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Protein
Submitted name:

HCG1991317, isoform CRA_b

Gene

TWEAK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HCG1991317, isoform CRA_bImported
Submitted name:
TWEAKImported
Submitted name:
Tumor necrosis factor (Ligand) superfamily, member 12Imported
Gene namesi
Name:TWEAKImported
Synonyms:TNFSF12Imported
ORF Names:hCG_1991317Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36620.

Expressioni

Gene expression databases

BgeeiENSG00000239697.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000451451.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 248TNF_2InterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Phylogenomic databases

eggNOGiENOG410II60. Eukaryota.
ENOG410Y4KC. LUCA.
HOVERGENiHBG055510.
KOiK05474.
OMAiNPLRYDC.
OrthoDBiEOG091G0MIB.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ACW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL
60 70 80 90 100
SAQEPAQEEL VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK
110 120 130 140 150
TRARRAIAAH YEVHPRPGQD GAQAGVDGTV SGWEEARINS SSPLRYNRQI
160 170 180 190 200
GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD LLVDGVLALR CLEEFSATAA
210 220 230 240
SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL TYFGLFQVH
Length:249
Mass (Da):27,216
Last modified:September 13, 2005 - v1
Checksum:iE660843361C28EBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104420 mRNA. Translation: AAI04421.1.
AB222993 Genomic DNA. Translation: BAE16557.1.
CH471108 Genomic DNA. Translation: EAW90179.1.
RefSeqiNP_003800.1. NM_003809.2.
UniGeneiHs.54673.

Genome annotation databases

GeneIDi8742.
KEGGihsa:8742.
UCSCiuc002ghg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104420 mRNA. Translation: AAI04421.1.
AB222993 Genomic DNA. Translation: BAE16557.1.
CH471108 Genomic DNA. Translation: EAW90179.1.
RefSeqiNP_003800.1. NM_003809.2.
UniGeneiHs.54673.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000451451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8742.
KEGGihsa:8742.
UCSCiuc002ghg.4. human.

Organism-specific databases

CTDi8742.
PharmGKBiPA36620.

Phylogenomic databases

eggNOGiENOG410II60. Eukaryota.
ENOG410Y4KC. LUCA.
HOVERGENiHBG055510.
KOiK05474.
OMAiNPLRYDC.
OrthoDBiEOG091G0MIB.

Miscellaneous databases

GenomeRNAii8742.

Gene expression databases

BgeeiENSG00000239697.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4ACW9_HUMAN
AccessioniPrimary (citable) accession number: Q4ACW9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 5, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.