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Q4AEH8

- GPX2_MACFU

UniProt

Q4AEH8 - GPX2_MACFU

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Protein

Glutathione peroxidase 2

Gene
GPX2
Organism
Macaca fuscata fuscata (Japanese macaque)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401 By similarity

GO - Molecular functioni

  1. glutathione peroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei3705. MfGPx02.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 2 (EC:1.11.1.9)
Short name:
GPx-2
Short name:
GSHPx-2
Alternative name(s):
Glutathione peroxidase-gastrointestinal
Short name:
GPx-GI
Short name:
GSHPx-GI
Gene namesi
Name:GPX2
OrganismiMacaca fuscata fuscata (Japanese macaque)
Taxonomic identifieri9543 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Glutathione peroxidase 2PRO_0000066621Add
BLAST

Expressioni

Tissue specificityi

Exclusively expressed in the stomach and small intestine.1 Publication

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ4AEH8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG004333.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4AEH8-1 [UniParc]FASTAAdd to Basket

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MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL    50
NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT 100
LVQKCEVNGQ NEHPVFAYLK DKLPYPHDDP FSLMTDPKLI IWSPVRRSDV 150
AWNFEKFLIG PEVEPFRRYS RTFPTINIEP DIKRLLKVAI 190
Length:190
Mass (Da):21,970
Last modified:February 26, 2008 - v2
Checksum:iE63C54D365DF83B1
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei40 – 401Selenocysteine

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB121003 mRNA. Translation: BAE17012.1.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB121003 mRNA. Translation: BAE17012.1 .

3D structure databases

ProteinModelPortali Q4AEH8.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

PeroxiBasei 3705. MfGPx02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004333.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11592. PTHR11592. 1 hit.
Pfami PF00255. GSHPx. 1 hit.
[Graphical view ]
PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
PRINTSi PR01011. GLUTPROXDASE.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure, gene expression, and evolution of primate glutathione peroxidases."
    Fukuhara R., Kageyama T.
    Comp. Biochem. Physiol. 141B:428-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPX2_MACFU
AccessioniPrimary (citable) accession number: Q4AEH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: February 26, 2008
Last modified: October 16, 2013
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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