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Q4A691 (Q4A691_MYCS5) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897

EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897 EMBL AAZ43730.1
Ordered Locus Names:MS53_0317 EMBL AAZ43730.1
OrganismMycoplasma synoviae (strain 53) [Complete proteome] [HAMAP] EMBL AAZ43730.1
Taxonomic identifier262723 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length865 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS006691

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1781O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q4A691 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 7B245F932B48ABEC

FASTA86596,835
        10         20         30         40         50         60 
MIDNNKENSE YILDEDEFEE DQPELVFKQE IKKDEEEDDT EIPPQEEESY RAQSKLIDEP 

        70         80         90        100        110        120 
TEGLTPVAIH DEVETSFLDY AMSVLVSRAI PDARDGLKPV HRRILYDMSE LGMTPGTQYK 

       130        140        150        160        170        180 
KSARIVGDVL GKYHPHGDSS VYNAMVRLAQ DFSMRYPLVD GHGNFGSIDG DEPASMRYTE 

       190        200        210        220        230        240 
ARMAKISTEL LEGIKKNTVD FVDNYDSTEK EPAVLPSRFP NLLVSGSIGI AVGMATSIPP 

       250        260        270        280        290        300 
HNLKETIDAV IAYARNKDIT VEELLQYIKG PDFPTGGVIL GTKGILEAYK TGRGQIPLRS 

       310        320        330        340        350        360 
EYEIVQLKNE KFRIIITKIP YNIRKSAIVE SISKLDKENA VEGISDLRDE SNRDGIRIVI 

       370        380        390        400        410        420 
DIKKGFNPEV VLNKLFKKSS LLTKFSVNMV ALVNTQPKLL TLKDVLDVYL EHQKEVLTRE 

       430        440        450        460        470        480 
LNFDLKKAQD SIHILEGLLV ATNNIDDVVA LIKSSSSDEV ASKKLIEKYS LSEEQAKAIL 

       490        500        510        520        530        540 
NMRLGRLTGL SYSKMTNEIE ELRKEIQRIT SILDSEQELV NNVIADLEKI KEKYGDSRKT 

       550        560        570        580        590        600 
SIDASASSSI NEEQLIPRKD IVITATVDGF VKRVNLEEYN LQNRGGMGST GMKTWSGDAI 

       610        620        630        640        650        660 
LSIIQTNTHV DLFLFSNLGK VYKLRAYKIQ EADKKSKGNS FANLVELNKE LNEKIIRILP 

       670        680        690        700        710        720 
VDSYESNLHL LTVTKKGIVK KTALDNFKKV RSNGIKAFKL KDEEDELKDV ILVTNSDLVL 

       730        740        750        760        770        780 
VANNHKNVVK FEASKIRSQA RNSIGVQGMK LDGKYEVQSI SSSKEGEFVL TIGEFGFGKL 

       790        800        810        820        830        840 
TDHKEYSLTN RNAKGKTSIN PAKAGNLVFA KFVNPTDELL IITAQGNTIR TQLDQVSVFS 

       850        860 
RNSKGVRIIK LNEGDKIISV EVIKN 

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References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017245 Genomic DNA. Translation: AAZ43730.1.
RefSeqYP_278441.1. NC_007294.1.

3D structure databases

ProteinModelPortalQ4A691.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262723.MS53_0317.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ43730; AAZ43730; MS53_0317.
GeneID3564581.
KEGGmsy:MS53_0317.
PATRIC20025232. VBIMycSyn118523_0343.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAETVDWVP.
OrthoDBEOG661H5V.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycMSYN262723:GH37-319-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ4A691_MYCS5
AccessionPrimary (citable) accession number: Q4A691
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)