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Protein

Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2

Gene

ACCSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Short name:
ACC synthase-like protein 2
Gene namesi
Name:ACCSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:34391. ACCSL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164714805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2PRO_0000337057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei395 – 3951N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ4AC99.
PRIDEiQ4AC99.

PTM databases

PhosphoSiteiQ4AC99.

Expressioni

Gene expression databases

BgeeiQ4AC99.
ExpressionAtlasiQ4AC99. baseline.
GenevestigatoriQ4AC99.

Organism-specific databases

HPAiHPA046163.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368109.

Structurei

3D structure databases

ProteinModelPortaliQ4AC99.
SMRiQ4AC99. Positions 150-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
GeneTreeiENSGT00390000005703.
HOGENOMiHOG000033689.
HOVERGENiHBG055243.
InParanoidiQ4AC99.
OMAiIVPVHCD.
OrthoDBiEOG7Q8CN0.
PhylomeDBiQ4AC99.
TreeFamiTF354218.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4AC99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR
60 70 80 90 100
QGLSLEERRH TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED
110 120 130 140 150
SRGDVRYGQR AQLSGQPDPV PQLSDCEAAF VNRDLSIRGI DISVFYQSSF
160 170 180 190 200
QDYNAYQKDK YHKDKNTLGF INLGTSENKL CMDLMTERLQ ESDMNCIEDT
210 220 230 240 250
LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN GCCSVFCALA
260 270 280 290 300
MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ
310 320 330 340 350
LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR
360 370 380 390 400
YNLHVIIDEI YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS
410 420 430 440 450
GFRFGALYTH NKEVASAVSA FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL
460 470 480 490 500
PTNCYRLREA HKYITAELKA LEIPFHNRSS GLYVWINLKK YLDPCTFEEE
510 520 530 540 550
RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK LAMRRFCDVL
560
QEQKEALIVK QLEDAMRE
Length:568
Mass (Da):65,249
Last modified:May 18, 2010 - v3
Checksum:i233FC638E76AC393
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921S → R in BAE17132 (Ref. 1) Curated
Sequence conflicti272 – 2721F → S in BAE17132 (Ref. 1) Curated
Sequence conflicti276 – 2761L → P in BAE17132 (Ref. 1) Curated
Sequence conflicti311 – 3111L → P in BAE17132 (Ref. 1) Curated
Sequence conflicti434 – 4341K → E in BAE17132 (Ref. 1) Curated
Sequence conflicti454 – 4541C → R in BAE17132 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti529 – 5291C → R.1 Publication
Corresponds to variant rs2074051 [ dbSNP | Ensembl ].
VAR_060626

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB231734 mRNA. Translation: BAE17132.1.
AC134775 Genomic DNA. No translation available.
CCDSiCCDS41636.1.
RefSeqiNP_001027025.2. NM_001031854.2.
UniGeneiHs.558851.

Genome annotation databases

EnsembliENST00000378832; ENSP00000368109; ENSG00000205126.
GeneIDi390110.
KEGGihsa:390110.
UCSCiuc001mxw.1. human.

Polymorphism databases

DMDMi296439453.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB231734 mRNA. Translation: BAE17132.1.
AC134775 Genomic DNA. No translation available.
CCDSiCCDS41636.1.
RefSeqiNP_001027025.2. NM_001031854.2.
UniGeneiHs.558851.

3D structure databases

ProteinModelPortaliQ4AC99.
SMRiQ4AC99. Positions 150-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368109.

PTM databases

PhosphoSiteiQ4AC99.

Polymorphism databases

DMDMi296439453.

Proteomic databases

PaxDbiQ4AC99.
PRIDEiQ4AC99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378832; ENSP00000368109; ENSG00000205126.
GeneIDi390110.
KEGGihsa:390110.
UCSCiuc001mxw.1. human.

Organism-specific databases

CTDi390110.
GeneCardsiGC11P044027.
HGNCiHGNC:34391. ACCSL.
HPAiHPA046163.
neXtProtiNX_Q4AC99.
PharmGKBiPA164714805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0436.
GeneTreeiENSGT00390000005703.
HOGENOMiHOG000033689.
HOVERGENiHBG055243.
InParanoidiQ4AC99.
OMAiIVPVHCD.
OrthoDBiEOG7Q8CN0.
PhylomeDBiQ4AC99.
TreeFamiTF354218.

Miscellaneous databases

GenomeRNAii390110.
NextBioi103406.
PROiQ4AC99.

Gene expression databases

BgeeiQ4AC99.
ExpressionAtlasiQ4AC99. baseline.
GenevestigatoriQ4AC99.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel human genes predicted by combining multiple gene-finders."
    Totoki Y., Yada T., Sakaki Y., Takeda T.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-529.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry namei1A1L2_HUMAN
AccessioniPrimary (citable) accession number: Q4AC99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: March 4, 2015
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number of residues which are necessary for activity thus suggesting that it lacks enzymatic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.