ID   Q4DMH7_TRYCC            Unreviewed;       521 AA.
AC   Q4DMH7;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=DNA ligase, putative {ECO:0000313|EMBL:EAN93729.1};
DE            EC=6.5.1.1 {ECO:0000313|EMBL:EAN93729.1};
GN   ORFNames=Tc00.1047053508881.80 {ECO:0000313|EMBL:EAN93729.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN93729.1, ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN93729.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN93729.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAN93729.1}.
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DR   EMBL; AAHK01000329; EAN93729.1; -; Genomic_DNA.
DR   RefSeq; XP_815580.1; XM_810487.1.
DR   AlphaFoldDB; Q4DMH7; -.
DR   SMR; Q4DMH7; -.
DR   STRING; 353153.Q4DMH7; -.
DR   PaxDb; 353153-Q4DMH7; -.
DR   EnsemblProtists; EAN93729; EAN93729; Tc00.1047053508881.80.
DR   GeneID; 3547330; -.
DR   KEGG; tcr:508881.80; -.
DR   eggNOG; ENOG502QTYC; Eukaryota.
DR   InParanoid; Q4DMH7; -.
DR   OMA; VKAPRMV; -.
DR   OrthoDB; 142222at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR029319; DNA_ligase_OB.
DR   InterPro; IPR025487; DUF4379.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF3; LIGASE, PUTATIVE-RELATED; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF14743; DNA_ligase_OB_2; 1.
DR   Pfam; PF14311; DUF4379; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000313|EMBL:EAN93729.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT   DOMAIN          312..461
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   REGION          119..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  58923 MW;  B8460542FC3007F0 CRC64;
     MVVARIGART EMWRRCSCLG RAIVQSVDPS LLFGAGRPRT KQQAEKYKEL KNTTIQAAFP
     HLAACWVGPC WGTVMITPHH ISPLCLKMAV WRCSECLQEF EMSIAKFVDQ HGVCPLCKKP
     QRSLETPNKE PETTNGSSTE GKNGDSNLGS ATAMTMTTTT KNELVYAKAP RMIHTNYRSV
     LHDNPEWEEI NIQPMLAQKW ETVAAELLNP GPGEEKELLL ASPKIDGIRC LIGYNRRRKE
     PKFFSRGGIL LECCHGLVPH VMPLFEADPT LVLDGELFAP QCNFEELNGL VRRLEKFTTP
     EMRERQAQLL EYFSFDIMHS SQLSSPTAPF SERYRLLKKM VPTCGAKRIS AYQHDEEKRK
     IIRQKQRPDN AAAEGTIKLY HVPAAQVGAE EMDEVLEEAC SQGFEGVMIR RPGFPYEHGK
     RSFGLLKYKT MHDAEYRIVD FLPGQGKFRG GLGAFICETK TGIRFNATPK TTYENRLALW
     GKRQELLGKY LTVQYQELSS QDVPRFPVAK AVRGASEEEF L
//