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Q4A044

- HISX_STAS1

UniProt

Q4A044 - HISX_STAS1

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161NADUniRule annotation
    Binding sitei177 – 1771NADUniRule annotation
    Binding sitei200 – 2001NADUniRule annotation
    Binding sitei223 – 2231SubstrateUniRule annotation
    Metal bindingi245 – 2451ZincUniRule annotation
    Binding sitei245 – 2451SubstrateUniRule annotation
    Metal bindingi248 – 2481ZincUniRule annotation
    Binding sitei248 – 2481SubstrateUniRule annotation
    Active sitei313 – 3131Proton acceptorUniRule annotation
    Active sitei314 – 3141Proton acceptorUniRule annotation
    Binding sitei314 – 3141SubstrateUniRule annotation
    Metal bindingi347 – 3471ZincUniRule annotation
    Binding sitei347 – 3471SubstrateUniRule annotation
    Binding sitei401 – 4011SubstrateUniRule annotation
    Metal bindingi406 – 4061ZincUniRule annotation
    Binding sitei406 – 4061SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciSSAP342451:GKFA-431-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:SSP0429
    OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
    Taxonomic identifieri342451 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006371: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Histidinol dehydrogenasePRO_0000135857Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi342451.SSP0429.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4A044.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiDEMAMPI.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4A044-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIDKTLFLK KYLNQSSLNE DLYPIVKDIC ENVRLHGDDA LRNYNQQFDQ    50
    VETCNLEVAY QTLENAYNRL DSDLREALQQ SHARIQSYQE SIKWTKQQGT 100
    SDCYELYHPL ERVGVYVPGG KASYPSTVLM TVTLAKVAGV KNISVVTPPQ 150
    LNGIPDIVLA ACYIAGVDNV YQVGGAQSIA ALAYGTETLP KVDKIVGPGN 200
    QFVAYAKKYL FGQVGIDQIA GPSEIALIID DSADLDAIAY DVFAQAEHDE 250
    LARTFVISED EALLKQLEQK IQHILPQIER QSIVQASLND NHFLIHVNNF 300
    SEACDLMNQI APEHASIQTV SPHDYLNHVR YVGALFLGYY SPEVIGDYVA 350
    GPSHVLPTNQ TARFTNGLSV NDFLTRHSVI DLSKDTFDTV ELTARKLAHV 400
    EQLYNHEQSI EIRTSKEFND DKN 423
    Length:423
    Mass (Da):47,268
    Last modified:September 13, 2005 - v1
    Checksum:iAD6BEF5C7FA5E229
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE17574.1.
    RefSeqiWP_011302397.1. NC_007350.1.
    YP_300519.1. NC_007350.1.

    Genome annotation databases

    EnsemblBacteriaiBAE17574; BAE17574; SSP0429.
    GeneIDi3616177.
    KEGGissp:SSP0429.
    PATRICi19622347. VBIStaSap90642_0434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008934 Genomic DNA. Translation: BAE17574.1 .
    RefSeqi WP_011302397.1. NC_007350.1.
    YP_300519.1. NC_007350.1.

    3D structure databases

    ProteinModelPortali Q4A044.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 342451.SSP0429.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE17574 ; BAE17574 ; SSP0429 .
    GeneIDi 3616177.
    KEGGi ssp:SSP0429.
    PATRICi 19622347. VBIStaSap90642_0434.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi DEMAMPI.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci SSAP342451:GKFA-431-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
      Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
      Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15305 / DSM 20229.

    Entry informationi

    Entry nameiHISX_STAS1
    AccessioniPrimary (citable) accession number: Q4A044
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3