ID   CFI2_FRAAN              Reviewed;         237 AA.
AC   Q4AE12;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 17.
DE   RecName: Full=Chalcone--flavonone isomerase 2;
DE            Short=Chalcone isomerase 2;
DE            EC=5.5.1.6;
GN   Name=CHI2; Synonyms=FrCHI17;
OS   Fragaria ananassa (Strawberry).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids I; Rosales; Rosaceae; Rosoideae; Fragaria.
OX   NCBI_TaxID=3747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Sachinoka; TISSUE=Fruit cortical tissue;
RA   Adachi Y., Chiba N., Suzuki G., Kano H., Nakamura S.;
RT   "Genes regulating anthocyanin-synthesis pathway in white wild
RT   strawberry.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the intramolecular cyclization of bicyclic
CC       chalcones into tricyclic (S)-flavanones. Responsible for the
CC       isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed
CC       chalcone) into naringenin (By similarity).
CC   -!- CATALYTIC ACTIVITY: A chalcone = a flavanone.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid
CC       biosynthesis.
CC   -!- MISCELLANEOUS: Part of the biosynthetic pathway for all classes of
CC       flavonoids, a large class of secondary plant metabolites, many of
CC       which are brightly colored.
CC   -!- SIMILARITY: Belongs to the chalcone isomerase family.
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DR   EMBL; AB201754; BAE17120.1; -; mRNA.
DR   BRENDA; 5.5.1.6; 275939.
DR   GO; GO:0045430; F:chalcone isomerase activity; IEA:EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016088; Chalcone_isomerase_3-sand.
DR   InterPro; IPR003466; Chalcone_isomerase_subgr.
DR   Gene3D; G3DSA:3.50.70.10; Chalcone; 1.
DR   Pfam; PF02431; Chalcone; 1.
PE   2: Evidence at transcript level;
KW   Flavonoid biosynthesis; Isomerase.
FT   CHAIN         1    237       Chalcone--flavonone isomerase 2.
FT                                /FTId=PRO_0000300837.
FT   BINDING      48     48       Substrate (By similarity).
FT   BINDING     113    113       Substrate (By similarity).
FT   BINDING     190    190       Substrate (By similarity).
FT   SITE        106    106       Important for catalytic activity (By
FT                                similarity).
SQ   SEQUENCE   237 AA;  25468 MW;  F1E5838A3F189B34 CRC64;
     MAQSVTGIQI GGTSFPPAVK PPGSGNTLFL GGAGVRGMEI QGNFVKFTAI GVYLEDKAVP
     ALSVKWKGKT AEELTESVEF FREIVTGPFE KFTQVTMILP LTGQQYSEKV SENCVAIWKK
     FGIYTDAEAK AIEKFIEVFK DQTFPPGASI LFTQSPNGSL MIGISKDGSI PEVGNAVIEN
     KLLSESVLES IIGKQGVSPE ARKSVATRLS ELLKESDHCV AGNEKVDECT KEAENKA
//