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Protein

Superoxide dismutase

Gene

Tc00.1047053509775.40

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Divalent metal cationUniRule annotation1
Metal bindingi59Iron; via tele nitrogenCombined sources1
Metal bindingi110Divalent metal cationUniRule annotation1
Metal bindingi110Iron; via tele nitrogenCombined sources1
Metal bindingi194Divalent metal cationUniRule annotation1
Metal bindingi194IronCombined sources1
Metal bindingi198Divalent metal cationUniRule annotation1
Metal bindingi198Iron; via tele nitrogenCombined sources1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandIronCombined sources, Metal-bindingUniRule annotationCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
ORF Names:Tc00.1047053509775.40Imported
OrganismiTrypanosoma cruzi (strain CL Brener)Imported
Taxonomic identifieri353153 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
Proteomesi
  • UP000002296 Componenti: Unassembled WGS sequence

PTM / Processingi

Proteomic databases

PaxDbiQ4DCQ3.

Interactioni

Protein-protein interaction databases

STRINGi353153.XP_812157.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DVHX-ray2.23A/B32-233[»]
4H3EX-ray2.25A/B1-233[»]
ProteinModelPortaliQ4DCQ3.
SMRiQ4DCQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 117Sod_Fe_NInterPro annotationAdd BLAST83
Domaini127 – 226Sod_Fe_CInterPro annotationAdd BLAST100

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0876. Eukaryota.
COG0605. LUCA.
KOiK04564.

Family and domain databases

InterProiView protein in InterPro
IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
PfamiView protein in Pfam
PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiView protein in PROSITE
PS00088. SOD_MN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4DCQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRAVNISI ARGRMALMSY ATLPDLLKPS GAPAELPKLG FNWKDGCAPV
60 70 80 90 100
FSPRQMELHY TKHHKAYVDK LNALAGTTYD GKSIEEIILA VANDAEKKGL
110 120 130 140 150
FNQAAQHFNH TFYFRCITPN GKAMPKSLES AVTAQFGSVE QFKDAFVQAG
160 170 180 190 200
VNNFGSGWTW LCVDPSNKNQ LVIDNTSNAG CPLTKGLRPV LAVDVWEHAY
210 220 230
YKDFENRRPD YLKEIWSVID WEFVAKMHAQ AIK
Length:233
Mass (Da):26,140
Last modified:September 13, 2005 - v1
Checksum:i96464D3997DF5797
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01000648 Genomic DNA. Translation: EAN90306.1.
RefSeqiXP_812157.1. XM_807064.1.

Genome annotation databases

EnsemblProtistsiEAN90306; EAN90306; Tc00.1047053509775.40.
GeneDBiTcCLB.509775.40:pep.
GeneIDi3543251.
KEGGitcr:509775.40.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ4DCQ3_TRYCC
AccessioniPrimary (citable) accession number: Q4DCQ3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: July 5, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported