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Protein

Angiotensin-converting enzyme

Gene

tACE

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPSiM02.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
Gene namesi
Name:tACEImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei699 – 720HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3432.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500423541923 – 745Angiotensin-converting enzymeSequence analysisAdd BLAST723

Keywords - PTMi

GlycoproteinUniRule annotation

Proteomic databases

PaxDbiQ4ACT8.
PRIDEiQ4ACT8.

Expressioni

Gene expression databases

GenevisibleiQ4ACT8. SS.

Structurei

3D structure databases

ProteinModelPortaliQ4ACT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3690. Eukaryota.
ENOG410XPJ3. LUCA.
HOGENOMiHOG000292210.
HOVERGENiHBG103676.
KOiK01283.

Family and domain databases

CDDicd06461. M2_ACE. 1 hit.
InterProiView protein in InterPro
IPR001548. Peptidase_M2.
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiView protein in Pfam
PF01401. Peptidase_M2. 1 hit.
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

Q4ACT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQGWAAPGL PCLLLLLLLC CGRPLLVPGQ GTTSQVTDIQ RTTSQATTSG
60 70 80 90 100
QATTSSQATT SSQTTTSHST TSSLKTQSPN LVSDEAEASK FVEEYDRRSQ
110 120 130 140 150
VVLNEYAEAN WDYNTNITAE GSKRVLEKST QMANHTVKYG IWARKFDVAN
160 170 180 190 200
IQNFTLKRMI KKIQDLERAA LPFKELEEYN QILLDMETAY SVASVCHANS
210 220 230 240 250
TCLQLEPDLT NLMDTSRSYE ELLWAWKGWR DKVGRAILPL FPKYVELTNK
260 270 280 290 300
AARLNGYEDG GDAWRAAYEM PFLEQELEQL FQELQPLYLN LHAYVRRALH
310 320 330 340 350
HHYGPEHINL EGPIPAHLLG NMWAQTWSNI YDLVVPFPSA SKMDASEAMI
360 370 380 390 400
NQGWTPQKMF KEADNFFTSL GLLPVPPEFW NKSMLEKPTD GREVVCHASA
410 420 430 440 450
WDFFNGKDFR IKQCTTVNME DLVVAHHEMG HIQYFMQYKD LPVTFREGAN
460 470 480 490 500
PGFHEAIGDV LALSVSTPKH LRSINLLKSE DDGYEEDINF LMKMALDKVA
510 520 530 540 550
FVPFSYLVDQ WRWRVFDRSI TKENYNQEWW SLRLKYQGLC PPVARSQGDF
560 570 580 590 600
DPGAKFHIPS SVPYIRYFVS FIIQFQFHEA LCQAAGHKGP LHKCDIYQSK
610 620 630 640 650
EAGRRLADAM KLGLSKPWPE AMQLITGQPN VSASAMMTYF KPLLDWLVTE
660 670 680 690 700
NGRHGEKLGW PQYNWTPNSA RLEGSFAGTG RVNFLGLNLE EQQARVGQWV
710 720 730 740
LLFLGVTLLV ATMGLTQRLF SIRHQILRRT HRGPQFGSEV ELRHS
Length:745
Mass (Da):84,801
Last modified:November 8, 2005 - v2
Checksum:i98C5784DAB9FC4B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB231334 mRNA. Translation: BAE16967.2.
UniGeneiSsc.25769.

Genome annotation databases

KEGGissc:613133.

Similar proteinsi

Entry informationi

Entry nameiQ4ACT8_PIG
AccessioniPrimary (citable) accession number: Q4ACT8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: November 8, 2005
Last modified: August 30, 2017
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)