Q4A0N2 (OAT1_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine aminotransferase 1
Short name=OAT 1
EC=2.6.1.13

Alternative name(s):
Ornithine--oxo-acid aminotransferase 1

Gene names

Name:	rocD1
Ordered Locus Names:	SSP0220

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of ornithine to glutamate semialdehyde By similarity. HAMAP MF_01689
Catalytic activity	L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. HAMAP MF_01689
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01689
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1. HAMAP MF_01689
Subcellular location	Cytoplasm By similarity HAMAP MF_01689.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: InterPro proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ornithine-oxo-acid transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Ornithine aminotransferase 1 HAMAP MF_01689		PRO_0000112796
Amino acid modifications
	Modified residue	252	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4A0N2 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: D4DE3FBB2D343364	FASTA	394	43,538
	10 20 30 40 50 60 MLDLYEHTDK YSSKNYSPLK LALAKGRGAK VWDIEDNCYI DCISGFSVVN QGHCHPKIIK 70 80 90 100 110 120 ALQEQSQRIT MVSRALYSDN LGKWEEKICK LANKENVLPM NTGTEAVETA IKMARKWGAD 130 140 150 160 170 180 IKNIDESSSE IIAMNGNFHG RTLGSLSLSS QDSYKKGFGP LLNNIHYADF GDIEQLKKLI 190 200 210 220 230 240 NNQTTAIILE PIQGEGGVNI PPTHFIQEVR QLCNEYNVLL IADEIQVGLG RTGKMFAMEW 250 260 270 280 290 300 ENTEPDIYLL GKSLGGGLYP ISAVLANQDV MSVLTPGTHG STFGGNPLAC AVSMAALDVL 310 320 330 340 350 360 NEEHLVQNAL DLGDRLLKHL QQIESELIVE VRGRGLFIGI ELNVAAQDYC EQMINKGVLC 370 380 390 KETQGNIIRI APPLVIDKDE IDEVIRVITE VLEK

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE17365.1.
RefSeq	YP_300310.1. NC_007350.1.
3D structure databases
ProteinModelPortal	Q4A0N2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4A0N2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000047176; EBSTAP00000045545; EBSTAG00000047173.
GeneID	3617138.
GenomeReviews	Gene locus SSP0220 in contig AP008934_GR.
KEGG	ssp:SSP0220.
NMPDR	fig|342451.4.peg.571.
PATRIC	19621929. VBIStaSap90642_0225.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4992.
GeneTree	EBGT00050000024123.
HOGENOM	HBG725944.
PhylomeDB	Q4A0N2.
ProtClustDB	CLSK884462.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP0220-MONOMER.
Family and domain databases
HAMAP	MF_01689. Ornith_aminotrans_3. [Tree]
InterPro	IPR004636. AcOrn/SuccinylOrn_aminoTrfase. IPR005814. Aminotrans_3. IPR010164. Orn_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K00819.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF18. Orn_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00707. ArgD. 1 hit. TIGR01885. Orn_aminotrans. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OAT1_STAS1

Accession

Primary (citable) accession number: Q4A0N2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program