Q4A9F3 (G6PI_MYCHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	MHJ_0532

Organism

Mycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) [Complete proteome] [HAMAP]

Taxonomic identifier

262719 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180682
Sites
	Active site	282	1	Proton donor By similarity
	Active site	303	1	By similarity
	Active site	418	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4A9F3 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: FA09104D0C6AC779	FASTA	429	48,556
	10 20 30 40 50 60 MSLKLEVKTE IKLDYQGFQN QINEFHNRIN DKNSPDINFL GWNNFPEVAI NPQEIARMRK 70 80 90 100 110 120 IVENLHQNSI NVLVVIGIGG SYLGAKAALD FILGLGPFEN KPEVIFLGNS LSSTDLYQKI 130 140 150 160 170 180 EYLKTKNFAI NVISKSGSTI EPAITFQILY QFLIDQIGEK LAKTRTFVTT SIKSGELLEI 190 200 210 220 230 240 AKSNELEIFE VIESIGGRFS VLSSVGFFPL LFAKINVDEI IQGAIEAHKR YSTSSISQNL 250 260 270 280 290 300 AYKYALFRFL MYKNFNYKTE ILISYEPFLI YFNEWWKQLF GESEGKNLKG LFPASAIFTT 310 320 330 340 350 360 DLHSLGQFIQ DGSKNFFQTI IYIKKPKFDL GIKKIVQFNT KINKLSGKTV SEINFQAFLA 370 380 390 400 410 420 TTLAHSSYGN NPNLVLEIAD SSPKTFGHLV MFFEKACAMS AYLLGVNPFD QPGVESYKNE LAKNLGWDR

References

[1]

"Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae." Vasconcelos A.T.R., Ferreira H.B., Bizarro C.V., Bonatto S.L., Carvalho M.O., Pinto P.M., Almeida D.F., Almeida L.G.P., Almeida R., Alves-Junior L., Assuncao E.N., Azevedo V.A.C., Bogo M.R., Brigido M.M., Brocchi M., Burity H.A., Camargo A.A., Camargo S.S. , Carepo M.S., Carraro D.M., de Mattos Cascardo J.C., Castro L.A., Cavalcanti G., Chemale G., Collevatti R.G., Cunha C.W., Dallagiovanna B., Dambros B.P., Dellagostin O.A., Falcao C., Fantinatti-Garboggini F., Felipe M.S.S., Fiorentin L., Franco G.R., Freitas N.S.A., Frias D., Grangeiro T.B., Grisard E.C., Guimaraes C.T., Hungria M., Jardim S.N., Krieger M.A., Laurino J.P., Lima L.F.A., Lopes M.I., Loreto E.L.S., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martinkovics C.T., Medeiros S.R.B., Moreira M.A.M., Neiva M., Ramalho-Neto C.E., Nicolas M.F., Oliveira S.C., Paixao R.F.C., Pedrosa F.O., Pena S.D.J., Pereira M., Pereira-Ferrari L., Piffer I., Pinto L.S., Potrich D.P., Salim A.C.M., Santos F.R., Schmitt R., Schneider M.P.C., Schrank A., Schrank I.S., Schuck A.F., Seuanez H.N., Silva D.W., Silva R., Silva S.C., Soares C.M.A., Souza K.R.L., Souza R.C., Staats C.C., Steffens M.B.R., Teixeira S.M.R., Urmenyi T.P., Vainstein M.H., Zuccherato L.W., Simpson A.J.G., Zaha A. J. Bacteriol. 187:5568-5577(2005) [PubMed: 16077101] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J / ATCC 25934 / NCTC 10110.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017243 Genomic DNA. Translation: AAZ44618.1.
RefSeq	YP_279329.1. NC_007295.1.
3D structure databases
ProteinModelPortal	Q4A9F3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4A9F3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3563889.
GenomeReviews	Gene locus MHJ_0532 in contig AE017243_GR.
KEGG	mhj:MHJ_0532.
PATRIC	20014942. VBIMycHyo90918_0594.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG615843.
OMA	RINDKNS.
PhylomeDB	Q4A9F3.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	MHYO262719:MHJ_0532-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_MYCHJ

Accession

Primary (citable) accession number: Q4A9F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program