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Q4DGP3

- Q4DGP3_TRYCC

UniProt

Q4DGP3 - Q4DGP3_TRYCC

Protein

DNA ligase

Gene

Tc00.1047053506835.120

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    ORF Names:Tc00.1047053506835.120Imported
    OrganismiTrypanosoma cruzi (strain CL Brener)Imported
    Taxonomic identifieri353153 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
    ProteomesiUP000002296: Unassembled WGS sequence

    Structurei

    3D structure databases

    ProteinModelPortaliQ4DGP3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4DGP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAEAQEGNS VRLKRAREDF DCGKGIVDDV ALEDIFAGPT SMAKVFLKAS    50
    FDPYVNYESV WPRPLPGVRE IVPYAAVADT LADISAESSR LECIKCLTNL 100
    FLAVIQRSPS DLVSVIYLVI NKQGPAHEGI ELGVGDALLV KVIAECCGVT 150
    EAYIKDAYRQ TGDLAEVAQD KKRQQSTLVK PKRLSAADVF KALRDIALMS 200
    GKEASRRRAD VMKRLLRDAV GPEVNLIVRA LQQKMRVGLA ESSALAAIGY 250
    AFALHHIGLT EVVKFTPEQL QRELNIGSDN FARIYHEVPS FEIVVGAMLK 300
    HGFNVIVPSS PEGRAHAAEL SIRPGIPVKP QLAHPTSGIN AILERFQGKA 350
    FTSEYKYDGE RAQIHYSKEK GYQIFSRNAE THTGKYPDII AMLPRVFSTE 400
    AVESFIIDSE VVAVNKETGA LQAFQVLQHR GRKNVSFESV TIPVCVFAFD 450
    ILYFNGSPQM TKPLLERRQV LYSYFTPIHA AFQFAEHLDG TDVEEIQSFL 500
    DRSIKDGCEG LMVKTLKEEA AYTPAKRSYC WLKLKKDYMD GVTDTLDLVP 550
    IGAYYGKGKR TGVFGGFLLA CYNSDSDEFQ SICKIGSGFL DEQLESLTQA 600
    LQSFVLKEQP RYYRAEEKPD VWLEASNVWE VKAADLSISP VHFAAYGIVD 650
    PSKGIALRFP RFVRVREDKK ANEATFATQI AAMYTAQSLS RKNYEEYDEE 700
    T 701
    Length:701
    Mass (Da):78,109
    Last modified:September 13, 2005 - v1
    Checksum:i3A7D44521B43930C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHK01000501 Genomic DNA. Translation: EAN91701.1.
    RefSeqiXP_813552.1. XM_808459.1.

    Genome annotation databases

    GeneIDi3544944.
    KEGGitcr:506835.120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHK01000501 Genomic DNA. Translation: EAN91701.1 .
    RefSeqi XP_813552.1. XM_808459.1.

    3D structure databases

    ProteinModelPortali Q4DGP3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3544944.
    KEGGi tcr:506835.120.

    Phylogenomic databases

    KOi K10747.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease."
      El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anupama A., Arner E., Aslund L.
      , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B.
      Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CL BrenerImported.

    Entry informationi

    Entry nameiQ4DGP3_TRYCC
    AccessioniPrimary (citable) accession number: Q4DGP3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3