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Q4A0Q1

- BETA_STAS1

UniProt

Q4A0Q1 - BETA_STAS1

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, SSP0196
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei472 – 4721 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-198-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:SSP0196
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_0000205604Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP0196.

Structurei

3D structure databases

ProteinModelPortaliQ4A0Q1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiASTKDIC.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4A0Q1-1 [UniParc]FASTAAdd to Basket

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MKQSYDYIII GGGSAGSVLG SRISEDVSNN VLVLEAGRSD YPWDLLIQMP    50
AALMYPAGNK LYDWIYETTP EPHMDGRKVG HARGKVLGGS SSINGMIYQR 100
GNPMDYEKWA KPEGMDSWDY AHCLPYFKRL EKTFGATKDD QFRGHHGPIK 150
LRRGPADNPL FQAFFDAGVE AGYNKTPDVN GFRQEGFGPF DSQVHNGRRV 200
SASRAYLHPA MKRKNLEVQT RAFVTKLNFE GNKVTGVTFK KNGREHTVNA 250
KEVILSGGAI NSPQLLQLSG IGDSEHLRSL GIEPRIHLPG VGENFEDHLE 300
VYVQHACKEP VSMQPSLNKL KMPFIGLQWI FGRKGAAASN HFEGGGFVRS 350
NEDVDYPNLM FHFLPIAVRY DGTKAPAAHG YQVHVGPMYS NSRGHLKIKS 400
KDPFVKPDFV FNYLSTEEDK REWVEAIKVA RNILGQKALD PYNGGEISPG 450
PEVQTDEEII EWVKRDGETA LHPSCSCRMG PASDEMSVVD PETFKVHGME 500
NLRVVDASVM PRTTNGNIHS PVLMMAEKAA DIIRGKKPLD PEYIDFYRHG 550
VHDKDAGTIK 560
Length:560
Mass (Da):62,402
Last modified:September 13, 2005 - v1
Checksum:i1CC3118F7D34A097
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE17341.1.
RefSeqiWP_002482148.1. NC_007350.1.
YP_300286.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE17341; BAE17341; SSP0196.
GeneIDi3615110.
KEGGissp:SSP0196.
PATRICi19621883. VBIStaSap90642_0202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE17341.1 .
RefSeqi WP_002482148.1. NC_007350.1.
YP_300286.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q4A0Q1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP0196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE17341 ; BAE17341 ; SSP0196 .
GeneIDi 3615110.
KEGGi ssp:SSP0196.
PATRICi 19621883. VBIStaSap90642_0202.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi ASTKDIC.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SSAP342451:GKFA-198-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiBETA_STAS1
AccessioniPrimary (citable) accession number: Q4A0Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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