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Protein
Submitted name:

Methanol dehydrogenase large subunit

Gene

moxF

Organism
Hyphomicrobium denitrificans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi177 – 1771CalciumCombined sources
Metal bindingi261 – 2611CalciumCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Methanol dehydrogenase large subunitImported
Gene namesi
Name:moxFImported
OrganismiHyphomicrobium denitrificansImported
Taxonomic identifieri53399 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeHyphomicrobium

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 104Combined sources
Disulfide bondi386 ↔ 415Combined sources

Interactioni

Protein-protein interaction databases

STRINGi582899.Hden_1323.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D0VX-ray2.49A/D/I1-597[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4AE26.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG41089S2. Bacteria.
COG4993. LUCA.

Family and domain databases

Gene3Di2.140.10.10. 1 hit.
InterProiIPR018391. PQQ_beta_propeller_repeat.
IPR017512. PQQ_MeOH/EtOH_DH.
IPR002372. PQQ_repeat.
IPR027295. Quinoprotein_ADH-like_fam.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR001479. Quinoprotein_DH_CS.
[Graphical view]
PfamiPF01011. PQQ. 2 hits.
PF13360. PQQ_2. 1 hit.
[Graphical view]
SMARTiSM00564. PQQ. 3 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 1 hit.
TIGRFAMsiTIGR03075. PQQ_enz_alc_DH. 1 hit.
PROSITEiPS00363. BACTERIAL_PQQ_1. 1 hit.
PS00364. BACTERIAL_PQQ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4AE26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NDKLIELSNS NENWVMPGKN YDSNNYSTST QINVDNVKQL KHAWSFSTGE
60 70 80 90 100
LHGHEGAPLV IGDVMYVHSS FPNKTFALDL NDPGHILWQH SPKQDPAARS
110 120 130 140 150
VACCDLVNRG LAYWPGDDKT PSLIIKTQLD GHLVALNAKT GEEFWKVENG
160 170 180 190 200
DIKVGQTLTQ APYVVHDLAI VGSSGAELGV RGHVTAYNVR TGEQAWRYYA
210 220 230 240 250
TGPDAEIGLA DDFNSANPHY GQKGLGTATW EGDAWKIGGG TNWGWYAYDP
260 270 280 290 300
AANLIYYGSG NPAPWNETMR PGDNKWTMTI TARDADTGKM KFGYQKTPHD
310 320 330 340 350
EWDFAGVNVI MLSEQTDKTG KKRKLLTHPD RNGIVYTLDR ENGDLISADK
360 370 380 390 400
LDDTVNVFKT VDLKTGLPVR DPEYGTRMDH KGTDICPSAM GYHNQGHDSY
410 420 430 440 450
DPQKQLFFMG INHICMDWEP FMLPYRAGQF FVGATLWMYP GPKGDRQNYL
460 470 480 490 500
GLGQIKAYNA ITNEYKWQHM ERFSVWGGTL ATAGNLVFYG TLDGFLKARN
510 520 530 540 550
SDTGELVWKH KLPSGVIGYP MTYEHKGVQY IAVMSGVGGW PGVGLVFDLQ
560 570 580 590
DPTAGLGAVG AFKNLQNYTQ MGGSLEVFSL DGKNPYDDVN VGEYEKG
Length:597
Mass (Da):66,103
Last modified:September 13, 2005 - v1
Checksum:i3A3B0D6F5BA98A2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB201477 Genomic DNA. Translation: BAE16958.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB201477 Genomic DNA. Translation: BAE16958.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D0VX-ray2.49A/D/I1-597[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi582899.Hden_1323.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG41089S2. Bacteria.
COG4993. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ4AE26.

Family and domain databases

Gene3Di2.140.10.10. 1 hit.
InterProiIPR018391. PQQ_beta_propeller_repeat.
IPR017512. PQQ_MeOH/EtOH_DH.
IPR002372. PQQ_repeat.
IPR027295. Quinoprotein_ADH-like_fam.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR001479. Quinoprotein_DH_CS.
[Graphical view]
PfamiPF01011. PQQ. 2 hits.
PF13360. PQQ_2. 1 hit.
[Graphical view]
SMARTiSM00564. PQQ. 3 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 1 hit.
TIGRFAMsiTIGR03075. PQQ_enz_alc_DH. 1 hit.
PROSITEiPS00363. BACTERIAL_PQQ_1. 1 hit.
PS00364. BACTERIAL_PQQ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization and Molecular Cloning of Methanol Dehydrogenase from Hyphomicrobium denitrificans A3151."
    Nojiri M., Hira D., Yamaguchi K., Suzuki S.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A3151Imported.
  2. "Crystal structures of cytochrome c(L) and methanol dehydrogenase from Hyphomicrobium denitrificans: structural and mechanistic insights into interactions between the two proteins."
    Nojiri M., Hira D., Yamaguchi K., Okajima T., Tanizawa K., Suzuki S.
    Biochemistry 45:3481-3492(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS) IN COMPLEX WITH CALCIUM, DISULFIDE BONDS.

Entry informationi

Entry nameiQ4AE26_9RHIZ
AccessioniPrimary (citable) accession number: Q4AE26
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 16, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.