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Q4DCQ3

- Q4DCQ3_TRYCC

UniProt

Q4DCQ3 - Q4DCQ3_TRYCC

Protein

Superoxide dismutase

Gene

Tc00.1047053509775.40

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation
    Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Iron; via tele nitrogenImported
    Metal bindingi110 – 1101Iron; via tele nitrogenImported
    Metal bindingi194 – 1941IronImported
    Metal bindingi198 – 1981Iron; via tele nitrogenImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Ligandi

    IronImported, Metal-bindingImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
    Gene namesi
    ORF Names:Tc00.1047053509775.40Imported
    OrganismiTrypanosoma cruzi (strain CL Brener)Imported
    Taxonomic identifieri353153 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
    ProteomesiUP000002296: Unassembled WGS sequence

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DVHX-ray2.23A/B32-233[»]
    4H3EX-ray2.25A/B1-233[»]
    ProteinModelPortaliQ4DCQ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

    Phylogenomic databases

    KOiK04564.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4DCQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRRAVNISI ARGRMALMSY ATLPDLLKPS GAPAELPKLG FNWKDGCAPV    50
    FSPRQMELHY TKHHKAYVDK LNALAGTTYD GKSIEEIILA VANDAEKKGL 100
    FNQAAQHFNH TFYFRCITPN GKAMPKSLES AVTAQFGSVE QFKDAFVQAG 150
    VNNFGSGWTW LCVDPSNKNQ LVIDNTSNAG CPLTKGLRPV LAVDVWEHAY 200
    YKDFENRRPD YLKEIWSVID WEFVAKMHAQ AIK 233
    Length:233
    Mass (Da):26,140
    Last modified:September 13, 2005 - v1
    Checksum:i96464D3997DF5797
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHK01000648 Genomic DNA. Translation: EAN90306.1.
    RefSeqiXP_812157.1. XM_807064.1.

    Genome annotation databases

    GeneIDi3543251.
    KEGGitcr:509775.40.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHK01000648 Genomic DNA. Translation: EAN90306.1 .
    RefSeqi XP_812157.1. XM_807064.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DVH X-ray 2.23 A/B 32-233 [» ]
    4H3E X-ray 2.25 A/B 1-233 [» ]
    ProteinModelPortali Q4DCQ3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3543251.
    KEGGi tcr:509775.40.

    Phylogenomic databases

    KOi K04564.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease."
      El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anupama A., Arner E., Aslund L.
      , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B.
      Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CL BrenerImported.
    2. "Crystal structure of a putative iron superoxide dismutase from Trypanosoma cruzi bound to iron."
      Seattle Structural Genomics Center for Infectious Disease (SSGCID)
      Edwards T.E., Clifton M.C.
      Submitted (SEP-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH IRON.
    3. "Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intramolecular electron transfer."
      Martinez A., Peluffo G., Petruk A.A., Hugo M., Pineyro D., Demicheli V., Moreno D.M., Lima A., Batthyany C., Duran R., Robello C., Marti M.A., Larrieux N., Buschiazzo A., Trujillo M., Radi R., Piacenza L.
      J. Biol. Chem. 289:12760-12778(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 32-233 IN COMPLEX WITH IRON.

    Entry informationi

    Entry nameiQ4DCQ3_TRYCC
    AccessioniPrimary (citable) accession number: Q4DCQ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3