Q4A1L4 (BECN1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beclin-1

Gene names

Name:

BECN1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense By similarity.
Subunit structure	Interacts with BCL2 and BCL2L1 By similarity. Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 upregulates autophagy, while the one containing Rubicon downregulates autophagy By similarity. Interacts with VMP1 By similarity. Interacts with PIK3CB By similarity. Interacts with DAPK1 By similarity.
Subcellular location	Cytoplasm. Golgi apparatus › trans-Golgi network membrane; Peripheral membrane protein By similarity. Note: Interaction with KIAA0831/Barkor promotes translocation to autophagosomes By similarity.
Post-translational modification	Phosphorylation at Thr-117 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy By similarity.
Sequence similarities	Belongs to the beclin family.

Ontologies

Keywords
Biological process	Antiviral defense Autophagy Cell cycle Cell division
Cellular component	Cytoplasm Golgi apparatus Membrane
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Inferred from sequence or structural similarity. Source: UniProtKB response to virus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Beclin-1		PRO_0000244423
Regions
	Coiled coil	140 – 267	128	Potential
Amino acid modifications
	Modified residue	28	1	Phosphothreonine By similarity
	Modified residue	29	1	Phosphoserine By similarity
	Modified residue	56	1	Phosphothreonine By similarity
	Modified residue	63	1	Phosphoserine By similarity
	Modified residue	88	1	Phosphoserine By similarity
	Modified residue	91	1	Phosphoserine By similarity
	Modified residue	94	1	Phosphoserine By similarity
	Modified residue	117	1	Phosphothreonine; by DAPK1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4A1L4 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: F2B86F42D8510855	FASTA	448	51,581
	10 20 30 40 50 60 MEGSKTSSST MQVSFVCQRC SQPLKLDTSF KILDRVTIQE LTAPLLATAQ LKPGETQEEE 70 80 90 100 110 120 ANSGEEPFIE TRQDGVSRRF IPPARMMSTE SANSFTLIGE ASDGGTMENL SRRLKVTGDL 130 140 150 160 170 180 FDIMSGQTDV DHPLCEECTD TLLDQLDTQL NVTENECQNY KRCLEILEQM NEDDSEQLGL 190 200 210 220 230 240 ELKELALEEE RLIQELEDVE KNRKIVAENL EKVQAEAERL DQEEAQYQRE YSEFKRQQLE 250 260 270 280 290 300 LDDELKSVEN QMRYAQMQLD KLKKTNVFNA TFHIWHSGQF GTINNFRLGR LPSVPVEWNE 310 320 330 340 350 360 INAAWGQTVL LLHALANKMG LKFQRYRLVP YGNHSYLESL TDKSKELPLY CSGGLRFFWD 370 380 390 400 410 420 NKFDHAMVAF LDCVQQFKEE VEKGETRFCL PYRMDVEKGK IEDTGGSGGS YSIKTQFNSE 430 440 EQWTKALKFM LTNLKWGLAW VSSQFYNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Phylogeny and biochemistry of the autophagy protein beclin 1." Botti J., Djavaheri-Mergny M., Codogno P., Oriol R. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM051355 mRNA. Translation: CAJ19744.1. BC102177 mRNA. Translation: AAI02178.1.
IPI	IPI00698174.
RefSeq	NP_001028799.1. NM_001033627.1.
UniGene	Bt.24256.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4A1L4.
Proteomic databases
PRIDE	Q4A1L4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000026531; ENSBTAP00000026531; ENSBTAG00000019914.
GeneID	527278.
KEGG	bta:527278.
Organism-specific databases
CTD	8678.
Phylogenomic databases
eggNOG	maNOG10468.
GeneTree	ENSGT00390000008164.
HOVERGEN	HBG003181.
InParanoid	Q4A1L4.
OMA	LDTQLNI.
OrthoDB	EOG4320Z3.
PhylomeDB	Q4A1L4.
Family and domain databases
InterPro	IPR007243. Autophagy-rel_prot_6. [Graphical view]
KO	K08334.
PANTHER	PTHR12768. APG6. 1 hit.
Pfam	PF04111. APG6. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BECN1_BOVIN

Accession

Primary (citable) accession number: Q4A1L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	September 13, 2005
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program