Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4AEG6 (BMP10_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 10

Short name=BMP-10
Gene names
Name:Bmp10
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines By similarity. UniProtKB Q9R229 UniProtKB O95393

Subunit structure

Homodimer; disulfide-linked By similarity. UniProtKB P12643

Subcellular location

Secreted By similarity UniProtKB P12643.

Miscellaneous

Does not appear to contribute to radiation susceptibility in the LEC strain. Ref.1

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

activin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

adult heart development

Inferred from electronic annotation. Source: Ensembl

atrial cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

cell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

heart trabecula formation

Inferred from electronic annotation. Source: Ensembl

negative regulation of cardiac muscle hypertrophy

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardiac muscle hypertrophy

Inferred from mutant phenotype PubMed 17921333. Source: BHF-UCL

positive regulation of cell proliferation involved in heart morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of sarcomere organization

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

regulation of cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

sarcomere organization

Inferred from mutant phenotype PubMed 17921333. Source: BHF-UCL

ventricular cardiac muscle cell development

Inferred from electronic annotation. Source: Ensembl

ventricular cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentZ disc

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 313292 Potential
PRO_0000310575
Chain314 – 421108Bone morphogenetic protein 10
PRO_0000310576

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation1311N-linked (GlcNAc...) Potential
Disulfide bond320 ↔ 386 By similarity UniProtKB P12643
Disulfide bond349 ↔ 418 By similarity UniProtKB P12643
Disulfide bond353 ↔ 420 By similarity UniProtKB P12643
Disulfide bond385Interchain By similarity UniProtKB P12643

Sequences

Sequence LengthMass (Da)Tools
Q4AEG6 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 94E1496B7BEDFD36

FASTA42147,767
        10         20         30         40         50         60 
MGSLVLPLSA VFCLVARLAS GSPIMGLEQS PLEEDMPFFD DIFTEQDGID FNTLLQSMKD 

        70         80         90        100        110        120 
EFLKTLNLSD IPPQDTGRVD PPEYMLELYN KFATDRTSMP SANIIRSFKN EDLFSQPVSF 

       130        140        150        160        170        180 
NGIRKYPLLF NVSIPHHEEV VMAELRLYTL VQRDRLMYDG VDRKIIIFEV LESADGSEDE 

       190        200        210        220        230        240 
RSMLVLVSTE IYGTNSEWET FDITDATRRW QKSGPSTHQL EIHIESRQNQ AEDTGRGQLE 

       250        260        270        280        290        300 
IDMSAQNKHD PLLVVFSDDQ SGDKEQKEEL NELISHEQDL DLGTDGFFGG PDEEALLQMR 

       310        320        330        340        350        360 
SNMIDDSTAR IRRNAKGNYC KKTPLYIDFK EIGWDSWIIA PPGYEAYECR GVCNYPLAEH 

       370        380        390        400        410        420 
LTPTKHAIIQ ALVHLKNSQK ASKACCVPTK LDPISILYLD KGVVTYKFKY EGMAVSECGC 


R 

« Hide

References

[1]"Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines."
Tsuji A.B., Sugyo A., Ogiu T., Sagara M., Kimura T., Ishikawa A., Sudo H., Ohtsuki M., Aburatani H., Imai T., Harada Y.N.
Genomics 86:271-279(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Fischer 344/DuCrj and LEC/Crj.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB158417 mRNA. Translation: BAE16989.1.
AB158418 mRNA. Translation: BAE16990.1.
RefSeqNP_001026994.1. NM_001031824.1.
UniGeneRn.118010.

3D structure databases

ProteinModelPortalQ4AEG6.
SMRQ4AEG6. Positions 317-421.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012365.

Proteomic databases

PRIDEQ4AEG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000012365; ENSRNOP00000012365; ENSRNOG00000009316.
GeneID500245.
KEGGrno:500245.
UCSCRGD:1562986. rat.

Organism-specific databases

CTD27302.
RGD1562986. Bmp10.

Phylogenomic databases

eggNOGNOG280573.
GeneTreeENSGT00740000115456.
HOGENOMHOG000249477.
HOVERGENHBG106648.
InParanoidQ4AEG6.
KOK05503.
OMAYEAYECR.
OrthoDBEOG7ZD1V3.
PhylomeDBQ4AEG6.
TreeFamTF316134.

Gene expression databases

GenevestigatorQ4AEG6.

Family and domain databases

InterProIPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio705556.
PROQ4AEG6.

Entry information

Entry nameBMP10_RAT
AccessionPrimary (citable) accession number: Q4AEG6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 13, 2005
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families