Reviewed, UniProtKB/Swiss-Prot Q4AEH4 (GPX3_MACFU)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 3
    EC=1.11.1.9
Alternative name(s):
    GSHPx-3
      Short name=GPx-3
    Plasma glutathione peroxidase
    GSHPx-P

Gene names

Name:

GPX3

Organism

Macaca fuscata fuscata (Japanese macaque)

Taxonomic identifier

9543 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione By similarity.
Catalytic activity	2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Subunit structure	Homotetramer By similarity.
Subcellular location	SecretedBy similarity.
Tissue specificity	Expressed intensively in the kidney and adrenal gland, and weakly in the cerebellum, heart, and lung. Secreted in plasma. Ref.1
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Selenocysteine
Domain	Signal
Ligand	Selenium
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	glutathione peroxidase activity Inferred from sequence or structural similarity. Source: UniProtKB selenium binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 226	202	Glutathione peroxidase 3		PRO_0000042606
Sites
	Active site	73	1	By similarity
Amino acid modifications
	Non-standard residue	73	1	Selenocysteine

Sequences

	Sequence		Length	Mass (Da)
	Q4AEH4-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: CD13D80423FEB17E	FASTA	226	25,576
	10 20 30 40 50 60 MARLLQASCL LSLLLAGFLP QSRGQDKSKM DCHGGVSGTI YEYGALTIDG EEYIPFKQYI 70 80 90 100 110 120 GKYVLFVNVA SYUGLTGQYI ELNALQEELA PFGLVLLGFP CNQFGKQEPG ENSEILPSLK 130 140 150 160 170 180 YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT FLKNSCPPTS ELLGTSDRLF WEPMKVHDIR 190 200 210 220 WNFEKFLVGP DGIPVMRWHH RTTISNVKMD ILSYMRRQAA LGVKRK

References

[1]	"Structure, gene expression, and evolution of primate glutathione peroxidases." Fukuhara R., Kageyama T. Comp. Biochem. Physiol. 141B:428-436(2005) [PubMed: 15967696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB121008 mRNA. Translation: BAE17016.1.
3D structure databases
ModBase	Search...
Protein family/group databases
PeroxiBase	3706. MfGPx03.
Phylogenomic databases
HOVERGEN	Q4AEH4.
Family and domain databases
InterPro	IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX3_MACFU

Accession

Primary (citable) accession number: Q4AEH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	February 26, 2008
Last modified:	November 25, 2008
This is version 22 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)