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Q4DCQ3 (Q4DCQ3_TRYCC) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase RuleBase RU000414

EC=1.15.1.1 RuleBase RU000414
Gene names
ORF Names:Tc00.1047053509775.40 EMBL EAN90306.1
OrganismTrypanosoma cruzi (strain CL Brener) [Complete proteome]
Taxonomic identifier353153 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Sequence similarities

Belongs to the iron/manganese superoxide dismutase family. RuleBase RU004477

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. EMBL EAN90306.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding591Iron; via tele nitrogen PDB 4H3E PDB 4DVH
Metal binding1101Iron; via tele nitrogen PDB 4H3E PDB 4DVH
Metal binding1941Iron PDB 4H3E PDB 4DVH
Metal binding1981Iron; via tele nitrogen PDB 4H3E PDB 4DVH

Sequences

Sequence LengthMass (Da)Tools
Q4DCQ3 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 96464D3997DF5797

FASTA23326,140
        10         20         30         40         50         60 
MLRRAVNISI ARGRMALMSY ATLPDLLKPS GAPAELPKLG FNWKDGCAPV FSPRQMELHY 

        70         80         90        100        110        120 
TKHHKAYVDK LNALAGTTYD GKSIEEIILA VANDAEKKGL FNQAAQHFNH TFYFRCITPN 

       130        140        150        160        170        180 
GKAMPKSLES AVTAQFGSVE QFKDAFVQAG VNNFGSGWTW LCVDPSNKNQ LVIDNTSNAG 

       190        200        210        220        230 
CPLTKGLRPV LAVDVWEHAY YKDFENRRPD YLKEIWSVID WEFVAKMHAQ AIK 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease."
El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anupama A., Arner E., Aslund L. expand/collapse author list , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B.
Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CL Brener EMBL EAN90306.1.
[2]"Crystal structure of a putative iron superoxide dismutase from Trypanosoma cruzi bound to iron."
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Edwards T.E., Clifton M.C.
Submitted (SEP-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH IRON.
[3]"Structural and Molecular Basis of the Peroxynitrite-mediated Nitration and Inactivation of Trypanosoma cruzi Iron-Superoxide Dismutases (Fe-SODs) A and B: DISPARATE SUSCEPTIBILITIES DUE TO THE REPAIR OF TYR35 RADICAL BY CYS83 IN Fe-SODB THROUGH INTRAMOLECULAR ELECTRON TRANSFER."
Martinez A., Peluffo G., Petruk A.A., Hugo M., Pineyro D., Demicheli V., Moreno D.M., Lima A., Batthyany C., Duran R., Robello C., Marti M.A., Larrieux N., Buschiazzo A., Trujillo M., Radi R., Piacenza L.
J. Biol. Chem. 289:12760-12778(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 32-233 IN COMPLEX WITH IRON.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHK01000648 Genomic DNA. Translation: EAN90306.1.
RefSeqXP_812157.1. XM_807064.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4DVHX-ray2.23A/B32-233[»]
4H3EX-ray2.25A/B1-233[»]
ProteinModelPortalQ4DCQ3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3543251.
KEGGtcr:509775.40.

Phylogenomic databases

KOK04564.

Family and domain databases

InterProIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERPTHR11404. PTHR11404. 1 hit.
PfamPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFPIRSF000349. SODismutase. 1 hit.
PRINTSPR01703. MNSODISMTASE.
SUPFAMSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4DCQ3_TRYCC
AccessionPrimary (citable) accession number: Q4DCQ3
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)