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Protein

Histone deacetylase

Gene

Tc00.1047053508637.114

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101SubstrateUniRule annotation1
Active sitei143Proton acceptorUniRule annotation1
Binding sitei151Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi178Divalent metal cationUniRule annotation1
Metal bindingi180Divalent metal cationUniRule annotation1
Metal bindingi267Divalent metal cationUniRule annotation1
Binding sitei306SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:Tc00.1047053508637.114Imported
OrganismiTrypanosoma cruzi (strain CL Brener)Imported
Taxonomic identifieri353153 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
Proteomesi
  • UP000002296 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ4DLI6.

Interactioni

Protein-protein interaction databases

STRINGi353153.XP_815249.1.

Structurei

3D structure databases

ProteinModelPortaliQ4DLI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 322Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_dom_sf.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4DLI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVADIDRPV ALIDTSCYSA DCSLSALVPQ HAMKPYRLLV TMELIKSLGL
60 70 80 90 100
DRHCRTVVPP LIGIEQLQTY HAEDYISNLG LHSSQSWLWN TEISKVTFSG
110 120 130 140 150
DCPPVEGIME HSLSTVSGSL MAAILLNSGK ADTVIHWGGG MHHAKCGECS
160 170 180 190 200
GFCYVNDIVI AIIELLKCYK RVLYVDLDMH HGDGVDEAFC QSNRVFTLSL
210 220 230 240 250
HKFGESFFPG TGHPRDVGFG NGRHCTMNLA LWDGIDDFFY TTIFEHALSS
260 270 280 290 300
IVKRYIPDVV VLQCGADSLA GDRLGHFNLS SWGHGKCVEE VKKIGLPMLV
310 320 330 340 350
LGGGGYTLRN VAKLWAYETS ILCGKKLPLN TVVPVQRMPL SGWLFEGSTQ
360 370 380
LLVAQDEENK PLPGVNVQRA FRMVIEQIDK QCPNISFP
Length:388
Mass (Da):42,770
Last modified:September 13, 2005 - v1
Checksum:i5887291CA448845D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01000352 Genomic DNA. Translation: EAN93398.1.
RefSeqiXP_815249.1. XM_810156.1.

Genome annotation databases

EnsemblProtistsiEAN93398; EAN93398; Tc00.1047053508637.114.
GeneDBiTcCLB.508637.114:pep.
GeneIDi3546939.
KEGGitcr:508637.114.

Similar proteinsi

Entry informationi

Entry nameiQ4DLI6_TRYCC
AccessioniPrimary (citable) accession number: Q4DLI6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported