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Q4AEG6

- BMP10_RAT

UniProt

Q4AEG6 - BMP10_RAT

Protein

Bone morphogenetic protein 10

Gene

Bmp10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines By similarity.By similarity

    GO - Biological processi

    1. activin receptor signaling pathway Source: Ensembl
    2. adult heart development Source: Ensembl
    3. atrial cardiac muscle tissue morphogenesis Source: Ensembl
    4. BMP signaling pathway Source: Ensembl
    5. cardiac muscle cell proliferation Source: Ensembl
    6. cell adhesion Source: UniProtKB-KW
    7. heart trabecula formation Source: Ensembl
    8. negative regulation of cardiac muscle hypertrophy Source: Ensembl
    9. negative regulation of cell growth Source: Ensembl
    10. negative regulation of endothelial cell migration Source: Ensembl
    11. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    12. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    13. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
    14. positive regulation of cell proliferation involved in heart morphogenesis Source: Ensembl
    15. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    16. positive regulation of sarcomere organization Source: Ensembl
    17. positive regulation of transcription, DNA-templated Source: Ensembl
    18. regulation of cardiac muscle contraction Source: Ensembl
    19. sarcomere organization Source: BHF-UCL
    20. ventricular cardiac muscle cell development Source: Ensembl
    21. ventricular cardiac muscle tissue morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_198592. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 10
    Short name:
    BMP-10
    Gene namesi
    Name:Bmp10Imported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1562986. Bmp10.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: UniProtKB-KW
    3. Z disc Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 313292Sequence AnalysisPRO_0000310575Add
    BLAST
    Chaini314 – 421108Bone morphogenetic protein 10Sequence AnalysisPRO_0000310576Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi320 ↔ 386By similarity
    Disulfide bondi349 ↔ 418By similarity
    Disulfide bondi353 ↔ 420By similarity
    Disulfide bondi385 – 385InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ4AEG6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4AEG6.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012365.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4AEG6.
    SMRiQ4AEG6. Positions 317-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG280573.
    GeneTreeiENSGT00740000115456.
    HOGENOMiHOG000249477.
    HOVERGENiHBG106648.
    InParanoidiQ4AEG6.
    KOiK05503.
    OMAiNVSIPHH.
    OrthoDBiEOG7ZD1V3.
    PhylomeDBiQ4AEG6.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4AEG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLVLPLSA VFCLVARLAS GSPIMGLEQS PLEEDMPFFD DIFTEQDGID    50
    FNTLLQSMKD EFLKTLNLSD IPPQDTGRVD PPEYMLELYN KFATDRTSMP 100
    SANIIRSFKN EDLFSQPVSF NGIRKYPLLF NVSIPHHEEV VMAELRLYTL 150
    VQRDRLMYDG VDRKIIIFEV LESADGSEDE RSMLVLVSTE IYGTNSEWET 200
    FDITDATRRW QKSGPSTHQL EIHIESRQNQ AEDTGRGQLE IDMSAQNKHD 250
    PLLVVFSDDQ SGDKEQKEEL NELISHEQDL DLGTDGFFGG PDEEALLQMR 300
    SNMIDDSTAR IRRNAKGNYC KKTPLYIDFK EIGWDSWIIA PPGYEAYECR 350
    GVCNYPLAEH LTPTKHAIIQ ALVHLKNSQK ASKACCVPTK LDPISILYLD 400
    KGVVTYKFKY EGMAVSECGC R 421
    Length:421
    Mass (Da):47,767
    Last modified:September 13, 2005 - v1
    Checksum:i94E1496B7BEDFD36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB158417 mRNA. Translation: BAE16989.1.
    AB158418 mRNA. Translation: BAE16990.1.
    RefSeqiNP_001026994.1. NM_001031824.1.
    UniGeneiRn.118010.

    Genome annotation databases

    EnsembliENSRNOT00000012365; ENSRNOP00000012365; ENSRNOG00000009316.
    GeneIDi500245.
    KEGGirno:500245.
    UCSCiRGD:1562986. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB158417 mRNA. Translation: BAE16989.1 .
    AB158418 mRNA. Translation: BAE16990.1 .
    RefSeqi NP_001026994.1. NM_001031824.1.
    UniGenei Rn.118010.

    3D structure databases

    ProteinModelPortali Q4AEG6.
    SMRi Q4AEG6. Positions 317-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012365.

    Proteomic databases

    PRIDEi Q4AEG6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000012365 ; ENSRNOP00000012365 ; ENSRNOG00000009316 .
    GeneIDi 500245.
    KEGGi rno:500245.
    UCSCi RGD:1562986. rat.

    Organism-specific databases

    CTDi 27302.
    RGDi 1562986. Bmp10.

    Phylogenomic databases

    eggNOGi NOG280573.
    GeneTreei ENSGT00740000115456.
    HOGENOMi HOG000249477.
    HOVERGENi HBG106648.
    InParanoidi Q4AEG6.
    KOi K05503.
    OMAi NVSIPHH.
    OrthoDBi EOG7ZD1V3.
    PhylomeDBi Q4AEG6.
    TreeFami TF316134.

    Enzyme and pathway databases

    Reactomei REACT_198592. Molecules associated with elastic fibres.

    Miscellaneous databases

    NextBioi 705556.
    PROi Q4AEG6.

    Gene expression databases

    Genevestigatori Q4AEG6.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines."
      Tsuji A.B., Sugyo A., Ogiu T., Sagara M., Kimura T., Ishikawa A., Sudo H., Ohtsuki M., Aburatani H., Imai T., Harada Y.N.
      Genomics 86:271-279(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Fischer 344/DuCrjImported and LEC/CrjImported.

    Entry informationi

    Entry nameiBMP10_RAT
    AccessioniPrimary (citable) accession number: Q4AEG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Does not appear to contribute to radiation susceptibility in the LEC strain.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3