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Protein

Coatomer subunit gamma-1

Gene

Copg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • establishment of Golgi localization Source: BHF-UCL
  • intracellular protein transport Source: InterPro
  • organelle transport along microtubule Source: BHF-UCL
  • vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gamma-1
Alternative name(s):
Gamma-1-coat protein
Short name:
Gamma-1-COP
Gene namesi
Name:Copg1
Synonyms:Copg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1565292. Copg1.

Subcellular locationi

GO - Cellular componenti

  • COPI vesicle coat Source: InterPro
  • cytosol Source: UniProtKB-SubCell
  • Golgi membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049401 – 874Coatomer subunit gamma-1Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4AEF8.
PRIDEiQ4AEF8.

PTM databases

iPTMnetiQ4AEF8.
PhosphoSitePlusiQ4AEF8.
SwissPalmiQ4AEF8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010474.
ExpressionAtlasiQ4AEF8. baseline and differential.
GenevisibleiQ4AEF8. RN.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain (By similarity). Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER (By similarity). Interacts with COPB1 (By similarity). Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9 (By similarity).By similarity

Protein-protein interaction databases

BioGridi255579. 2 interactors.
IntActiQ4AEF8. 2 interactors.
STRINGi10116.ENSRNOP00000016137.

Structurei

3D structure databases

ProteinModelPortaliQ4AEF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 101HEAT 1Add BLAST38
Repeati283 – 320HEAT 2Add BLAST38
Repeati322 – 355HEAT 3Add BLAST34
Repeati356 – 392HEAT 4Add BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni609 – 874Interaction with ZNF289/ARFGAP2By similarityAdd BLAST266

Sequence similaritiesi

Belongs to the COPG family.Curated
Contains 4 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1078. Eukaryota.
COG5240. LUCA.
GeneTreeiENSGT00390000016313.
HOGENOMiHOG000184434.
HOVERGENiHBG004368.
InParanoidiQ4AEF8.
KOiK17267.
PhylomeDBiQ4AEF8.
TreeFamiTF300324.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR032154. Coatomer_g_Cpla.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERiPTHR10261. PTHR10261. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF16381. Coatomer_g_Cpla. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4AEF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKFDKKDE ESGGGSNPLQ HLEKSAVLQE ARVFNETPIN PRKCAHILTK
60 70 80 90 100
ILYLINQGEH LGTTEATEAF FAMTKLFQSN DPTLRRMCYL TIKEMSCIAE
110 120 130 140 150
DVIIVTSSLT KDMTGKEDNY RGPAVRALCQ ITDSTMLQAV ERYMKQAIVD
160 170 180 190 200
KVPSVSSSAL VSSLHLLKCS FDVVKRWVNE AQEAASSDNI MVQYHALGLL
210 220 230 240 250
YHVRKNDRLA VSKMISKFTR HGLKSPFAYC MMIRVASKQL EEEDGSRDSP
260 270 280 290 300
LFDFIESCLR NKHEMVVYEA ASAIVNLPGC SAKELAPAVS VLQLFCSSPK
310 320 330 340 350
AALRYAAVRT LNKVAMKHPS AVTACNLDLE NLVTDSNRSI ATLAITTLLK
360 370 380 390 400
TGSESSIDRL MKQISSFMSE ISDEFKVVVV QAISALCQKY PRKHAVLMNF
410 420 430 440 450
LFTMLREEGG FEYKRAIVDC IISIIEENSE SKETGLSHLC EFIEDCEFTV
460 470 480 490 500
LATRILHLLG QEGPKTNNPS KYIRFIYNRV VLEHEEVRAG AVSALAKFGA
510 520 530 540 550
QNEEMLPSIL VLLKRCVMDD DNEVRDRATF YLNVLEQKQK ALNAGYILNG
560 570 580 590 600
LTVSIPGLEK ALQQYTLEPS EKPFDLKSVP LATTPMTEQR PESTSTAAVK
610 620 630 640 650
QPEKVAATRQ EIFQEQLAAV PEFQGLGPLF KSSPEPVALT ESETEYVIRC
660 670 680 690 700
TKHTFSDHLV FQFDCTNTLN DQTLENVTVQ MEPTEAYEVL SYVPVRSLPY
710 720 730 740 750
NQPGTCYTLV ALPKEDPTAV ACTFSCVMKF TVKDCDPNTG EIDEEGYEDE
760 770 780 790 800
YVLEDLEVTV ADHIQKVMKV NFEAAWDEVG DEFEKEETFT LSTIKTLEEA
810 820 830 840 850
VGNIVKFLGM HPCERSDKVP ENKNTHTLLL AGVFRGGHDI LVRSRLLLLD
860 870
TVTMQVTARS SEELPVDIIL ASVG
Length:874
Mass (Da):97,614
Last modified:September 13, 2005 - v1
Checksum:iA4C2AD19A74E7D63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB158425 mRNA. Translation: BAE16997.1.
AB158426 mRNA. Translation: BAE16998.1.
BC129074 mRNA. Translation: AAI29075.1.
RefSeqiNP_001026992.1. NM_001031822.3.
UniGeneiRn.50150.

Genome annotation databases

EnsembliENSRNOT00000016137; ENSRNOP00000016137; ENSRNOG00000010474.
GeneIDi297428.
KEGGirno:297428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB158425 mRNA. Translation: BAE16997.1.
AB158426 mRNA. Translation: BAE16998.1.
BC129074 mRNA. Translation: AAI29075.1.
RefSeqiNP_001026992.1. NM_001031822.3.
UniGeneiRn.50150.

3D structure databases

ProteinModelPortaliQ4AEF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi255579. 2 interactors.
IntActiQ4AEF8. 2 interactors.
STRINGi10116.ENSRNOP00000016137.

PTM databases

iPTMnetiQ4AEF8.
PhosphoSitePlusiQ4AEF8.
SwissPalmiQ4AEF8.

Proteomic databases

PaxDbiQ4AEF8.
PRIDEiQ4AEF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016137; ENSRNOP00000016137; ENSRNOG00000010474.
GeneIDi297428.
KEGGirno:297428.

Organism-specific databases

CTDi22820.
RGDi1565292. Copg1.

Phylogenomic databases

eggNOGiKOG1078. Eukaryota.
COG5240. LUCA.
GeneTreeiENSGT00390000016313.
HOGENOMiHOG000184434.
HOVERGENiHBG004368.
InParanoidiQ4AEF8.
KOiK17267.
PhylomeDBiQ4AEF8.
TreeFamiTF300324.

Enzyme and pathway databases

ReactomeiR-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ4AEF8.

Gene expression databases

BgeeiENSRNOG00000010474.
ExpressionAtlasiQ4AEF8. baseline and differential.
GenevisibleiQ4AEF8. RN.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR032154. Coatomer_g_Cpla.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERiPTHR10261. PTHR10261. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF16381. Coatomer_g_Cpla. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOPG1_RAT
AccessioniPrimary (citable) accession number: Q4AEF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.