Reviewed, UniProtKB/Swiss-Prot Q4AEH7 (GPX2_CEBAP)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 2
    EC=1.11.1.9
Alternative name(s):
    GSHPx-2
      Short name=GPx-2
    Glutathione peroxidase-gastrointestinal
    GSHPx-GI

Gene names

Name:

GPX2

Organism

Cebus apella (Brown-capped capuchin)

Taxonomic identifier

9515 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Cebinae › Cebus

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Selenocysteine
Ligand	Selenium
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Glutathione peroxidase 2		PRO_0000066618
Sites
	Active site	40	1	By similarity
Amino acid modifications
	Non-standard residue	40	1	Selenocysteine

Sequences

	Sequence		Length	Mass (Da)
	Q4AEH7-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: E63C54CEDBF62C94	FASTA	190	21,909
	10 20 30 40 50 60 MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL NELQCRFPRR 70 80 90 100 110 120 LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK 130 140 150 160 170 180 DKLPYPHDDP FSLMTDPKFI IWSPVCRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP 190 DIKRLLKVAI

References

[1]	"Structure, gene expression, and evolution of primate glutathione peroxidases." Fukuhara R., Kageyama T. Comp. Biochem. Physiol. 141B:428-436(2005) [PubMed: 15967696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB121004 mRNA. Translation: BAE17013.1.
3D structure databases
SMR	Q4AEH7. Positions 4-187.
ModBase	Search...
Protein family/group databases
PeroxiBase	3639. CapGPx02.
Phylogenomic databases
HOVERGEN	Q4AEH7.
Enzyme and pathway databases
BRENDA	1.11.1.9. 293018.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX2_CEBAP

Accession

Primary (citable) accession number: Q4AEH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	February 26, 2008
Last modified:	June 16, 2009
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)