Q4AEG6 (BMP10_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 10
Short name=BMP-10

Gene names

Name:

Bmp10

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth By similarity. UniProtKB Q9R229 UniProtKB O95393
Subunit structure	Homodimer; disulfide-linked By similarity. UniProtKB P12643
Subcellular location	Secreted By similarity UniProtKB P12643.
Miscellaneous	Does not appear to contribute to radiation susceptibility in the LEC strain. Ref.1
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from electronic annotation. Source: Compara activin receptor signaling pathway Inferred from electronic annotation. Source: Compara adult heart development Inferred from electronic annotation. Source: Compara atrial cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara cardiac muscle cell proliferation Inferred from electronic annotation. Source: Compara heart trabecula formation Inferred from electronic annotation. Source: Compara negative regulation of cardiac muscle hypertrophy Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of endothelial cell migration Inferred from electronic annotation. Source: Compara pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle hypertrophy Inferred from mutant phenotype PubMed 17921333. Source: BHF-UCL positive regulation of cell proliferation involved in heart morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of sarcomere organization Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of cardiac muscle contraction Inferred from electronic annotation. Source: Compara sarcomere organization Inferred from mutant phenotype PubMed 17921333. Source: BHF-UCL ventricular cardiac muscle cell development Inferred from electronic annotation. Source: Compara ventricular cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	Z disc Inferred from electronic annotation. Source: Compara cell surface Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 313	292	Potential		PRO_0000310575
	Chain	314 – 421	108	Bone morphogenetic protein 10		PRO_0000310576
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
	Disulfide bond	320 ↔ 386		By similarity UniProtKB P12643
	Disulfide bond	349 ↔ 418		By similarity UniProtKB P12643
	Disulfide bond	353 ↔ 420		By similarity UniProtKB P12643
	Disulfide bond	385		Interchain By similarity UniProtKB P12643

Sequences

	Sequence		Length	Mass (Da)
	Q4AEG6 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 94E1496B7BEDFD36	FASTA	421	47,767
	10 20 30 40 50 60 MGSLVLPLSA VFCLVARLAS GSPIMGLEQS PLEEDMPFFD DIFTEQDGID FNTLLQSMKD 70 80 90 100 110 120 EFLKTLNLSD IPPQDTGRVD PPEYMLELYN KFATDRTSMP SANIIRSFKN EDLFSQPVSF 130 140 150 160 170 180 NGIRKYPLLF NVSIPHHEEV VMAELRLYTL VQRDRLMYDG VDRKIIIFEV LESADGSEDE 190 200 210 220 230 240 RSMLVLVSTE IYGTNSEWET FDITDATRRW QKSGPSTHQL EIHIESRQNQ AEDTGRGQLE 250 260 270 280 290 300 IDMSAQNKHD PLLVVFSDDQ SGDKEQKEEL NELISHEQDL DLGTDGFFGG PDEEALLQMR 310 320 330 340 350 360 SNMIDDSTAR IRRNAKGNYC KKTPLYIDFK EIGWDSWIIA PPGYEAYECR GVCNYPLAEH 370 380 390 400 410 420 LTPTKHAIIQ ALVHLKNSQK ASKACCVPTK LDPISILYLD KGVVTYKFKY EGMAVSECGC R

References

[1]	"Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines." Tsuji A.B., Sugyo A., Ogiu T., Sagara M., Kimura T., Ishikawa A., Sudo H., Ohtsuki M., Aburatani H., Imai T., Harada Y.N. Genomics 86:271-279(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Fischer 344/DuCrj and LEC/Crj.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB158417 mRNA. Translation: BAE16989.1. AB158418 mRNA. Translation: BAE16990.1.
IPI	IPI00201685.
RefSeq	NP_001026994.1. NM_001031824.1.
UniGene	Rn.118010.
3D structure databases
HSSP	HSSP built from PDB template 2ARP based on UniProtKB P08476.
ProteinModelPortal	Q4AEG6.
SMR	Q4AEG6. Positions 317-421.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000012365.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000012365; ENSRNOP00000012365; ENSRNOG00000009316.
GeneID	500245.
KEGG	rno:500245.
UCSC	RGD:1562986. rat.
Organism-specific databases
CTD	27302.
RGD	1562986. Bmp10.
Phylogenomic databases
eggNOG	NOG280573.
GeneTree	ENSGT00620000087601.
HOGENOM	HOG000249477.
HOVERGEN	HBG106648.
InParanoid	Q4AEG6.
KO	K05503.
OMA	YEAYECR.
OrthoDB	EOG40GCQR.
Gene expression databases
Genevestigator	Q4AEG6.
Family and domain databases
InterPro	IPR002405. Inhibin_asu. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR00669. INHIBINA.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	705556.

Entry information

Entry name

BMP10_RAT

Accession

Primary (citable) accession number: Q4AEG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	September 13, 2005
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program