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Q4A044

- HISX_STAS1

UniProt

Q4A044 - HISX_STAS1

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Protein

Histidinol dehydrogenase

Gene
hisD, SSP0429
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161NAD By similarity
Binding sitei177 – 1771NAD By similarity
Binding sitei200 – 2001NAD By similarity
Binding sitei223 – 2231Substrate By similarity
Metal bindingi245 – 2451Zinc By similarity
Binding sitei245 – 2451Substrate By similarity
Metal bindingi248 – 2481Zinc By similarity
Binding sitei248 – 2481Substrate By similarity
Active sitei313 – 3131Proton acceptor By similarity
Active sitei314 – 3141Proton acceptor By similarity
Binding sitei314 – 3141Substrate By similarity
Metal bindingi347 – 3471Zinc By similarity
Binding sitei347 – 3471Substrate By similarity
Binding sitei401 – 4011Substrate By similarity
Metal bindingi406 – 4061Zinc By similarity
Binding sitei406 – 4061Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-431-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:SSP0429
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Histidinol dehydrogenaseUniRule annotationPRO_0000135857Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP0429.

Structurei

3D structure databases

ProteinModelPortaliQ4A044.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiDEMAMPI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4A044-1 [UniParc]FASTAAdd to Basket

« Hide

MIIDKTLFLK KYLNQSSLNE DLYPIVKDIC ENVRLHGDDA LRNYNQQFDQ    50
VETCNLEVAY QTLENAYNRL DSDLREALQQ SHARIQSYQE SIKWTKQQGT 100
SDCYELYHPL ERVGVYVPGG KASYPSTVLM TVTLAKVAGV KNISVVTPPQ 150
LNGIPDIVLA ACYIAGVDNV YQVGGAQSIA ALAYGTETLP KVDKIVGPGN 200
QFVAYAKKYL FGQVGIDQIA GPSEIALIID DSADLDAIAY DVFAQAEHDE 250
LARTFVISED EALLKQLEQK IQHILPQIER QSIVQASLND NHFLIHVNNF 300
SEACDLMNQI APEHASIQTV SPHDYLNHVR YVGALFLGYY SPEVIGDYVA 350
GPSHVLPTNQ TARFTNGLSV NDFLTRHSVI DLSKDTFDTV ELTARKLAHV 400
EQLYNHEQSI EIRTSKEFND DKN 423
Length:423
Mass (Da):47,268
Last modified:September 13, 2005 - v1
Checksum:iAD6BEF5C7FA5E229
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE17574.1.
RefSeqiWP_011302397.1. NC_007350.1.
YP_300519.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE17574; BAE17574; SSP0429.
GeneIDi3616177.
KEGGissp:SSP0429.
PATRICi19622347. VBIStaSap90642_0434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008934 Genomic DNA. Translation: BAE17574.1 .
RefSeqi WP_011302397.1. NC_007350.1.
YP_300519.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q4A044.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP0429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE17574 ; BAE17574 ; SSP0429 .
GeneIDi 3616177.
KEGGi ssp:SSP0429.
PATRICi 19622347. VBIStaSap90642_0434.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi DEMAMPI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SSAP342451:GKFA-431-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiHISX_STAS1
AccessioniPrimary (citable) accession number: Q4A044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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