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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

Tc00.1047053511909.40

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Tc00.1047053511909.40)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:Tc00.1047053511909.40Imported
OrganismiTrypanosoma cruzi (strain CL Brener)Imported
Taxonomic identifieri353153 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
ProteomesiUP000002296 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi353153.XP_809424.1.

Structurei

3D structure databases

ProteinModelPortaliQ4D4X1.
SMRiQ4D4X1. Positions 17-609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

KOiK00234.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4D4X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRIFARFS PKLSKAYPMI DHTFDCVVVG AGGSGLRAAM GVAASGYDVA
60 70 80 90 100
CISKLYPSRS HTIAAQGGIN AALANCEEDD WRWHVYDTVK GSDWLGDQDA
110 120 130 140 150
IQYMCQEAPC VVSELESMGL PFLRTKDGFI YQRAFGGQSI HFGGKQARRT
160 170 180 190 200
CAASDRTGHA MLHTLYGQSF QYGVNFFNEY YCLDLIVEDG CCRGVVAMSI
210 220 230 240 250
DDGTIHRFRS KYTILATGGY GRCWFTTTSA KSCTGDGTAM VARAGLPAED
260 270 280 290 300
MEFVQFHPTG IYGPGVLITE GARGEGGYLV NSEGERFMER YAPKAKDLAS
310 320 330 340 350
RDVVSRAITL EVLAGRGCGP KKDHVLLQLH HLPPEQLHEK LPGISESAHI
360 370 380 390 400
FAGVDVTKES IPIVPTVHYN MGGIPTLWTG EVVSPRNGDD DAIVPGLLAA
410 420 430 440 450
GECACASVHG ANRLGANSLL DIVVFGKSCA NTVIFNLTKE GRNQPELRPD
460 470 480 490 500
AGESSIADLD GILHNKGDIP VARIRERMKE TMALYAAVFR TEESMLKGQG
510 520 530 540 550
IIEECYRDYS HVFVHDKSPV WNSNLIEALE LRNLLTNALL TITGAAVRRE
560 570 580 590 600
SRGAHARDDY PERDDHNWMK HTLAYLDDKN GKARLAYRRV HNEMLTNELE

SIPPAKRVY
Length:609
Mass (Da):66,904
Last modified:September 13, 2005 - v1
Checksum:i629ECA1E39C2D8BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01001015 Genomic DNA. Translation: EAN87573.1.
RefSeqiXP_809424.1. XM_804331.1.

Genome annotation databases

GeneIDi3540028.
KEGGitcr:511909.40.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01001015 Genomic DNA. Translation: EAN87573.1.
RefSeqiXP_809424.1. XM_804331.1.

3D structure databases

ProteinModelPortaliQ4D4X1.
SMRiQ4D4X1. Positions 17-609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_809424.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3540028.
KEGGitcr:511909.40.

Phylogenomic databases

KOiK00234.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease."
    El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anupama A., Arner E., Aslund L.
    , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B.
    Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CL BrenerImported.

Entry informationi

Entry nameiQ4D4X1_TRYCC
AccessioniPrimary (citable) accession number: Q4D4X1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: July 22, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.