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Protein

Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2

Gene

ACCSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Short name:
ACC synthase-like protein 2
Gene namesi
Name:ACCSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000205126.2.
HGNCiHGNC:34391. ACCSL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164714805.

Polymorphism and mutation databases

BioMutaiACCSL.
DMDMi296439453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370571 – 568Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei395N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ4AC99.
PeptideAtlasiQ4AC99.
PRIDEiQ4AC99.

PTM databases

iPTMnetiQ4AC99.
PhosphoSitePlusiQ4AC99.

Expressioni

Gene expression databases

BgeeiENSG00000205126.
ExpressionAtlasiQ4AC99. baseline and differential.

Organism-specific databases

HPAiHPA046163.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368109.

Structurei

3D structure databases

ProteinModelPortaliQ4AC99.
SMRiQ4AC99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0256. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00390000005703.
HOGENOMiHOG000033689.
HOVERGENiHBG055243.
InParanoidiQ4AC99.
OMAiQNTEWID.
OrthoDBiEOG091G04H3.
PhylomeDBiQ4AC99.
TreeFamiTF354218.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00155. Aminotran_1_2. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4AC99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR
60 70 80 90 100
QGLSLEERRH TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED
110 120 130 140 150
SRGDVRYGQR AQLSGQPDPV PQLSDCEAAF VNRDLSIRGI DISVFYQSSF
160 170 180 190 200
QDYNAYQKDK YHKDKNTLGF INLGTSENKL CMDLMTERLQ ESDMNCIEDT
210 220 230 240 250
LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN GCCSVFCALA
260 270 280 290 300
MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ
310 320 330 340 350
LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR
360 370 380 390 400
YNLHVIIDEI YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS
410 420 430 440 450
GFRFGALYTH NKEVASAVSA FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL
460 470 480 490 500
PTNCYRLREA HKYITAELKA LEIPFHNRSS GLYVWINLKK YLDPCTFEEE
510 520 530 540 550
RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK LAMRRFCDVL
560
QEQKEALIVK QLEDAMRE
Length:568
Mass (Da):65,249
Last modified:May 18, 2010 - v3
Checksum:i233FC638E76AC393
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192S → R in BAE17132 (Ref. 1) Curated1
Sequence conflicti272F → S in BAE17132 (Ref. 1) Curated1
Sequence conflicti276L → P in BAE17132 (Ref. 1) Curated1
Sequence conflicti311L → P in BAE17132 (Ref. 1) Curated1
Sequence conflicti434K → E in BAE17132 (Ref. 1) Curated1
Sequence conflicti454C → R in BAE17132 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060626529C → R1 PublicationCorresponds to variant dbSNP:rs2074051Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB231734 mRNA. Translation: BAE17132.1.
AC134775 Genomic DNA. No translation available.
CCDSiCCDS41636.1.
RefSeqiNP_001027025.2. NM_001031854.2.
UniGeneiHs.558851.

Genome annotation databases

EnsembliENST00000378832; ENSP00000368109; ENSG00000205126.
GeneIDi390110.
KEGGihsa:390110.
UCSCiuc001mxw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1A1L2_HUMAN
AccessioniPrimary (citable) accession number: Q4AC99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 98 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number of residues which are necessary for activity thus suggesting that it lacks enzymatic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families