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Protein

Ribonuclease 3

Gene

rnc

Organism
Mycoplasma synoviae (strain 53)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52MagnesiumUniRule annotation1
Active sitei56UniRule annotation1
Metal bindingi125MagnesiumUniRule annotation1
Active sitei128UniRule annotation1
Metal bindingi128MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMSYN262723:G1G0T-713-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:MS53_0675
OrganismiMycoplasma synoviae (strain 53)
Taxonomic identifieri262723 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000549 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002285521 – 231Ribonuclease 3Add BLAST231

Proteomic databases

PRIDEiQ4A589

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi262723.MS53_0675

Structurei

3D structure databases

ProteinModelPortaliQ4A589
SMRiQ4A589
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 139RNase IIIUniRule annotationAdd BLAST128
Domaini165 – 231DRBMUniRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SU0 Bacteria
COG0571 LUCA
HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4A589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKDNQPSIE ELKAFLQKNN IEYKNIDLFI EATTHKTYSK VNKNSKDYER
60 70 80 90 100
LEFLGDSLVG FLISDYCVRE FSSLEPGELS RLRSKLVDKL ALFKIAQKLK
110 120 130 140 150
VEQIIKTGPK KARNEVLSSS NVLSDVVEAL IAAIYLDQGM QSAKDFIKSH
160 170 180 190 200
FYEIANKAQN KPNKDPKSEL QEYFQTISAE TVKYETIEIP NKRSFESKAW
210 220 230
HLNKIYGTGV GLSKKDAEKN AAANALSKLK T
Length:231
Mass (Da):26,235
Last modified:September 13, 2005 - v1
Checksum:iBF47EE3F88964D7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017245 Genomic DNA Translation: AAZ44082.1
RefSeqiWP_011283811.1, NC_007294.1

Genome annotation databases

EnsemblBacteriaiAAZ44082; AAZ44082; MS53_0675
KEGGimsy:MS53_0675

Similar proteinsi

Entry informationi

Entry nameiRNC_MYCS5
AccessioniPrimary (citable) accession number: Q4A589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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