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Q4AEH9 (GPX2_HYLLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione peroxidase 2

Short name=GPx-2
Short name=GSHPx-2
EC=1.11.1.9
Alternative name(s):
Glutathione peroxidase-gastrointestinal
Short name=GPx-GI
Short name=GSHPx-GI
Gene names
Name:GPX2
OrganismHylobates lar (Common gibbon) (White-handed gibbon)
Taxonomic identifier9580 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeHylobates

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversitySelenocysteine
   Molecular functionOxidoreductase
Peroxidase
Gene Ontology (GO)
   Biological_processresponse to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione peroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Glutathione peroxidase 2
PRO_0000066620

Sites

Active site401 By similarity

Amino acid modifications

Non-standard residue401Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
Q4AEH9 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: FC8C4E69C4DE83A0

FASTA19021,954
        10         20         30         40         50         60 
MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL NELQCRFPRR 

        70         80         90        100        110        120 
LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK 

       130        140        150        160        170        180 
DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP 

       190 
DIKRLLKVAI 

« Hide

References

[1]"Structure, gene expression, and evolution of primate glutathione peroxidases."
Fukuhara R., Kageyama T.
Comp. Biochem. Physiol. 141B:428-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB121002 mRNA. Translation: BAE17011.1.

3D structure databases

ProteinModelPortalQ4AEH9.
SMRQ4AEH9. Positions 4-187.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

PeroxiBase3697. HlGPx02.

Proteomic databases

PRIDEQ4AEH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004333.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11592. PTHR11592. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPX2_HYLLA
AccessionPrimary (citable) accession number: Q4AEH9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: February 26, 2008
Last modified: October 16, 2013
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families