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Q4AEG6

- BMP10_RAT

UniProt

Q4AEG6 - BMP10_RAT

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Protein

Bone morphogenetic protein 10

Gene

Bmp10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines (By similarity).By similarity

GO - Biological processi

  1. activin receptor signaling pathway Source: Ensembl
  2. adult heart development Source: Ensembl
  3. atrial cardiac muscle tissue morphogenesis Source: Ensembl
  4. BMP signaling pathway Source: Ensembl
  5. cardiac muscle cell proliferation Source: Ensembl
  6. cell adhesion Source: UniProtKB-KW
  7. heart trabecula formation Source: Ensembl
  8. negative regulation of cardiac muscle hypertrophy Source: Ensembl
  9. negative regulation of cell growth Source: Ensembl
  10. negative regulation of endothelial cell migration Source: Ensembl
  11. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  12. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  13. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
  14. positive regulation of cell proliferation involved in heart morphogenesis Source: Ensembl
  15. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  16. positive regulation of sarcomere organization Source: Ensembl
  17. positive regulation of transcription, DNA-templated Source: Ensembl
  18. regulation of cardiac muscle contraction Source: Ensembl
  19. sarcomere organization Source: BHF-UCL
  20. ventricular cardiac muscle cell development Source: Ensembl
  21. ventricular cardiac muscle tissue morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_198592. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 10
Short name:
BMP-10
Gene namesi
Name:Bmp10Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1562986. Bmp10.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
  3. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 313292Sequence AnalysisPRO_0000310575Add
BLAST
Chaini314 – 421108Bone morphogenetic protein 10Sequence AnalysisPRO_0000310576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi320 ↔ 386By similarity
Disulfide bondi349 ↔ 418By similarity
Disulfide bondi353 ↔ 420By similarity
Disulfide bondi385 – 385InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ4AEG6.

Expressioni

Gene expression databases

GenevestigatoriQ4AEG6.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012365.

Structurei

3D structure databases

ProteinModelPortaliQ4AEG6.
SMRiQ4AEG6. Positions 317-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Sequence Analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG280573.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249477.
HOVERGENiHBG106648.
InParanoidiQ4AEG6.
KOiK05503.
OMAiNVSIPHH.
OrthoDBiEOG7ZD1V3.
PhylomeDBiQ4AEG6.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4AEG6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSLVLPLSA VFCLVARLAS GSPIMGLEQS PLEEDMPFFD DIFTEQDGID
60 70 80 90 100
FNTLLQSMKD EFLKTLNLSD IPPQDTGRVD PPEYMLELYN KFATDRTSMP
110 120 130 140 150
SANIIRSFKN EDLFSQPVSF NGIRKYPLLF NVSIPHHEEV VMAELRLYTL
160 170 180 190 200
VQRDRLMYDG VDRKIIIFEV LESADGSEDE RSMLVLVSTE IYGTNSEWET
210 220 230 240 250
FDITDATRRW QKSGPSTHQL EIHIESRQNQ AEDTGRGQLE IDMSAQNKHD
260 270 280 290 300
PLLVVFSDDQ SGDKEQKEEL NELISHEQDL DLGTDGFFGG PDEEALLQMR
310 320 330 340 350
SNMIDDSTAR IRRNAKGNYC KKTPLYIDFK EIGWDSWIIA PPGYEAYECR
360 370 380 390 400
GVCNYPLAEH LTPTKHAIIQ ALVHLKNSQK ASKACCVPTK LDPISILYLD
410 420
KGVVTYKFKY EGMAVSECGC R
Length:421
Mass (Da):47,767
Last modified:September 13, 2005 - v1
Checksum:i94E1496B7BEDFD36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB158417 mRNA. Translation: BAE16989.1.
AB158418 mRNA. Translation: BAE16990.1.
RefSeqiNP_001026994.1. NM_001031824.1.
UniGeneiRn.118010.

Genome annotation databases

EnsembliENSRNOT00000012365; ENSRNOP00000012365; ENSRNOG00000009316.
GeneIDi500245.
KEGGirno:500245.
UCSCiRGD:1562986. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB158417 mRNA. Translation: BAE16989.1 .
AB158418 mRNA. Translation: BAE16990.1 .
RefSeqi NP_001026994.1. NM_001031824.1.
UniGenei Rn.118010.

3D structure databases

ProteinModelPortali Q4AEG6.
SMRi Q4AEG6. Positions 317-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000012365.

Proteomic databases

PRIDEi Q4AEG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000012365 ; ENSRNOP00000012365 ; ENSRNOG00000009316 .
GeneIDi 500245.
KEGGi rno:500245.
UCSCi RGD:1562986. rat.

Organism-specific databases

CTDi 27302.
RGDi 1562986. Bmp10.

Phylogenomic databases

eggNOGi NOG280573.
GeneTreei ENSGT00760000118883.
HOGENOMi HOG000249477.
HOVERGENi HBG106648.
InParanoidi Q4AEG6.
KOi K05503.
OMAi NVSIPHH.
OrthoDBi EOG7ZD1V3.
PhylomeDBi Q4AEG6.
TreeFami TF316134.

Enzyme and pathway databases

Reactomei REACT_198592. Molecules associated with elastic fibres.

Miscellaneous databases

NextBioi 705556.
PROi Q4AEG6.

Gene expression databases

Genevestigatori Q4AEG6.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines."
    Tsuji A.B., Sugyo A., Ogiu T., Sagara M., Kimura T., Ishikawa A., Sudo H., Ohtsuki M., Aburatani H., Imai T., Harada Y.N.
    Genomics 86:271-279(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344/DuCrjImported and LEC/CrjImported.

Entry informationi

Entry nameiBMP10_RAT
AccessioniPrimary (citable) accession number: Q4AEG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not appear to contribute to radiation susceptibility in the LEC strain.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3