ID   GTAB1_STAS1             Reviewed;         287 AA.
AC   Q4A122;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase 1;
DE            EC=2.7.7.9;
DE   AltName: Full=UDP-glucose pyrophosphorylase 1;
DE            Short=UDPGP 1;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase 1;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase 1;
GN   Name=gtaB1; OrderedLocusNames=SSP0059;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 /
OS   DSM 20229).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K.,
RA   Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S.,
RA   Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Catalyzes the formation of UDP-glucose from glucose-1-
CC       phosphate and UTP. This is an intermediate step in the
CC       biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a
CC       glycolipid found in the membrane, which is also used as a membrane
CC       anchor for lipoteichoic acid (LTA) (By similarity).
CC   -!- CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate =
CC       diphosphate + UDP-glucose.
CC   -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family.
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DR   EMBL; AP008934; BAE17204.1; -; Genomic_DNA.
DR   RefSeq; YP_300149.1; -.
DR   GeneID; 3617264; -.
DR   GenomeReviews; AP008934_GR; SSP0059.
DR   KEGG; ssp:SSP0059; -.
DR   NMPDR; fig|342451.4.peg.199; -.
DR   HOGENOM; Q4A122; -.
DR   OMA; Q4A122; FQANLED.
DR   BioCyc; SSAP342451:SSP0059-MON; -.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase...; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   InterPro; IPR005771; GalU_trans_bac.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Nucleotidyltransferase;
KW   Transferase.
FT   CHAIN         1    287       UTP--glucose-1-phosphate
FT                                uridylyltransferase 1.
FT                                /FTId=PRO_0000308313.
SQ   SEQUENCE   287 AA;  32528 MW;  4553CABFC6DAD2F2 CRC64;
     MKIKKAIIPA AGLGTRFLPA TKAMPKEMLP ILDKPTIQYI VEEAVAAGIE DIIIVTGKHK
     RAIEDHFDNQ KELEMILEEK GKSDLLQSVK YSSNLANMFY VRQKEQKGLG HAIWTARQFI
     GNEPFAVLLG DDIVQADTPA IKQLMNQYET TGKSIIGVQQ VNEIETHRYG IVDPEESYNE
     LFSVNKFVEK PEIGTAPSNL AIMGRYVLKP DIFDYLERQE IGRGGEIQLT DAIEHLNSED
     CVYAYNFEGE RYDVGEKIGF VKTTIQFALK DDYMKKEITE FIKSINK
//