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Q4AC99

- 1A1L2_HUMAN

UniProt

Q4AC99 - 1A1L2_HUMAN

Protein

Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2

Gene

ACCSL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
    Short name:
    ACC synthase-like protein 2
    Gene namesi
    Name:ACCSL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:34391. ACCSL.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164714805.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2PRO_0000337057Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei395 – 3951N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PaxDbiQ4AC99.
    PRIDEiQ4AC99.

    PTM databases

    PhosphoSiteiQ4AC99.

    Expressioni

    Gene expression databases

    BgeeiQ4AC99.
    GenevestigatoriQ4AC99.

    Organism-specific databases

    HPAiHPA046163.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000368109.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4AC99.
    SMRiQ4AC99. Positions 150-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000033689.
    HOVERGENiHBG055243.
    InParanoidiQ4AC99.
    OMAiCTFEEEL.
    OrthoDBiEOG7Q8CN0.
    PhylomeDBiQ4AC99.
    TreeFamiTF354218.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4AC99-1 [UniParc]FASTAAdd to Basket

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    MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR    50
    QGLSLEERRH TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED 100
    SRGDVRYGQR AQLSGQPDPV PQLSDCEAAF VNRDLSIRGI DISVFYQSSF 150
    QDYNAYQKDK YHKDKNTLGF INLGTSENKL CMDLMTERLQ ESDMNCIEDT 200
    LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN GCCSVFCALA 250
    MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ 300
    LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR 350
    YNLHVIIDEI YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS 400
    GFRFGALYTH NKEVASAVSA FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL 450
    PTNCYRLREA HKYITAELKA LEIPFHNRSS GLYVWINLKK YLDPCTFEEE 500
    RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK LAMRRFCDVL 550
    QEQKEALIVK QLEDAMRE 568
    Length:568
    Mass (Da):65,249
    Last modified:May 18, 2010 - v3
    Checksum:i233FC638E76AC393
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921S → R in BAE17132. 1 PublicationCurated
    Sequence conflicti272 – 2721F → S in BAE17132. 1 PublicationCurated
    Sequence conflicti276 – 2761L → P in BAE17132. 1 PublicationCurated
    Sequence conflicti311 – 3111L → P in BAE17132. 1 PublicationCurated
    Sequence conflicti434 – 4341K → E in BAE17132. 1 PublicationCurated
    Sequence conflicti454 – 4541C → R in BAE17132. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti529 – 5291C → R.1 Publication
    Corresponds to variant rs2074051 [ dbSNP | Ensembl ].
    VAR_060626

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB231734 mRNA. Translation: BAE17132.1.
    AC134775 Genomic DNA. No translation available.
    CCDSiCCDS41636.1.
    RefSeqiNP_001027025.2. NM_001031854.2.
    UniGeneiHs.558851.

    Genome annotation databases

    EnsembliENST00000378832; ENSP00000368109; ENSG00000205126.
    GeneIDi390110.
    KEGGihsa:390110.
    UCSCiuc001mxw.1. human.

    Polymorphism databases

    DMDMi296439453.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB231734 mRNA. Translation: BAE17132.1 .
    AC134775 Genomic DNA. No translation available.
    CCDSi CCDS41636.1.
    RefSeqi NP_001027025.2. NM_001031854.2.
    UniGenei Hs.558851.

    3D structure databases

    ProteinModelPortali Q4AC99.
    SMRi Q4AC99. Positions 150-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000368109.

    PTM databases

    PhosphoSitei Q4AC99.

    Polymorphism databases

    DMDMi 296439453.

    Proteomic databases

    PaxDbi Q4AC99.
    PRIDEi Q4AC99.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378832 ; ENSP00000368109 ; ENSG00000205126 .
    GeneIDi 390110.
    KEGGi hsa:390110.
    UCSCi uc001mxw.1. human.

    Organism-specific databases

    CTDi 390110.
    GeneCardsi GC11P044027.
    HGNCi HGNC:34391. ACCSL.
    HPAi HPA046163.
    neXtProti NX_Q4AC99.
    PharmGKBi PA164714805.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000033689.
    HOVERGENi HBG055243.
    InParanoidi Q4AC99.
    OMAi CTFEEEL.
    OrthoDBi EOG7Q8CN0.
    PhylomeDBi Q4AC99.
    TreeFami TF354218.

    Miscellaneous databases

    GenomeRNAii 390110.
    NextBioi 103406.
    PROi Q4AC99.

    Gene expression databases

    Bgeei Q4AC99.
    Genevestigatori Q4AC99.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes predicted by combining multiple gene-finders."
      Totoki Y., Yada T., Sakaki Y., Takeda T.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-529.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry namei1A1L2_HUMAN
    AccessioniPrimary (citable) accession number: Q4AC99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 79 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number of residues which are necessary for activity thus suggesting that it lacks enzymatic activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3