ID   Q4DIW6_TRYCC            Unreviewed;       521 AA.
AC   Q4DIW6;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=DNA ligase, putative {ECO:0000313|EMBL:EAN92478.1};
DE            EC=6.5.1.1 {ECO:0000313|EMBL:EAN92478.1};
GN   ORFNames=Tc00.1047053506287.200 {ECO:0000313|EMBL:EAN92478.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN92478.1, ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN92478.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN92478.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAN92478.1}.
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DR   EMBL; AAHK01000431; EAN92478.1; -; Genomic_DNA.
DR   RefSeq; XP_814329.1; XM_809236.1.
DR   AlphaFoldDB; Q4DIW6; -.
DR   SMR; Q4DIW6; -.
DR   STRING; 353153.Q4DIW6; -.
DR   PaxDb; 353153-Q4DIW6; -.
DR   EnsemblProtists; EAN92478; EAN92478; Tc00.1047053506287.200.
DR   GeneID; 3545849; -.
DR   KEGG; tcr:506287.200; -.
DR   eggNOG; ENOG502QTYC; Eukaryota.
DR   InParanoid; Q4DIW6; -.
DR   OrthoDB; 142222at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR029319; DNA_ligase_OB.
DR   InterPro; IPR025487; DUF4379.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF3; LIGASE, PUTATIVE-RELATED; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF14743; DNA_ligase_OB_2; 1.
DR   Pfam; PF14311; DUF4379; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000313|EMBL:EAN92478.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT   DOMAIN          312..461
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   REGION          123..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  58898 MW;  67C4D46BA24757B4 CRC64;
     MVLARIGART EMWRRCSCLG RAIVQSVDPS LLFGAGRPRT KQQAEKYKEL KNTTIQAAFP
     HLAACWVGPC WGTVMITPHH ISPLCLKIAV WRCSECLQEF EMSIAKFVDQ HGVCPLCKKP
     QRSLEAPNKE PETTNGSSTE GKNGDFNLGS AAAMKMTTTT KNEVVYAKAP RMIHTNYKSV
     LHDNPEWEEI NIQPMLAQKW ETVAAELLNP GPGEEKELLL ASPKIDGVRC LIGYNRRKKE
     PQFFSRSGIL LECCHGLVPH VMPLFEADPT LVLDGELFAP QCNFEELNGL VRRLEKFTTP
     EMRERQAQLL EYFSFDIMHS SQLSSSSAPF SERYRLLKKM VPTCGAKRIS AYQHDEEKRK
     IIRQKQRPDN AAAEGTIKLY HVPAAQVGAE EMDEVLEEAC SQGFEGVMIR RPGFPYEHGK
     RSFGLLKYKT MHDAEYRIVD FLPGQGKFRG GLGAFICETK TGIRFNATPK TTYENRLALW
     GKRQELLGKY LTVQYQELSS QDVPRFPVAK AVRGTSEEEF L
//