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Q4A0Q1 (BETA_STAS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:SSP0196
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000205604

Regions

Nucleotide binding6 – 3530FAD By similarity

Sites

Active site4721 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4A0Q1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 1CC3118F7D34A097

FASTA56062,402
        10         20         30         40         50         60 
MKQSYDYIII GGGSAGSVLG SRISEDVSNN VLVLEAGRSD YPWDLLIQMP AALMYPAGNK 

        70         80         90        100        110        120 
LYDWIYETTP EPHMDGRKVG HARGKVLGGS SSINGMIYQR GNPMDYEKWA KPEGMDSWDY 

       130        140        150        160        170        180 
AHCLPYFKRL EKTFGATKDD QFRGHHGPIK LRRGPADNPL FQAFFDAGVE AGYNKTPDVN 

       190        200        210        220        230        240 
GFRQEGFGPF DSQVHNGRRV SASRAYLHPA MKRKNLEVQT RAFVTKLNFE GNKVTGVTFK 

       250        260        270        280        290        300 
KNGREHTVNA KEVILSGGAI NSPQLLQLSG IGDSEHLRSL GIEPRIHLPG VGENFEDHLE 

       310        320        330        340        350        360 
VYVQHACKEP VSMQPSLNKL KMPFIGLQWI FGRKGAAASN HFEGGGFVRS NEDVDYPNLM 

       370        380        390        400        410        420 
FHFLPIAVRY DGTKAPAAHG YQVHVGPMYS NSRGHLKIKS KDPFVKPDFV FNYLSTEEDK 

       430        440        450        460        470        480 
REWVEAIKVA RNILGQKALD PYNGGEISPG PEVQTDEEII EWVKRDGETA LHPSCSCRMG 

       490        500        510        520        530        540 
PASDEMSVVD PETFKVHGME NLRVVDASVM PRTTNGNIHS PVLMMAEKAA DIIRGKKPLD 

       550        560 
PEYIDFYRHG VHDKDAGTIK 

« Hide

References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008934 Genomic DNA. Translation: BAE17341.1.
RefSeqYP_300286.1. NC_007350.1.

3D structure databases

ProteinModelPortalQ4A0Q1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342451.SSP0196.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE17341; BAE17341; SSP0196.
GeneID3615110.
KEGGssp:SSP0196.
PATRIC19621883. VBIStaSap90642_0202.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAASTKDIC.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycSSAP342451:GKFA-198-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_STAS1
AccessionPrimary (citable) accession number: Q4A0Q1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways