Reviewed, UniProtKB/Swiss-Prot Q4AEI0 (GPX2_PONPY)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 2
    EC=1.11.1.9
Alternative name(s):
    GSHPx-2
      Short name=GPx-2
    Glutathione peroxidase-gastrointestinal
    GSHPx-GI

Gene names

Name:

GPX2

Organism

Pongo pygmaeus (Bornean orangutan)

Taxonomic identifier

9600 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Subunit structure	Homotetramer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.
Sequence caution	The sequence CAH90226.1 differs from that shown. Reason: Erroneous termination at position 40. Translated as Sec. The sequence CAH90226.1 differs from that shown. Reason: Frameshift at position 183.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Selenocysteine
Ligand	Selenium
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Glutathione peroxidase 2		PRO_0000066623
Sites
	Active site	40	1	By similarity
Amino acid modifications
	Non-standard residue	40	1	Selenocysteine

Sequences

	Sequence		Length	Mass (Da)
	Q4AEI0-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 48904FB5D91F5FA1	FASTA	190	21,984
	10 20 30 40 50 60 MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL NELQCRFPRR 70 80 90 100 110 120 LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGSGYQPTFT LVQKCEVNGQ NEHPVFAYLK 130 140 150 160 170 180 DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP 190 DIKRLLKVAI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, gene expression, and evolution of primate glutathione peroxidases." Fukuhara R., Kageyama T. Comp. Biochem. Physiol. 141B:428-436(2005) [PubMed: 15967696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB121001 mRNA. Translation: BAE17010.1. CR857983 mRNA. Translation: CAH90226.1. Sequence problems.
3D structure databases
SMR	Q4AEI0. Positions 4-187.
ModBase	Search...
Protein family/group databases
PeroxiBase	3726. PpyGPx02.
Phylogenomic databases
HOVERGEN	Q4AEI0.
Family and domain databases
InterPro	IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX2_PONPY

Accession

Primary (citable) accession number: Q4AEI0
Secondary accession number(s): Q5RDD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	February 26, 2008
Last modified:	November 25, 2008
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)