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Q4AC99 (1A1L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2

Short name=ACC synthase-like protein 2
Gene names
Name:ACCSL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Caution

While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number of residues which are necessary for activity thus suggesting that it lacks enzymatic activity.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   LigandPyridoxal phosphate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbiosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
PRO_0000337057

Amino acid modifications

Modified residue3951N6-(pyridoxal phosphate)lysine By similarity

Natural variations

Natural variant5291C → R. Ref.1
Corresponds to variant rs2074051 [ dbSNP | Ensembl ].
VAR_060626

Experimental info

Sequence conflict1921S → R in BAE17132. Ref.1
Sequence conflict2721F → S in BAE17132. Ref.1
Sequence conflict2761L → P in BAE17132. Ref.1
Sequence conflict3111L → P in BAE17132. Ref.1
Sequence conflict4341K → E in BAE17132. Ref.1
Sequence conflict4541C → R in BAE17132. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q4AC99 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 233FC638E76AC393

FASTA56865,249
        10         20         30         40         50         60 
MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR QGLSLEERRH 

        70         80         90        100        110        120 
TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED SRGDVRYGQR AQLSGQPDPV 

       130        140        150        160        170        180 
PQLSDCEAAF VNRDLSIRGI DISVFYQSSF QDYNAYQKDK YHKDKNTLGF INLGTSENKL 

       190        200        210        220        230        240 
CMDLMTERLQ ESDMNCIEDT LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN 

       250        260        270        280        290        300 
GCCSVFCALA MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ 

       310        320        330        340        350        360 
LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR YNLHVIIDEI 

       370        380        390        400        410        420 
YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS GFRFGALYTH NKEVASAVSA 

       430        440        450        460        470        480 
FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL PTNCYRLREA HKYITAELKA LEIPFHNRSS 

       490        500        510        520        530        540 
GLYVWINLKK YLDPCTFEEE RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK 

       550        560 
LAMRRFCDVL QEQKEALIVK QLEDAMRE 

« Hide

References

[1]"Identification of novel human genes predicted by combining multiple gene-finders."
Totoki Y., Yada T., Sakaki Y., Takeda T.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-529.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB231734 mRNA. Translation: BAE17132.1.
AC134775 Genomic DNA. No translation available.
RefSeqNP_001027025.2. NM_001031854.2.
UniGeneHs.558851.

3D structure databases

ProteinModelPortalQ4AC99.
SMRQ4AC99. Positions 135-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000368109.

PTM databases

PhosphoSiteQ4AC99.

Polymorphism databases

DMDM296439453.

Proteomic databases

PaxDbQ4AC99.
PRIDEQ4AC99.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378832; ENSP00000368109; ENSG00000205126.
GeneID390110.
KEGGhsa:390110.
UCSCuc001mxw.1. human.

Organism-specific databases

CTD390110.
GeneCardsGC11P044027.
HGNCHGNC:34391. ACCSL.
HPAHPA046163.
neXtProtNX_Q4AC99.
PharmGKBPA164714805.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0436.
HOGENOMHOG000033689.
HOVERGENHBG055243.
InParanoidQ4AC99.
OMAQNTEWID.
OrthoDBEOG7Q8CN0.
PhylomeDBQ4AC99.
TreeFamTF354218.

Gene expression databases

BgeeQ4AC99.
GenevestigatorQ4AC99.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi390110.
NextBio103406.
PROQ4AC99.

Entry information

Entry name1A1L2_HUMAN
AccessionPrimary (citable) accession number: Q4AC99
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM