SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4AC99

- 1A1L2_HUMAN

UniProt

Q4AC99 - 1A1L2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2

Gene
ACCSL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Short name:
ACC synthase-like protein 2
Gene namesi
Name:ACCSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:34391. ACCSL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164714805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2PRO_0000337057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei395 – 3951N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiQ4AC99.
PRIDEiQ4AC99.

PTM databases

PhosphoSiteiQ4AC99.

Expressioni

Gene expression databases

BgeeiQ4AC99.
GenevestigatoriQ4AC99.

Organism-specific databases

HPAiHPA046163.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368109.

Structurei

3D structure databases

ProteinModelPortaliQ4AC99.
SMRiQ4AC99. Positions 150-549.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000033689.
HOVERGENiHBG055243.
InParanoidiQ4AC99.
OMAiCTFEEEL.
OrthoDBiEOG7Q8CN0.
PhylomeDBiQ4AC99.
TreeFamiTF354218.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4AC99-1 [UniParc]FASTAAdd to Basket

« Hide

MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR    50
QGLSLEERRH TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED 100
SRGDVRYGQR AQLSGQPDPV PQLSDCEAAF VNRDLSIRGI DISVFYQSSF 150
QDYNAYQKDK YHKDKNTLGF INLGTSENKL CMDLMTERLQ ESDMNCIEDT 200
LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN GCCSVFCALA 250
MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ 300
LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR 350
YNLHVIIDEI YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS 400
GFRFGALYTH NKEVASAVSA FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL 450
PTNCYRLREA HKYITAELKA LEIPFHNRSS GLYVWINLKK YLDPCTFEEE 500
RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK LAMRRFCDVL 550
QEQKEALIVK QLEDAMRE 568
Length:568
Mass (Da):65,249
Last modified:May 18, 2010 - v3
Checksum:i233FC638E76AC393
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti529 – 5291C → R.1 Publication
Corresponds to variant rs2074051 [ dbSNP | Ensembl ].
VAR_060626

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921S → R in BAE17132. 1 Publication
Sequence conflicti272 – 2721F → S in BAE17132. 1 Publication
Sequence conflicti276 – 2761L → P in BAE17132. 1 Publication
Sequence conflicti311 – 3111L → P in BAE17132. 1 Publication
Sequence conflicti434 – 4341K → E in BAE17132. 1 Publication
Sequence conflicti454 – 4541C → R in BAE17132. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB231734 mRNA. Translation: BAE17132.1.
AC134775 Genomic DNA. No translation available.
CCDSiCCDS41636.1.
RefSeqiNP_001027025.2. NM_001031854.2.
UniGeneiHs.558851.

Genome annotation databases

EnsembliENST00000378832; ENSP00000368109; ENSG00000205126.
GeneIDi390110.
KEGGihsa:390110.
UCSCiuc001mxw.1. human.

Polymorphism databases

DMDMi296439453.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB231734 mRNA. Translation: BAE17132.1 .
AC134775 Genomic DNA. No translation available.
CCDSi CCDS41636.1.
RefSeqi NP_001027025.2. NM_001031854.2.
UniGenei Hs.558851.

3D structure databases

ProteinModelPortali Q4AC99.
SMRi Q4AC99. Positions 150-549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000368109.

PTM databases

PhosphoSitei Q4AC99.

Polymorphism databases

DMDMi 296439453.

Proteomic databases

PaxDbi Q4AC99.
PRIDEi Q4AC99.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378832 ; ENSP00000368109 ; ENSG00000205126 .
GeneIDi 390110.
KEGGi hsa:390110.
UCSCi uc001mxw.1. human.

Organism-specific databases

CTDi 390110.
GeneCardsi GC11P044027.
HGNCi HGNC:34391. ACCSL.
HPAi HPA046163.
neXtProti NX_Q4AC99.
PharmGKBi PA164714805.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000033689.
HOVERGENi HBG055243.
InParanoidi Q4AC99.
OMAi CTFEEEL.
OrthoDBi EOG7Q8CN0.
PhylomeDBi Q4AC99.
TreeFami TF354218.

Miscellaneous databases

GenomeRNAii 390110.
NextBioi 103406.
PROi Q4AC99.

Gene expression databases

Bgeei Q4AC99.
Genevestigatori Q4AC99.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of novel human genes predicted by combining multiple gene-finders."
    Totoki Y., Yada T., Sakaki Y., Takeda T.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-529.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry namei1A1L2_HUMAN
AccessioniPrimary (citable) accession number: Q4AC99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number of residues which are necessary for activity thus suggesting that it lacks enzymatic activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi