Q4A094 (NANE_STAS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative N-acetylmannosamine-6-phosphate 2-epimerase
EC=5.1.3.9

Alternative name(s):
ManNAc-6-P epimerase

Gene names

Name:	nanE
Ordered Locus Names:	SSP0372

Organism

Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]

Taxonomic identifier

342451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) Potential. HAMAP MF_01235
Catalytic activity	N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01235
Pathway	Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5. HAMAP MF_01235
Sequence similarities	Belongs to the nanE family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylmannosamine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	N-acylglucosamine-6-phosphate 2-epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Putative N-acetylmannosamine-6-phosphate 2-epimerase HAMAP MF_01235		PRO_0000301488

Sequences

	Sequence		Length	Mass (Da)
	Q4A094 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 1C2906F73EA8FC5F	FASTA	222	24,438
	10 20 30 40 50 60 MLPQGLIVSC QALPDEPLHS SFIMSKMALA AYEGGAVGIR ANSKADIIEI KKEVDLPVIG 70 80 90 100 110 120 IVKRDYAHSD VFITATSKEI DELIESNCEV IALDATKQTR PKESLSELVS YIRNKAPNVE 130 140 150 160 170 180 IMADISTLEE AKNADELGFD YVGTTLRGYT SYTKGHILYE NNYQFLKDVL AHVNAKVIAE 190 200 210 220 GNVITPEMFK DVTDLGVHCT VVGGAITRPK EITKRFINAF DK

References

[1]

"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection." Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed: 16135568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008934 Genomic DNA. Translation: BAE17517.1.
RefSeq	YP_300462.1. NC_007350.1.
3D structure databases
HSSP	HSSP built from PDB template 1YXY based on UniProtKB P65522.
ProteinModelPortal	Q4A094.
SMR	Q4A094. Positions 1-221.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4A094.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000047758; EBSTAP00000046127; EBSTAG00000047755.
GeneID	3617192.
GenomeReviews	Gene locus SSP0372 in contig AP008934_GR.
KEGG	ssp:SSP0372.
NMPDR	fig|342451.4.peg.230.
PATRIC	19622233. VBIStaSap90642_0377.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3010.
GeneTree	EBGT00050000025172.
HOGENOM	HBG296941.
OMA	CQALEDE.
PhylomeDB	Q4A094.
ProtClustDB	PRK01130.
Enzyme and pathway databases
BioCyc	SSAP342451:SSP0372-MONOMER.
Family and domain databases
HAMAP	MF_01235. ManNAc6P_epimer. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR007260. NanE. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01788.
Pfam	PF04131. NanE. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NANE_STAS1

Accession

Primary (citable) accession number: Q4A094

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program