Q4AC99 (1A1L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Short name=ACC synthase-like protein 2

Gene names

Name:

ACCSL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Caution	While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number of residues which are necessary for activity thus suggesting that it lacks enzymatic activity.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Pyridoxal phosphate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2		PRO_0000337057
Amino acid modifications
	Modified residue	395	1	N6-(pyridoxal phosphate)lysine By similarity
Natural variations
	Natural variant	529	1	C → R. Ref.1 Corresponds to variant rs2074051 [ dbSNP | Ensembl ].		VAR_060626
Experimental info
	Sequence conflict	192	1	S → R in BAE17132. Ref.1
	Sequence conflict	272	1	F → S in BAE17132. Ref.1
	Sequence conflict	276	1	L → P in BAE17132. Ref.1
	Sequence conflict	311	1	L → P in BAE17132. Ref.1
	Sequence conflict	434	1	K → E in BAE17132. Ref.1
	Sequence conflict	454	1	C → R in BAE17132. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q4AC99 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 233FC638E76AC393	FASTA	568	65,249
	10 20 30 40 50 60 MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR QGLSLEERRH 70 80 90 100 110 120 TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED SRGDVRYGQR AQLSGQPDPV 130 140 150 160 170 180 PQLSDCEAAF VNRDLSIRGI DISVFYQSSF QDYNAYQKDK YHKDKNTLGF INLGTSENKL 190 200 210 220 230 240 CMDLMTERLQ ESDMNCIEDT LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN 250 260 270 280 290 300 GCCSVFCALA MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ 310 320 330 340 350 360 LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR YNLHVIIDEI 370 380 390 400 410 420 YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS GFRFGALYTH NKEVASAVSA 430 440 450 460 470 480 FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL PTNCYRLREA HKYITAELKA LEIPFHNRSS 490 500 510 520 530 540 GLYVWINLKK YLDPCTFEEE RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK 550 560 LAMRRFCDVL QEQKEALIVK QLEDAMRE

References

[1]

"Identification of novel human genes predicted by combining multiple gene-finders." Totoki Y., Yada T., Sakaki Y., Takeda T. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-529.

[2]

"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB231734 mRNA. Translation: BAE17132.1. AC134775 Genomic DNA. No translation available.
IPI	IPI00399296.
RefSeq	NP_001027025.2. NM_001031854.2.
UniGene	Hs.558851.
3D structure databases
ProteinModelPortal	Q4AC99.
SMR	Q4AC99. Positions 150-549.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000368109.
PTM databases
PhosphoSite	Q4AC99.
Polymorphism databases
DMDM	296439453.
Proteomic databases
PaxDb	Q4AC99.
PRIDE	Q4AC99.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378832; ENSP00000368109; ENSG00000205126.
GeneID	390110.
KEGG	hsa:390110.
UCSC	uc001mxw.1. human.
Organism-specific databases
CTD	390110.
GeneCards	GC11P044027.
HGNC	HGNC:34391. ACCSL.
HPA	HPA046163.
neXtProt	NX_Q4AC99.
PharmGKB	PA164714805.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0436.
HOGENOM	HOG000033689.
HOVERGEN	HBG055243.
InParanoid	Q4AC99.
OMA	IIDEIYM.
OrthoDB	EOG4P8FJ0.
Gene expression databases
ArrayExpress	Q4AC99.
Bgee	Q4AC99.
Genevestigator	Q4AC99.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390110.
NextBio	103406.

Entry information

Entry name

1A1L2_HUMAN

Accession

Primary (citable) accession number: Q4AC99

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 67 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.