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Protein

Hexokinase

Gene

Tc00.1047053508951.20

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKQ4D3P5.

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
ORF Names:Tc00.1047053508951.20Imported
OrganismiTrypanosoma cruzi (strain CL Brener)Imported
Taxonomic identifieri353153 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
ProteomesiUP000002296 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi353153.XP_808992.1.

Structurei

3D structure databases

ProteinModelPortaliQ4D3P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4D3P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARLNNLLQ HIAVKDKDSD TMRHLKQRMA LASLANQFTV GKDHLKQLML
60 70 80 90 100
YMVHEMIEGL EGRESTLRML PSYVYKTDPS KATGVFYALD LGGTNFRVLR
110 120 130 140 150
VTCKEGRVAD RVDAKFVIPQ QALQGTAEDL FGFIAKSVKK MMEQKAPEDL
160 170 180 190 200
NRTVPLGFTF SFPTEQKGVD NGFLIKWTKG FSTRGVEGKD VVELLQNALK
210 220 230 240 250
RMEVKVKVVA LCNDTVGTLI TNYFFDPDTQ VGVIIGTGSN ACYFEDAYAV
260 270 280 290 300
TKEPSVAARG TTQTPINMEC GNFDSKYKFV LPVTAYDEAM DAVTPNRNYQ
310 320 330 340 350
TQEKMVSGMY LGEISRRMIA HLAELRCLPS ALASKMAKPW SFETKFMGMI
360 370 380 390 400
SADRMPGLQF TRQVLQELFH VDVTDVADLH VIRDVCCLVR GRAAQISAMF
410 420 430 440 450
CSAPLVKTRK EGRATVAIDG SVFEKTPSFR RLLQQNMNAI LGPGCDVTTA
460 470
LARDGSGIGA AFISALVVND K
Length:471
Mass (Da):52,144
Last modified:September 13, 2005 - v1
Checksum:i3AFC539931522158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01001082 Genomic DNA. Translation: EAN87141.1.
RefSeqiXP_808992.1. XM_803899.1.

Genome annotation databases

GeneIDi3539534.
KEGGitcr:508951.20.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHK01001082 Genomic DNA. Translation: EAN87141.1.
RefSeqiXP_808992.1. XM_803899.1.

3D structure databases

ProteinModelPortaliQ4D3P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_808992.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3539534.
KEGGitcr:508951.20.

Phylogenomic databases

KOiK00844.

Enzyme and pathway databases

SABIO-RKQ4D3P5.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease."
    El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B., Anupama A., Arner E., Aslund L.
    , Attipoe P., Bontempi E., Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D., Andersson B.
    Science 309:409-415(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CL BrenerImported.

Entry informationi

Entry nameiQ4D3P5_TRYCC
AccessioniPrimary (citable) accession number: Q4D3P5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: July 22, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.