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Q4A5P2

- Q4A5P2_MYCS5

UniProt

Q4A5P2 - Q4A5P2_MYCS5

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Protein

Thymidine kinase

Gene
tdk, MS53_0521
Organism
Mycoplasma synoviae (strain 53)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi148 – 1481Zinc By similarityUniRule annotation
Metal bindingi176 – 1761Zinc By similarityUniRule annotation
Metal bindingi179 – 1791Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarityUniRule annotation
Nucleotide bindingi88 – 914ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMSYN262723:GH37-533-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:MS53_0521Imported
OrganismiMycoplasma synoviae (strain 53)Imported
Taxonomic identifieri262723 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000549: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi262723.MS53_0521.

Structurei

3D structure databases

ProteinModelPortaliQ4A5P2.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiDHISEST.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4A5P2-1 [UniParc]FASTAAdd to Basket

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MRWKYDIGSL EVITGPMFAG KSNEIIRILN VNQIAGFKPL SFKPDFDTRW    50
SVNHIVSRTG SKMETINLKD PKDIWNHIKK DTQVIAFDEV HFFDMSIVAE 100
IQKLIEKKYK VIVSGLDMDY LGKPFEVVSQ LCCLADKIKK LKAVCMNCHG 150
VANMTYRKVD NNERNLLGDS EYEARCRNCH KLR 183
Length:183
Mass (Da):21,146
Last modified:September 13, 2005 - v1
Checksum:iCA97CF80A439C64E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017245 Genomic DNA. Translation: AAZ43929.1.
RefSeqiWP_011283658.1. NC_007294.1.
YP_278640.1. NC_007294.1.

Genome annotation databases

EnsemblBacteriaiAAZ43929; AAZ43929; MS53_0521.
GeneIDi3564556.
KEGGimsy:MS53_0521.
PATRICi20025684. VBIMycSyn118523_0557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017245 Genomic DNA. Translation: AAZ43929.1 .
RefSeqi WP_011283658.1. NC_007294.1.
YP_278640.1. NC_007294.1.

3D structure databases

ProteinModelPortali Q4A5P2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262723.MS53_0521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ43929 ; AAZ43929 ; MS53_0521 .
GeneIDi 3564556.
KEGGi msy:MS53_0521.
PATRICi 20025684. VBIMycSyn118523_0557.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi DHISEST.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci MSYN262723:GH37-533-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae."
    Vasconcelos A.T., Ferreira H.B., Bizarro C.V., Bonatto S.L., Carvalho M.O., Pinto P.M., Almeida D.F., Almeida L.G., Almeida R., Alves-Filho L., Assuncao E.N., Azevedo V.A., Bogo M.R., Brigido M.M., Brocchi M., Burity H.A., Camargo A.A., Camargo S.S.
    , Carepo M.S., Carraro D.M., de Mattos Cascardo J.C., Castro L.A., Cavalcanti G., Chemale G., Collevatti R.G., Cunha C.W., Dallagiovanna B., Dambros B.P., Dellagostin O.A., Falcao C., Fantinatti-Garboggini F., Felipe M.S., Fiorentin L., Franco G.R., Freitas N.S., Frias D., Grangeiro T.B., Grisard E.C., Guimaraes C.T., Hungria M., Jardim S.N., Krieger M.A., Laurino J.P., Lima L.F., Lopes M.I., Loreto E.L., Madeira H.M., Manfio G.P., Maranhao A.Q., Martinkovics C.T., Medeiros S.R., Moreira M.A., Neiva M., Ramalho-Neto C.E., Nicolas M.F., Oliveira S.C., Paixao R.F., Pedrosa F.O., Pena S.D., Pereira M., Pereira-Ferrari L., Piffer I., Pinto L.S., Potrich D.P., Salim A.C., Santos F.R., Schmitt R., Schneider M.P., Schrank A., Schrank I.S., Schuck A.F., Seuanez H.N., Silva D.W., Silva R., Silva S.C., Soares C.M., Souza K.R., Souza R.C., Staats C.C., Steffens M.B., Teixeira S.M., Urmenyi T.P., Vainstein M.H., Zuccherato L.W., Simpson A.J., Zaha A.
    J. Bacteriol. 187:5568-5577(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 53Imported.

Entry informationi

Entry nameiQ4A5P2_MYCS5
AccessioniPrimary (citable) accession number: Q4A5P2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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