQVFQELFH VDVTDVADLH VIRDVCCLVR GRAAQISAMF
410 420 430 440 450
CSAPLVKTRK EGRATVAIDG SVFEKTPSFR RLLQQNMNAI LGPGCDVTTA
460 470
LARDGSGIGA AFISALVVND K
Length:471
Mass (Da):52,196
Last modified:September 13, 2005 - v1
Checksum:iB189B527B8E12F2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01000263 Genomic DNA. Translation: EAN94612.1.
RefSeqiXP_816463.1. XM_811370.1.

Genome annotation databases

GeneIDi3548363.
KEGGitcr:510121.20.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01000263 Genomic DNA. Translation: EAN94612.1.
RefSeqiXP_816463.1. XM_811370.1.

3D structure databases

ProteinModelPortaliQ4DQ27.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3548363.
KEGGitcr:510121.20.

Phylogenomic databases

KOiK00844.

Enzyme and pathway databases

SABIO-RKQ4DQ27.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease."
    El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anupama A., Arner E., Aslund L.
    , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B.
    Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CL BrenerImported.

Entry informationi

Entry nameiQ4DQ27_TRYCC
AccessioniPrimary (citable) accession number: Q4DQ27
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 4, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.