Q4AC99 (1A1L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-aminocyclopropane-1-carboxylate synthase-like protein 2
Short name=ACC synthase-like protein 2

Gene names

Name:

ACCSL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Caution	Similar to plant 1-aminocyclopropane-1-carboxylate synthases but lacks a number of residues which are necessary for activity.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Pyridoxal phosphate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring nitrogenous groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	1-aminocyclopropane-1-carboxylate synthase-like protein 2		PRO_0000337057
Amino acid modifications
	Modified residue	395	1	N6-(pyridoxal phosphate)lysine By similarity
Natural variations
	Natural variant	529	1	C → R. Ref.1 Corresponds to variant rs2074051 [ dbSNP | Ensembl ].		VAR_060626
Experimental info
	Sequence conflict	192	1	S → R in BAE17132. Ref.1
	Sequence conflict	272	1	F → S in BAE17132. Ref.1
	Sequence conflict	276	1	L → P in BAE17132. Ref.1
	Sequence conflict	311	1	L → P in BAE17132. Ref.1
	Sequence conflict	434	1	K → E in BAE17132. Ref.1
	Sequence conflict	454	1	C → R in BAE17132. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q4AC99 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 233FC638E76AC393	FASTA	568	65,249
	10 20 30 40 50 60 MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR QGLSLEERRH 70 80 90 100 110 120 TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED SRGDVRYGQR AQLSGQPDPV 130 140 150 160 170 180 PQLSDCEAAF VNRDLSIRGI DISVFYQSSF QDYNAYQKDK YHKDKNTLGF INLGTSENKL 190 200 210 220 230 240 CMDLMTERLQ ESDMNCIEDT LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN 250 260 270 280 290 300 GCCSVFCALA MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ 310 320 330 340 350 360 LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR YNLHVIIDEI 370 380 390 400 410 420 YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS GFRFGALYTH NKEVASAVSA 430 440 450 460 470 480 FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL PTNCYRLREA HKYITAELKA LEIPFHNRSS 490 500 510 520 530 540 GLYVWINLKK YLDPCTFEEE RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK 550 560 LAMRRFCDVL QEQKEALIVK QLEDAMRE

References

[1]

"Identification of novel human genes predicted by combining multiple gene-finders." Totoki Y., Yada T., Sakaki Y., Takeda T. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-529.

[2]

"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB231734 mRNA. Translation: BAE17132.1. AC134775 Genomic DNA. No translation available.
IPI	IPI00399296.
RefSeq	NP_001027025.2. NM_001031854.2.
UniGene	Hs.558851.
3D structure databases
ProteinModelPortal	Q4AC99.
SMR	Q4AC99. Positions 135-554.
ModBase	Search...
Polymorphism databases
DMDM	296439453.
Proteomic databases
PRIDE	Q4AC99.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378832; ENSP00000368109; ENSG00000205126.
GeneID	390110.
KEGG	hsa:390110.
UCSC	uc001mxw.1. human.
Organism-specific databases
CTD	390110.
GeneCards	GC11P044027.
HGNC	HGNC:34391. ACCSL.
neXtProt	NX_Q4AC99.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000005703.
HOGENOM	HBG713659.
HOVERGEN	HBG055243.
InParanoid	Q4AC99.
OMA	IIDEIYM.
OrthoDB	EOG4P8FJ0.
PhylomeDB	Q4AC99.
Gene expression databases
Genevestigator	Q4AC99.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	103406.

Entry information

Entry name

1A1L2_HUMAN

Accession

Primary (citable) accession number: Q4AC99

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 55 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.