Reviewed, UniProtKB/Swiss-Prot Q4A122 (GTAB1_STAS1)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 1
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase 1
      Short name=UDPGP 1
    Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
    Uridine diphosphoglucose pyrophosphorylase 1

Gene names

Name:	gtaB1
Ordered Locus Names:	SSP0059

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	UTP--glucose-1-phosphate uridylyltransferase 1		PRO_0000308313

Sequences

	Sequence		Length	Mass (Da)
	Q4A122-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 4553CABFC6DAD2F2	FASTA	287	32,528
	10 20 30 40 50 60 MKIKKAIIPA AGLGTRFLPA TKAMPKEMLP ILDKPTIQYI VEEAVAAGIE DIIIVTGKHK 70 80 90 100 110 120 RAIEDHFDNQ KELEMILEEK GKSDLLQSVK YSSNLANMFY VRQKEQKGLG HAIWTARQFI 130 140 150 160 170 180 GNEPFAVLLG DDIVQADTPA IKQLMNQYET TGKSIIGVQQ VNEIETHRYG IVDPEESYNE 190 200 210 220 230 240 LFSVNKFVEK PEIGTAPSNL AIMGRYVLKP DIFDYLERQE IGRGGEIQLT DAIEHLNSED 250 260 270 280 CVYAYNFEGE RYDVGEKIGF VKTTIQFALK DDYMKKEITE FIKSINK

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE17204.1.
RefSeq	YP_300149.1.
3D structure databases
SMR	Q4A122. Positions 1-282.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4A122.
Genome annotation databases
GeneID	3617264.
GenomeReviews	Gene locus SSP0059 in contig AP008934_GR.
KEGG	ssp:SSP0059.
NMPDR	fig|342451.4.peg.199.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1210.
HOGENOM	HBG688195.
OMA	EPVEAYH.
PhylomeDB	Q4A122.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP0059-MONOMER.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GTAB1_STAS1

Accession

Primary (citable) accession number: Q4A122

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	September 13, 2005
Last modified:	February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)