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Protein

RAB6A-GEF complex partner protein 1

Gene

RIC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.2 Publications

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB
  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • negative regulation of cellular protein catabolic process Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: UniProtKB

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
RAB6A-GEF complex partner protein 1Imported
Alternative name(s):
Connexin-43-interacting protein of 150 kDa
Protein RIC1 homologBy similarity
Gene namesi
Name:RIC1Imported
Synonyms:CIP150, KIAA1432
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107036.11
HGNCiHGNC:17686 RIC1
MIMi610354 gene
neXtProtiNX_Q4ADV7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1267 – 1287HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57589
OpenTargetsiENSG00000107036
PharmGKBiPA134884486

Polymorphism and mutation databases

BioMutaiKIAA1432
DMDMi182702127

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206621 – 1423RAB6A-GEF complex partner protein 1Add BLAST1423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei992PhosphothreonineCombined sources1
Modified residuei996PhosphothreonineCombined sources1
Modified residuei1015PhosphoserineCombined sources1
Modified residuei1017PhosphoserineCombined sources1
Modified residuei1019PhosphoserineCombined sources1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1172PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ4ADV7
MaxQBiQ4ADV7
PaxDbiQ4ADV7
PeptideAtlasiQ4ADV7
PRIDEiQ4ADV7

PTM databases

iPTMnetiQ4ADV7
PhosphoSitePlusiQ4ADV7

Expressioni

Tissue specificityi

Present in kidney and various cell lines (at protein level). Widely expressed at low level.2 Publications

Gene expression databases

BgeeiENSG00000107036
CleanExiHS_KIAA1432
ExpressionAtlasiQ4ADV7 baseline and differential
GenevisibleiQ4ADV7 HS

Organism-specific databases

HPAiHPA051578

Interactioni

Subunit structurei

Forms a complex with RGP1; the interaction enhances RAB6A GTPase activity. Interacts (via central domain) with RGP1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts (via C-terminus domain) with RAB33B; the interaction is direct with a preference for RAB33B-GTP. Interacts with GJA1.2 Publications

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB
  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi121640, 6 interactors
IntActiQ4ADV7, 2 interactors
MINTiQ4ADV7
STRINGi9606.ENSP00000416696

Structurei

3D structure databases

ProteinModelPortaliQ4ADV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 103WD 1Add BLAST40
Repeati304 – 343WD 2Add BLAST40

Sequence similaritiesi

Belongs to the RIC1 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, WD repeat

Phylogenomic databases

eggNOGiKOG2006 Eukaryota
ENOG410XT5J LUCA
GeneTreeiENSGT00390000002955
HOGENOMiHOG000047604
HOVERGENiHBG091027
InParanoidiQ4ADV7
KOiK20476
OMAiWRPDSTM
OrthoDBiEOG091G00MD
PhylomeDBiQ4ADV7
TreeFamiTF105927

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR009771 Ribosome_control_1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF07064 RIC1, 1 hit
SUPFAMiSSF50978 SSF50978, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4ADV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYFLSGWPKR LLCPLGSPAE APFHVQSDPQ RAFFAVLAAA RLSIWYSRPS
60 70 80 90 100
VLIVTYKEPA KSSTQFGSYK QAEWRPDSTM IAVSTANGYI LFFHITSTRG
110 120 130 140 150
DKYLYEPVYP KGSPQMKGTP HFKEEQCAPA LNLEMRKILD LQAPIMSLQS
160 170 180 190 200
VLEDLLVATS DGLLHLIHWE GMTNGRKAIN LCTVPFSVDL QSSRVGSFLG
210 220 230 240 250
FTDVHIRDME YCATLDGFAV VFNDGKVGFI TPVSSRFTAE QLHGVWPQDV
260 270 280 290 300
VDGTCVAVNN KYRLMAFGCV SGSVQVYTID NSTGAMLLSH KLELTAKQYP
310 320 330 340 350
DIWNKTGAVK LMRWSPDNSV VIVTWEYGGL SLWSVFGAQL ICTLGGDFAY
360 370 380 390 400
RSDGTKKDPL KINSMSWGAE GYHLWVISGF GSQNTEIESD LRSVVKQPSI
410 420 430 440 450
LLFQFIKSVL TVNPCMSNQE QVLLQGEDRL YLNCGEASQT QNPRSSSTHS
460 470 480 490 500
EHKPSREKSP FADGGLESQG LSTLLGHRHW HVVQISSTYL ESNWPIRFSA
510 520 530 540 550
IDKLGQNIAV VGKFGFAHYS LLTKKWKLFG NITQEQNMIV TGGLAWWNDF
560 570 580 590 600
MVLACYNIND RQEELRVYLR TSNLDNAFAH VTKAQAETLL LSVFQDMVIV
610 620 630 640 650
FRADCSICLY SIERKSDGPN TTAGIQVLQE VSMSRYIPHP FLVVSVTLTS
660 670 680 690 700
VSTENGITLK MPQQARGAES IMLNLAGQLI MMQRDRSGPQ IREKDSNPNN
710 720 730 740 750
QRKLLPFCPP VVLAQSVENV WTTCRANKQK RHLLEALWLS CGGAGMKVWL
760 770 780 790 800
PLFPRDHRKP HSFLSQRIML PFHINIYPLA VLFEDALVLG AVNDTLLYDS
810 820 830 840 850
LYTRNNAREQ LEVLFPFCVV ERTSQIYLHH ILRQLLVRNL GEQALLLAQS
860 870 880 890 900
CATLPYFPHV LELMLHEVLE EEATSREPIP DPLLPTVAKF ITEFPLFLQT
910 920 930 940 950
VVHCARKTEY ALWNYLFAAV GNPKDLFEEC LMAQDLDTAA SYLIILQNME
960 970 980 990 1000
VPAVSRQHAT LLFNTALEQG KWDLCRHMIR FLKAIGSGES ETPPSTPTAQ
1010 1020 1030 1040 1050
EPSSSGGFEF FRNRSISLSQ SAENVPASKF SLQKTLSMPS GPSGKRWSKD
1060 1070 1080 1090 1100
SDCAENMYID MMLWRHARRL LEDVRLKDLG CFAAQLGFEL ISWLCKERTR
1110 1120 1130 1140 1150
AARVDNFVIA LKRLHKDFLW PLPIIPASSI SSPFKNGKYR TVGEQLLKSQ
1160 1170 1180 1190 1200
SADPFLNLEM DAGISNIQRS QSWLSNIGPT HHEIDTASSH GPQMQDAFLS
1210 1220 1230 1240 1250
PLSNKGDECS IGSATDLTES SSMVDGDWTM VDENFSTLSL TQSELEHISM
1260 1270 1280 1290 1300
ELASKGPHKS QVQLRYLLHI FMEAGCLDWC IVIGLILRES SIINQILVIT
1310 1320 1330 1340 1350
QSSEVDGEML QNIKTGLHAV DRWASTDCPG YKPFLNIIKP QLQKLSEITE
1360 1370 1380 1390 1400
EQVQPDAFQP ITMGKTPEQT SPRAEESRGS SSHGSIPQGE VGSSNMVSRK
1410 1420
EEDTAQAEEE EPFQDGTYDC SVS
Length:1,423
Mass (Da):159,301
Last modified:February 26, 2008 - v2
Checksum:i9F6F43F572021930
GO
Isoform 2 (identifier: Q4ADV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1142-1165: VGEQLLKSQSADPFLNLEMDAGIS → GNVDFMSLVQGELYFTPCIYTFCY
     1166-1423: Missing.

Note: No experimental confirmation available.
Show »
Length:1,165
Mass (Da):131,167
Checksum:iFCEA626180A59C3E
GO
Isoform 3 (identifier: Q4ADV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     498-534: Missing.

Note: No experimental confirmation available.
Show »
Length:1,386
Mass (Da):155,177
Checksum:i9EAA63EE7FCDFDA9
GO

Sequence cautioni

The sequence AAI36617 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI44297 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14150 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE16982 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB66809 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI95003 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95004 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti659L → F in BAB84976 (PubMed:10718198).Curated1
Sequence conflicti664Q → E in BAB84976 (PubMed:10718198).Curated1
Sequence conflicti1012R → G in AAH30576 (PubMed:12168954).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042408498 – 534Missing in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_0317061142 – 1165VGEQL…DAGIS → GNVDFMSLVQGELYFTPCIY TFCY in isoform 2. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_0317071166 – 1423Missing in isoform 2. 2 PublicationsAdd BLAST258

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136980 Genomic DNA Translation: CAI95003.1 Sequence problems.
AL136980 Genomic DNA Translation: CAI95004.1 Sequence problems.
AL354744 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58760.1
AL136875 mRNA Translation: CAB66809.1 Different initiation.
AB205401 mRNA Translation: BAE16982.1 Different initiation.
AK022642 mRNA Translation: BAB14150.1 Different initiation.
AB037853 mRNA Translation: BAA92670.2
AK074150 mRNA Translation: BAB84976.1
BC030576 mRNA Translation: AAH30576.1
BC136616 mRNA Translation: AAI36617.1 Different initiation.
BC144296 mRNA Translation: AAI44297.1 Different initiation.
CCDSiCCDS34982.2 [Q4ADV7-1]
CCDS47949.2 [Q4ADV7-2]
CCDS75811.1 [Q4ADV7-3]
RefSeqiNP_001129392.2, NM_001135920.2 [Q4ADV7-2]
NP_001193486.1, NM_001206557.1 [Q4ADV7-3]
NP_065880.2, NM_020829.3 [Q4ADV7-1]
UniGeneiHs.211520
Hs.661509

Genome annotation databases

EnsembliENST00000251879; ENSP00000251879; ENSG00000107036 [Q4ADV7-2]
ENST00000414202; ENSP00000416696; ENSG00000107036 [Q4ADV7-1]
ENST00000418622; ENSP00000402240; ENSG00000107036 [Q4ADV7-3]
GeneIDi57589
KEGGihsa:57589
UCSCiuc003zjh.5 human [Q4ADV7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRIC1_HUMAN
AccessioniPrimary (citable) accession number: Q4ADV7
Secondary accession number(s): B2RN24
, B7ZM67, G5E932, Q4VXJ8, Q4VXJ9, Q76MT5, Q8N6E0, Q8TEH4, Q9H0A5, Q9H9S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 25, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health