ID TRMB_MESH7 Reviewed; 201 AA. AC Q4A7Q7; DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot. DT 13-SEP-2005, sequence version 1. DT 27-MAR-2024, entry version 106. DE RecName: Full=tRNA (guanine-N(7)-)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_01057}; DE EC=2.1.1.33 {ECO:0000255|HAMAP-Rule:MF_01057}; DE AltName: Full=tRNA (guanine(46)-N(7))-methyltransferase {ECO:0000255|HAMAP-Rule:MF_01057}; DE AltName: Full=tRNA(m7G46)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_01057}; GN Name=trmB {ECO:0000255|HAMAP-Rule:MF_01057}; GN OrderedLocusNames=MHP7448_0465; OS Mesomycoplasma hyopneumoniae (strain 7448) (Mycoplasma hyopneumoniae). OC Bacteria; Mycoplasmatota; Mycoplasmoidales; Metamycoplasmataceae; OC Mesomycoplasma. OX NCBI_TaxID=262722; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=7448; RX PubMed=16077101; DOI=10.1128/jb.187.16.5568-5577.2005; RA Vasconcelos A.T.R., Ferreira H.B., Bizarro C.V., Bonatto S.L., RA Carvalho M.O., Pinto P.M., Almeida D.F., Almeida L.G.P., Almeida R., RA Alves-Junior L., Assuncao E.N., Azevedo V.A.C., Bogo M.R., Brigido M.M., RA Brocchi M., Burity H.A., Camargo A.A., Camargo S.S., Carepo M.S., RA Carraro D.M., de Mattos Cascardo J.C., Castro L.A., Cavalcanti G., RA Chemale G., Collevatti R.G., Cunha C.W., Dallagiovanna B., Dambros B.P., RA Dellagostin O.A., Falcao C., Fantinatti-Garboggini F., Felipe M.S.S., RA Fiorentin L., Franco G.R., Freitas N.S.A., Frias D., Grangeiro T.B., RA Grisard E.C., Guimaraes C.T., Hungria M., Jardim S.N., Krieger M.A., RA Laurino J.P., Lima L.F.A., Lopes M.I., Loreto E.L.S., Madeira H.M.F., RA Manfio G.P., Maranhao A.Q., Martinkovics C.T., Medeiros S.R.B., RA Moreira M.A.M., Neiva M., Ramalho-Neto C.E., Nicolas M.F., Oliveira S.C., RA Paixao R.F.C., Pedrosa F.O., Pena S.D.J., Pereira M., Pereira-Ferrari L., RA Piffer I., Pinto L.S., Potrich D.P., Salim A.C.M., Santos F.R., Schmitt R., RA Schneider M.P.C., Schrank A., Schrank I.S., Schuck A.F., Seuanez H.N., RA Silva D.W., Silva R., Silva S.C., Soares C.M.A., Souza K.R.L., Souza R.C., RA Staats C.C., Steffens M.B.R., Teixeira S.M.R., Urmenyi T.P., RA Vainstein M.H., Zuccherato L.W., Simpson A.J.G., Zaha A.; RT "Swine and poultry pathogens: the complete genome sequences of two strains RT of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae."; RL J. Bacteriol. 187:5568-5577(2005). CC -!- FUNCTION: Catalyzes the formation of N(7)-methylguanine at position 46 CC (m7G46) in tRNA. {ECO:0000255|HAMAP-Rule:MF_01057}. CC -!- CATALYTIC ACTIVITY: CC Reaction=guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)- CC methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine; CC Xref=Rhea:RHEA:42708, Rhea:RHEA-COMP:10188, Rhea:RHEA-COMP:10189, CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, CC ChEBI:CHEBI:74480; EC=2.1.1.33; Evidence={ECO:0000255|HAMAP- CC Rule:MF_01057}; CC -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis. CC {ECO:0000255|HAMAP-Rule:MF_01057}. CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase CC superfamily. TrmB family. {ECO:0000255|HAMAP-Rule:MF_01057}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017244; AAZ53832.1; -; Genomic_DNA. DR RefSeq; WP_011290278.1; NC_007332.1. DR AlphaFoldDB; Q4A7Q7; -. DR SMR; Q4A7Q7; -. DR KEGG; mhp:MHP7448_0465; -. DR HOGENOM; CLU_050910_2_1_14; -. DR UniPathway; UPA00989; -. DR Proteomes; UP000000553; Chromosome. DR GO; GO:0008176; F:tRNA (guanine(46)-N7)-methyltransferase activity; IEA:UniProtKB-UniRule. DR CDD; cd02440; AdoMet_MTases; 1. DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1. DR HAMAP; MF_01057; tRNA_methyltr_TrmB; 1. DR InterPro; IPR029063; SAM-dependent_MTases_sf. DR InterPro; IPR003358; tRNA_(Gua-N-7)_MeTrfase_Trmb. DR NCBIfam; TIGR00091; tRNA (guanosine(46)-N7)-methyltransferase TrmB; 1. DR PANTHER; PTHR23417; 3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE; 1. DR PANTHER; PTHR23417:SF14; PPR_LONG DOMAIN-CONTAINING PROTEIN; 1. DR Pfam; PF02390; Methyltransf_4; 1. DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1. DR PROSITE; PS51625; SAM_MT_TRMB; 1. PE 3: Inferred from homology; KW Methyltransferase; S-adenosyl-L-methionine; Transferase; tRNA processing. FT CHAIN 1..201 FT /note="tRNA (guanine-N(7)-)-methyltransferase" FT /id="PRO_0000229174" FT ACT_SITE 106 FT /evidence="ECO:0000250" FT BINDING 33 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01057" FT BINDING 58 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01057" FT BINDING 85 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01057" FT BINDING 106 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01057" FT BINDING 110 FT /ligand="substrate" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01057" FT BINDING 142 FT /ligand="substrate" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01057" FT BINDING 180..183 FT /ligand="substrate" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01057" SQ SEQUENCE 201 AA; 23727 MW; C59D5614A4262460 CRC64; MRLRNIPDAL ERIQNQNLLV KTPWNIDDSW IIEIGMGKGK MISQLAFDNP NKNFLGVEKY PSAAVKSIKY VKKYNLSNFF ILISDAKDLL DQIKGKANTI WLTFPDPWPK NRHYKRRLTY KDFLKIYANL LVKDGILKLK TDNLKFFEFS IESLKENGWK ITYQTNDLHN SLVNSSNIKT TYEEKWVNLN YKIHYLEAIF I //