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Protein
Submitted name:

HCG1991317, isoform CRA_b

Gene

TWEAK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
HCG1991317, isoform CRA_bImported
Submitted name:
TWEAKImported
Submitted name:
Tumor necrosis factor (Ligand) superfamily, member 12Imported
Gene namesi
Name:TWEAKImported
Synonyms:TNFSF12Imported
ORF Names:hCG_1991317Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000239697.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36620

Expressioni

Gene expression databases

BgeeiENSG00000239697
ExpressionAtlasiQ4ACW9 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DDIT3P35638-23EBI-10241785,EBI-10173632

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ4ACW9, 1 interactor

Structurei

3D structure databases

SMRiQ4ACW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 248TNF_2InterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Phylogenomic databases

eggNOGiENOG410II60 Eukaryota
ENOG410Y4KC LUCA
HOVERGENiHBG055510
KOiK05474
OMAiTAWTWRQ
OrthoDBiEOG091G0MIB

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4ACW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL
60 70 80 90 100
SAQEPAQEEL VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK
110 120 130 140 150
TRARRAIAAH YEVHPRPGQD GAQAGVDGTV SGWEEARINS SSPLRYNRQI
160 170 180 190 200
GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD LLVDGVLALR CLEEFSATAA
210 220 230 240
SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL TYFGLFQVH
Length:249
Mass (Da):27,216
Last modified:September 13, 2005 - v1
Checksum:iE660843361C28EBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104420 mRNA Translation: AAI04421.1
AB222993 Genomic DNA Translation: BAE16557.1
CH471108 Genomic DNA Translation: EAW90179.1
RefSeqiNP_003800.1, NM_003809.2
UniGeneiHs.54673

Genome annotation databases

GeneIDi8742
KEGGihsa:8742
UCSCiuc002ghg.4 human

Similar proteinsi

Entry informationi

Entry nameiQ4ACW9_HUMAN
AccessioniPrimary (citable) accession number: Q4ACW9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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