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Protein

UTP--glucose-1-phosphate uridylyltransferase 1

Gene

gtaB1

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi: diglucosyl-diacylglycerol biosynthesis

This protein is involved in the pathway diglucosyl-diacylglycerol biosynthesis, which is part of Glycolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway diglucosyl-diacylglycerol biosynthesis and in Glycolipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA00894

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 1 (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
UDP-glucose pyrophosphorylase 1
Short name:
UDPGP 1
Uridine diphosphoglucose pyrophosphorylase 1
Gene namesi
Name:gtaB1
Ordered Locus Names:SSP0059
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006371 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083131 – 287UTP--glucose-1-phosphate uridylyltransferase 1Add BLAST287

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP0059

Structurei

3D structure databases

ProteinModelPortaliQ4A122
SMRiQ4A122
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105C3Y Bacteria
COG1210 LUCA
HOGENOMiHOG000283477
KOiK00963
OMAiYLCFFGM
OrthoDBiPOG091H03RN

Family and domain databases

CDDicd02541 UGPase_prokaryotic, 1 hit
Gene3Di3.90.550.101 hit
InterProiView protein in InterPro
IPR005771 GalU_uridylyltTrfase_bac/arc
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR43197 PTHR43197, 1 hit
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR01099 galU, 1 hit

Sequencei

Sequence statusi: Complete.

Q4A122-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKKAIIPA AGLGTRFLPA TKAMPKEMLP ILDKPTIQYI VEEAVAAGIE
60 70 80 90 100
DIIIVTGKHK RAIEDHFDNQ KELEMILEEK GKSDLLQSVK YSSNLANMFY
110 120 130 140 150
VRQKEQKGLG HAIWTARQFI GNEPFAVLLG DDIVQADTPA IKQLMNQYET
160 170 180 190 200
TGKSIIGVQQ VNEIETHRYG IVDPEESYNE LFSVNKFVEK PEIGTAPSNL
210 220 230 240 250
AIMGRYVLKP DIFDYLERQE IGRGGEIQLT DAIEHLNSED CVYAYNFEGE
260 270 280
RYDVGEKIGF VKTTIQFALK DDYMKKEITE FIKSINK
Length:287
Mass (Da):32,528
Last modified:September 13, 2005 - v1
Checksum:i4553CABFC6DAD2F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA Translation: BAE17204.1

Genome annotation databases

EnsemblBacteriaiBAE17204; BAE17204; SSP0059
KEGGissp:SSP0059

Similar proteinsi

Entry informationi

Entry nameiGTAB1_STAS1
AccessioniPrimary (citable) accession number: Q4A122
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome