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Q4A044

- HISX_STAS1

UniProt

Q4A044 - HISX_STAS1

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161NADUniRule annotation
Binding sitei177 – 1771NADUniRule annotation
Binding sitei200 – 2001NADUniRule annotation
Binding sitei223 – 2231SubstrateUniRule annotation
Metal bindingi245 – 2451ZincUniRule annotation
Binding sitei245 – 2451SubstrateUniRule annotation
Metal bindingi248 – 2481ZincUniRule annotation
Binding sitei248 – 2481SubstrateUniRule annotation
Active sitei313 – 3131Proton acceptorUniRule annotation
Active sitei314 – 3141Proton acceptorUniRule annotation
Binding sitei314 – 3141SubstrateUniRule annotation
Metal bindingi347 – 3471ZincUniRule annotation
Binding sitei347 – 3471SubstrateUniRule annotation
Binding sitei401 – 4011SubstrateUniRule annotation
Metal bindingi406 – 4061ZincUniRule annotation
Binding sitei406 – 4061SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSSAP342451:GKFA-431-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:SSP0429
OrganismiStaphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Taxonomic identifieri342451 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006371: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Histidinol dehydrogenasePRO_0000135857Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi342451.SSP0429.

Structurei

3D structure databases

ProteinModelPortaliQ4A044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiDEMAMPI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4A044-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIDKTLFLK KYLNQSSLNE DLYPIVKDIC ENVRLHGDDA LRNYNQQFDQ
60 70 80 90 100
VETCNLEVAY QTLENAYNRL DSDLREALQQ SHARIQSYQE SIKWTKQQGT
110 120 130 140 150
SDCYELYHPL ERVGVYVPGG KASYPSTVLM TVTLAKVAGV KNISVVTPPQ
160 170 180 190 200
LNGIPDIVLA ACYIAGVDNV YQVGGAQSIA ALAYGTETLP KVDKIVGPGN
210 220 230 240 250
QFVAYAKKYL FGQVGIDQIA GPSEIALIID DSADLDAIAY DVFAQAEHDE
260 270 280 290 300
LARTFVISED EALLKQLEQK IQHILPQIER QSIVQASLND NHFLIHVNNF
310 320 330 340 350
SEACDLMNQI APEHASIQTV SPHDYLNHVR YVGALFLGYY SPEVIGDYVA
360 370 380 390 400
GPSHVLPTNQ TARFTNGLSV NDFLTRHSVI DLSKDTFDTV ELTARKLAHV
410 420
EQLYNHEQSI EIRTSKEFND DKN
Length:423
Mass (Da):47,268
Last modified:September 13, 2005 - v1
Checksum:iAD6BEF5C7FA5E229
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE17574.1.
RefSeqiWP_011302397.1. NC_007350.1.
YP_300519.1. NC_007350.1.

Genome annotation databases

EnsemblBacteriaiBAE17574; BAE17574; SSP0429.
GeneIDi3616177.
KEGGissp:SSP0429.
PATRICi19622347. VBIStaSap90642_0434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008934 Genomic DNA. Translation: BAE17574.1 .
RefSeqi WP_011302397.1. NC_007350.1.
YP_300519.1. NC_007350.1.

3D structure databases

ProteinModelPortali Q4A044.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 342451.SSP0429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE17574 ; BAE17574 ; SSP0429 .
GeneIDi 3616177.
KEGGi ssp:SSP0429.
PATRICi 19622347. VBIStaSap90642_0434.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi DEMAMPI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SSAP342451:GKFA-431-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15305 / DSM 20229.

Entry informationi

Entry nameiHISX_STAS1
AccessioniPrimary (citable) accession number: Q4A044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3