Reviewed, UniProtKB/Swiss-Prot Q4AEI1 (GPX1_CEBAP)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 1
    EC=1.11.1.9
Alternative name(s):
    GSHPx-1
      Short name=GPx-1
    Cellular glutathione peroxidase

Gene names

Name:

GPX1

Organism

Cebus apella (Brown-capped capuchin)

Taxonomic identifier

9515 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Cebinae › Cebus

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Protects the hemoglobin in erythrocytes from oxidative breakdown By similarity.
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Selenocysteine
Ligand	Selenium
Molecular function	Oxidoreductase Peroxidase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Glutathione peroxidase 1		PRO_0000066609
Sites
	Active site	47	1	By similarity
Amino acid modifications
	Non-standard residue	47	1	Selenocysteine
	Modified residue	146	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4AEI1-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: E976C3CF4782BBD8	FASTA	201	21,785
	10 20 30 40 50 60 MCAAGLAAAA AQSVYAFSAR QLAGGEPVSL GSLRCKGLLI ENVASLUGTT VRDYTQMNEP 70 80 90 100 110 120 QRRLGPRGLV VLGFPCNHSG HQENAKNEEI LNSLKYVRPG GGFEPNFMLF EKGEVNGAGA 130 140 150 160 170 180 HTLFAFLREA LPAPSDDATA LMIDPKLITW SPVCRNDVAW NFEKFLVGPD GVPLRRYSRR 190 200 FQTIDIEPDI EALLSQGPSC A

References

[1]	"Structure, gene expression, and evolution of primate glutathione peroxidases." Fukuhara R., Kageyama T. Comp. Biochem. Physiol. 141B:428-436(2005) [PubMed: 15967696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB120999 mRNA. Translation: BAE17009.1.
3D structure databases
SMR	Q4AEI1. Positions 12-195.
ModBase	Search...
Protein family/group databases
PeroxiBase	3638. CapGPx01.
Phylogenomic databases
HOVERGEN	Q4AEI1.
Enzyme and pathway databases
BRENDA	1.11.1.9. 293018.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. False negative. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX1_CEBAP

Accession

Primary (citable) accession number: Q4AEI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	February 26, 2008
Last modified:	June 16, 2009
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)