ID   Q4CUQ5_TRYCC            Unreviewed;       344 AA.
AC   Q4CUQ5;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   24-JAN-2024, entry version 73.
DE   SubName: Full=Superoxide dismutase, putative {ECO:0000313|EMBL:EAN84009.1};
DE            EC=1.15.1.1 {ECO:0000313|EMBL:EAN84009.1};
GN   ORFNames=Tc00.1047053511735.60 {ECO:0000313|EMBL:EAN84009.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN84009.1, ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN84009.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN84009.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAN84009.1}.
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DR   EMBL; AAHK01001823; EAN84009.1; -; Genomic_DNA.
DR   RefSeq; XP_805860.1; XM_800767.1.
DR   AlphaFoldDB; Q4CUQ5; -.
DR   SMR; Q4CUQ5; -.
DR   STRING; 353153.Q4CUQ5; -.
DR   PaxDb; 353153-Q4CUQ5; -.
DR   EnsemblProtists; EAN84009; EAN84009; Tc00.1047053511735.60.
DR   GeneID; 3535737; -.
DR   KEGG; tcr:511735.60; -.
DR   eggNOG; KOG0876; Eukaryota.
DR   InParanoid; Q4CUQ5; -.
DR   OMA; FDHGTCP; -.
DR   OrthoDB; 166854at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; Fe,Mn superoxide dismutase (SOD) domain; 1.
DR   Gene3D; 3.55.40.20; Iron/manganese superoxide dismutase, C-terminal domain; 1.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   PANTHER; PTHR42769:SF4; DISMUTASE, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR42769; SUPEROXIDE DISMUTASE; 1.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   SUPFAM; SSF54719; Fe,Mn superoxide dismutase (SOD), C-terminal domain; 1.
DR   SUPFAM; SSF46609; Fe,Mn superoxide dismutase (SOD), N-terminal domain; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:EAN84009.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT   DOMAIN          246..329
FT                   /note="Manganese/iron superoxide dismutase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02777"
SQ   SEQUENCE   344 AA;  38568 MW;  6AE246651C888B2F CRC64;
     MVVEGKKLGG REAKGPFLSS HAWGWITHGM FLLLLLPMPL CFCSLWTHLH ACCCCPSGPL
     RLSPGQVERH AKGIVQQMRR TLRHGYHAYV PKGALLKTDM LASSPQLVTA VFRETEAAAE
     RADRANDDAG FFSRPRLNYP VASGIPAFIS RRQFDVQYNI FHHDAVETLN RHTLGTSLEG
     HSLETVIRRT SFDATQAAAH TAAAEHFNYC FFYKSLRPWG TAVPKQLREA FQLQYGRDGS
     VDVVEEVKRL LTVVVLSHQE RCGWVYLVWT GKQFDVVEFP HGACPIGSDL IPLLAINVHE
     GAYSLDYGLS GLEQYAQNYF RACNWFLAER YYLQATGRGS SCDA
//