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Q4A044 (HISX_STAS1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:SSP0429
OrganismStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) [Complete proteome] [HAMAP]
Taxonomic identifier342451 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135857

Sites

Active site3131Proton acceptor By similarity
Active site3141Proton acceptor By similarity
Metal binding2451Zinc By similarity
Metal binding2481Zinc By similarity
Metal binding3471Zinc By similarity
Metal binding4061Zinc By similarity
Binding site1161NAD By similarity
Binding site1771NAD By similarity
Binding site2001NAD By similarity
Binding site2231Substrate By similarity
Binding site2451Substrate By similarity
Binding site2481Substrate By similarity
Binding site3141Substrate By similarity
Binding site3471Substrate By similarity
Binding site4011Substrate By similarity
Binding site4061Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4A044 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: AD6BEF5C7FA5E229

FASTA42347,268
        10         20         30         40         50         60 
MIIDKTLFLK KYLNQSSLNE DLYPIVKDIC ENVRLHGDDA LRNYNQQFDQ VETCNLEVAY 

        70         80         90        100        110        120 
QTLENAYNRL DSDLREALQQ SHARIQSYQE SIKWTKQQGT SDCYELYHPL ERVGVYVPGG 

       130        140        150        160        170        180 
KASYPSTVLM TVTLAKVAGV KNISVVTPPQ LNGIPDIVLA ACYIAGVDNV YQVGGAQSIA 

       190        200        210        220        230        240 
ALAYGTETLP KVDKIVGPGN QFVAYAKKYL FGQVGIDQIA GPSEIALIID DSADLDAIAY 

       250        260        270        280        290        300 
DVFAQAEHDE LARTFVISED EALLKQLEQK IQHILPQIER QSIVQASLND NHFLIHVNNF 

       310        320        330        340        350        360 
SEACDLMNQI APEHASIQTV SPHDYLNHVR YVGALFLGYY SPEVIGDYVA GPSHVLPTNQ 

       370        380        390        400        410        420 
TARFTNGLSV NDFLTRHSVI DLSKDTFDTV ELTARKLAHV EQLYNHEQSI EIRTSKEFND 


DKN 

« Hide

References

[1]"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15305 / DSM 20229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008934 Genomic DNA. Translation: BAE17574.1.
RefSeqYP_300519.1. NC_007350.1.

3D structure databases

ProteinModelPortalQ4A044.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING342451.SSP0429.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE17574; BAE17574; SSP0429.
GeneID3616177.
KEGGssp:SSP0429.
PATRIC19622347. VBIStaSap90642_0434.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
OrthoDBEOG6CVVCR.
ProtClustDBPRK13770.

Enzyme and pathway databases

BioCycSSAP342451:GKFA-431-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_STAS1
AccessionPrimary (citable) accession number: Q4A044
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways